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MCPH1 Protein Expression in Normal and Neoplastic Lung Tissues

  • Zhang, Ji (Molecular Medicine & Cancer Research Center) ;
  • Wu, Xiao-Bin (Molecular Medicine & Cancer Research Center) ;
  • Fan, Jian-Jun (Molecular Medicine & Cancer Research Center) ;
  • Mai, Li (Molecular Medicine & Cancer Research Center) ;
  • Cai, Wei (Department of Pathology of the First Affiliated Hospital of Chongqing Medical University) ;
  • Li, Dan (Department of Pathology of the First Affiliated Hospital of Chongqing Medical University) ;
  • Yuan, Cheng-Fu (Molecular Medicine & Cancer Research Center) ;
  • Bu, You-Quan (Department of Biochemistry & Molecular Biology, College of Basic Medicine, Chongqing Medical University) ;
  • Song, Fang-Zhou (Department of Biochemistry & Molecular Biology, College of Basic Medicine, Chongqing Medical University)
  • Published : 2013.12.31

Abstract

Lung cancer is the most common cause of cancer-related death in the world. The main types are small-cell lung carcinoma (SCLC) and non-small-cell lung carcinoma (NSCLC), the latter including squamous cell carcinoma (SCC), adenocarcinoma and large cell carcinoma. NSCLCs account for about 80% of all lung cancer cases. Microcephalin (MCPH1), also called BRIT1 (BRCT-repeat inhibitor of hTERT expression), plays an important role in the maintenance of genomic stability. Recently, several studies have provided evidence that the expression of MCPH1 gene is decreased in several different types of human cancers. We evaluated the expression of protein MCPH1 in 188 lung cancer and 20 normal lung tissues by immunohistochemistry. Positive MCPH1 staining was found in all normal lung samples and only some cancerous tissues. MCPH1-positive cells were significantly lower in lung carcinoma compared with normal tissues. Furthermore, we firstly found that MCPH1 expression in lung adenocarcinoma is higher than its expression in squamous cell carcinoma. Change in MCPH1 protein expression may be associated with lung tumorigenesis and may be a useful biomarker for identification of pathological types of lung cancer.

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