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Clinico-pathology of Lung Cancer in a Regional Cancer Center in Northeastern India

  • Published : 2013.12.31

Abstract

Background: Globally, there have been important changes in trends amongst gender, histology and smoking patterns of lung cancer cases. Materials and Methods: This retrospective study was conducted on 466 patients with lung cancer who were registered in Regional Cancer Center, Regional Institute of Medical Sciences, Manipur from January 2008 to December 2012. Results: Most were more than 60 years of age (67.8%) with a male: female ratio of 1.09:1. Some 78.8% of patients were chronic smokers with male smoker to female smoker ratio of 1.43:1. Consumption of alcohol was found in 29.4%, both smoking and alcohol in 27.5%, betel nut chewing in 37.9% and tobacco chewing in 25.3%. A history of tuberculosis was present in 16.3% of patients. The most frequent symptom was coughing (36.6%) and most common radiological presentation was a mass lesion (70%). Most of the patients had primary lung cancer in the right lung (60.3%). The most common histological subtype was squamous cell carcinoma (49.1%), also in the 40-60 year age group (45.9%), more than 60 year age group (51.6%), males (58.1%) and females (41.8%). As many as 91.9% of squamous cell carcinoma patients had a history of smoking. About 32.5% of patients had distant metastasis at presentation with brain (23.8%) and positive malignant cells in pleural effusions (23.1%) as common sites. The majority of patients were in stage III (34.4%), stage IV (32.5%) and stage II (30.2%). Conclusions: Our analysis suggests that the gender gap has been narrowed such that about half of the patients diagnosed with lung cancer are women in this part of India. This alarming rise in female incidence is mainly attributed to an increased smoking pattern. Squamous cell carcinoma still remains the commonest histological subtype. Most of the patients were elderly aged and presented at locally or distantly advanced stages.

