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Lack of Association of Common Polymorphisms in MUC1 Gene with H. pylori Infection and Non-cardia Gastric Cancer Risk in a Chinese Population

  • Zhang, Bin (School of Basic Medicine, Baotou Medical College) ;
  • Hao, Guang-Yu (School of Basic Medicine, Baotou Medical College) ;
  • Gao, Fang (School of Basic Medicine, Baotou Medical College) ;
  • Zhang, Jian-Zu (The First Affiliated Hospital of Baotou Medical College) ;
  • Zhou, Cheng-Jiang (School of Basic Medicine, Baotou Medical College) ;
  • Zhou, Li-She (School of Basic Medicine, Baotou Medical College) ;
  • Wang, Ying (School of Basic Medicine, Baotou Medical College) ;
  • Jia, Yan-Bin (School of Basic Medicine, Baotou Medical College)
  • Published : 2013.12.31

Abstract

Several lines of evidence support the notion that MUC1 is often aberrantly expressed in gastric cancer, and it is a ligand for Helicobacter pylori. Genetic variation in MUC1 gene may confer susceptibility to H. pylori infection and gastric cancer. We assessed the association of common polymorphisms in MUC1 gene with H. pylori infection and non-cardia gastric cancer using an LD-based tag SNP approach in north-western Chinese Han population. A total of four SNPs were successfully genotyped among 288 patients with non-cardia gastric cancer and 281 age- and sex-matched controls. None of the tested SNPs was associated with H. pylori infection. SNP rs9426886 was associated with a decreased risk of non-cardia gastric cancer, but lost significance after adjustment for multiple testing. Overall, our data indicated that common genetic variations in MUC1 gene might not make a major contribution to the risk of H. pylori infection and non-cardia gastric cancer in our studied population.

References

  1. Correa P (2004). The biological model of gastric carcinogenesis. IARC Sci Publ, 157, 301-10.
  2. Costa NR, Mendes N, Marcos NT, et al (2008). Relevance of MUC1 mucin variable number of tandem repeats polymorphism in H pylori adhesion to gastric epithelial cells. World J Gastroenterol, 14, 1411-4. https://doi.org/10.3748/wjg.14.1411
  3. Farinati F, Valiante F, Germana B, et al (1993). Prevalence of Helicobacter pylori infection in patients with precancerous changes and gastric cancer. Eur J Cancer Prev, 2, 321-6. https://doi.org/10.1097/00008469-199307000-00006
  4. Frank B, Weck MN, Muller H, et al (2012). Polymorphisms in MUC1, MUC2, MUC5B and MUC6 genes are not associated with the risk of chronic atrophic gastritis. Eur J Cancer, 48, 114-20.
  5. He C, Tu H, Sun L, et al (2013). Helicobacter pylori-related host gene polymorphisms associated with susceptibility of gastric carcinogenesis: a two-stage case-control study in Chinese. Carcinogenesis, 34, 1450-7. https://doi.org/10.1093/carcin/bgt079
  6. Jia Y, Persson C, Hou L, et al (2010). A comprehensive analysis of common genetic variation in MUC1, MUC5AC, MUC6 genes and risk of stomach cancer. Cancer Causes Control, 21, 313-21. https://doi.org/10.1007/s10552-009-9463-3
  7. Jiang Z, Li C, Xu Y, Cai S (2010). A meta-analysis on XRCC1 and XRCC3 polymorphisms and colorectal cancer risk. Int J Colorectal Dis, 25, 169-80. https://doi.org/10.1007/s00384-009-0817-9
  8. Karnes WE Jr, Samloff IM, Siurala M, et al (1991). Positive serum antibody and negative tissue staining for Helicobacter pylori in subjects with atrophic body gastritis. Gastroenterology, 101, 167-74. https://doi.org/10.1016/0016-5085(91)90474-Y
  9. Kim MA, Lee HS, Yang HK, Kim WH (2005). Clinicopathologic and protein expression differences between cardia carcinoma and noncardia carcinoma of the stomach. Cancer, 103, 1439-46. https://doi.org/10.1002/cncr.20966
  10. Abnet CC, Freedman ND, Hu N, et al (2010). A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma. Nat Genet, 42, 764-7. https://doi.org/10.1038/ng.649
  11. Brenner H, Rothenbacher D, Arndt V (2009). Epidemiology of stomach cancer. Methods Mol Biol, 472, 467-77. https://doi.org/10.1007/978-1-60327-492-0_23
  12. Linden SK, Wickstrom C, Lindell G, Gilshenan K, Carlstedt I (2008). Four modes of adhesion are used during Helicobacter pylori binding to human mucins in the oral and gastric niches. Helicobacter, 13, 81-93. https://doi.org/10.1111/j.1523-5378.2008.00587.x
  13. Ng W, Loh AX, Teixeira AS, Pereira SP, Swallow DM (2008). Genetic regulation of MUC1 alternative splicing in human tissues. Br J Cancer, 99, 978-85. https://doi.org/10.1038/sj.bjc.6604617
  14. Peek RM Jr, Blaser MJ (2002). Helicobacter pylori and gastrointestinal tract adenocarcinomas. Nat Rev Cancer, 2, 28-37. https://doi.org/10.1038/nrc703
  15. Vinall LE, King M, Novelli M, et al (2002). Altered expression and allelic association of the hypervariable membrane mucin MUC1 in Helicobacter pylori gastritis. Gastroenterology, 123, 41-9. https://doi.org/10.1053/gast.2002.34157
  16. Westfall P, Young S (1993). Resampling-based multiple testing: examples and methods for p-value adjustment. Wiley publisher, USA.
  17. Xu Q, Yuan Y, Sun LP, et al (2009). Risk of gastric cancer is associated with the MUC1 568 A/G polymorphism. Int J Oncol, 35, 1313-20.
  18. Zhang H, Jin G, Li H, et al (2011). Genetic variants at 1q22 and 10q23 reproducibly associated with gastric cancer susceptibility in a Chinese population. Carcinogenesis, 32, 848-52. https://doi.org/10.1093/carcin/bgr051

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