References

  1. Ahrendt SA, Chow JT, Yang SC, et al (2000). Alcohol consumption and cigarette smoking increase the frequency of p53 mutations in NSCLC. Cancer Res, 60, 3155.
  2. Bal S (2001). Screening for lung cancer. Hospital Today, 6, 609-11.
  3. Becket WS (1993). Epidemiology and etiology of lung cancer. Clin Chest Med, 14, 1-15.
  4. Behera D, Balamugesh T (2004). Lung cancer in India. Indian J Chest Dis Allied Sci, 46, 269-81.
  5. Bhaskarapillai B, Kumar SS, Balasubramanian S (2012). Lung cancer in malabar cancer center in Kerala--a descriptive analysis. Asian Pac J Cancer Prev, 14, 4639-43. https://doi.org/10.7314/APJCP.2012.13.9.4639
  6. Bofefetta P, Aagnes B, Weiderpass E, et al (2005). Smokeless tobacco use and risk of cancer of pancreas and other organs. Int J Cancer, 114, 992-5. https://doi.org/10.1002/ijc.20811
  7. Boffetta P, Hencht S, Gray N, et al (2008). Smokeless tobacco and cancer. Lancet Oncol, 9, 667-75. https://doi.org/10.1016/S1470-2045(08)70173-6
  8. Boyle P (1993). The hazards of passive and active smoking. N Engl J Med, 328, 1708-9. https://doi.org/10.1056/NEJM199306103282311
  9. Charles SW, Templeton PH (1993). Radiologic manifestation of bronchogenic cancer. Clin Chest Med, 14, 55-67.
  10. De Torres JP, Marin JM, Casanova C, et al (2011). Lung cancer in patients with chronic obstructive pulmonary disease - incidence and predicting factors. Am J Respir Crit Care Med, 184, 913-9. https://doi.org/10.1164/rccm.201103-0430OC
  11. Elisa VB, Freudenheim JL, Vena JE (2001). Alcohol consumption and lung cancer- a review of the epidemiologic evidence. Cancer Epidemiol Biomarkers Prev, 10, 813.
  12. Eva P, Morten G, Becker U, et al (1999). Alcohol intake and the risk of lung cancer: influence of type of alcoholic beverage. Am J Epidemiol, 149, 463-70. https://doi.org/10.1093/oxfordjournals.aje.a009834
  13. Ganesh B, Sushama S, Monika S, et al (2011). A case-control study of risk factors for lung cancer in Mumbai, India. Asian Pac J Cancer Prev, 12, 357-62.
  14. Govindan R, Page N, Morgensztern D, et al (2006). Changing epidemiology of small-cell lung cancer in the United States over the last 30 years: analysis of the surveillance, epidemiologic, and end results database. J Clin Oncol, 24, 4539-44. https://doi.org/10.1200/JCO.2005.04.4859
  15. Grivaux M, Zureik M, Marsal L, et al (2011). Five-year survival for lung cancer patients managed in general hospitals. Rev Mal Respir, 28, 31-8. https://doi.org/10.1016/j.rmr.2008.07.001
  16. Gupta RC, Purohit SD, Sharma MP, et al (1998). Primary bronchogenic carcinoma: clinical profile of 279 cases from mid-west Rajasthan. Indian J Chest Dis Allied Sci, 40, 109-16.
  17. Jagadish R, Girish S, Dushyant G, et al (2009). Clinicopathological profile of lung cancer in Uttarakhand. Lung India, 26, 74-6. https://doi.org/10.4103/0970-2113.53229
  18. Johnson BE (1993). Management of small cell lung cancer. Clin Chest Med, 14, 173-87.
  19. Kapoor R, Goswami KC, Kapoor B (1993). Pattern of cancer in Jammu region (hospital based study 1978-87). Indian J Cancer, 30, 67-71.
  20. Khan NA, Afroz F, Lone MM, et al (2006). Profile of lung cancer in Kashmir, India- A five year study. Indian J Chest Dis Allied Sci, 48, 187-90.
  21. Komaki R, Cox JD, Whitson W (1981). Risk of brain metastasis from small cell carcinoma of the lung related to length of survival and prophylactic irradiation. Cancer Treat Rep, 65, 811.
  22. Leroy Hyde, Charles Hyde (1974). Clinical manifestations of lung cancer. Chest, 65, 229-305. https://doi.org/10.1378/chest.65.2.229
  23. Leslie E. Q, Tummala S, Brisson LJ, et al (1996). Distribution of distant metastases from newly diagnosed Non-small cell cancer. Ann Thorac Surg, 62, 246-50. https://doi.org/10.1016/0003-4975(96)00220-2
  24. Liang HY, Li XL, Yu XS, et al (2009). Facts and fiction of the relationship between pre-existing tuberculosis and lung cancer risk: a systematic review, Int J Cancer, 125, 2936-44. https://doi.org/10.1002/ijc.24636
  25. Longo DL (2012). Approach to the patient with cancer, Harrisons principles of internal medicine. McGraw Hill companies, 18, 646.
  26. Malik PS, Sharma MC, Mohanti BK, et al (2013). Clinicopathological profile of lung cancer at AIIMS: a changing paradigm in India. Asian Pac J Cancer Prev, 14, 489-94. https://doi.org/10.7314/APJCP.2013.14.1.489
  27. Mghfoor I, Perry MC (2005). Lung cancer. Ann Saudi Med, 25, 1-12.
  28. Nath V, Grewal KS (1935). Cancer in India. Ind J Med Res, 23, 149-90.
  29. Noronha V, Dikshit R, Raut N, et al (2012). Epidemiology of lung cancer in India: focus on the differences between nonsmokers and smokers: a single-centre experience. Indian J Cancer, 49, 74-81. https://doi.org/10.4103/0019-509X.98925
  30. Offit K, Brown K (1994). Quantitating familial cancer risk: a resource for clinical oncologists. J Clin Oncol, 12, 1724-36. https://doi.org/10.1200/JCO.1994.12.8.1724
  31. Peto R (1994). Smoking and death: the past 40 years and the next 40. BMJ, 309, 937. https://doi.org/10.1136/bmj.309.6959.937
  32. Prasad R, James P, Kesarwani V, et al (2004). Clinicopathological study of bronchogenic carcinoma. Respirol, 9, 557-60. https://doi.org/10.1111/j.1440-1843.2004.00600.x
  33. Rajasekaran S, Manickam TG, Visanthan PJ, et al (1993). Pattern of primary lung cancer: a Madras study. Lung India, 11, 7-11.
  34. Sheikh S, Shah A, Arshed A, et al (2010). Histological pattern of primary malignant lung tumours diagnosed in a tertiary care hospital: 10 year study. Asian Pac J Cancer Prev, 11, 1341-6.
  35. Sherman CB (1991). Health effects of cigarette smoking. Clin Chest Med, 12, 643-58.
  36. Thippana G, Venu K, Gopal KV, et al (1999). A profile of lung cancer patients in Hyderabad. J Indian Med Assoc, 97, 357-359.
  37. Travis WD (2004). World Health Organization Classification of Tumours, Lyon, IARC Press.
  38. Vishwanathan R, Gupta Sen, Krishna PV (1962). Incidence of primary lung cancer in India. Thorax, 17, 73-76. https://doi.org/10.1136/thx.17.1.73
  39. Wingo PA, Ries LA, Giovino GA, et al (1999). Annual report to the nation on the status of cancer, 1973-1996, with a special section on lung cancer and tobacco smoking. J Natl Cancer Inst, 91, 675-90. https://doi.org/10.1093/jnci/91.8.675
  40. Weiss W, Boucot KR, Seidman H (1982). The philadelphia pulmonary neoplasm research project. Clin Chest Med, 3, 243-56.

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