Spectrum of Cytological Findings in Fine Needle Aspiration Cytology of Breast Lumps with Histopathology Correlation: Experience in a Tertiary Care Rural Hospital in India

  • Published : 2013.12.31


To determine the pattern of disease in patients presenting with breast lumps and to determine the sensitivity and specificity of fine needle aspiration cytology of benign and malignant diseases as a diagnostic tool by correlating with histopathology findings. This retrospective study was carried out in the Department of Pathology, Maharaja Agrasen Medical College, Agroha, from Jan 2008 to April 2012. Fine needle aspiration cytology was performed on 370 cases and out of these 52 cases were received in the Department for histopathological examination. Fibroadenoma was the most common disease encountered, in 88 (24%), with a peak incidence in second and third decade of life. Fibrocystic disease was second, being common in the third and fourth decades of life. Peak incidences of duct ectasia, granulomatous and tubercular mastitis were seen in the third decade. Gynaecomastia showed two peak incidences in second and sixth decades of life. Out of total 370 cases undergoing fine needle aspiration, benign cases were 316 (85.4%), malignant and suspicious were 54 (14.6%) and 10 (2.70%) respectively. Out of total 22 histological confirmed malignant lesions 19 were interpreted as malignant cytologically while two as suspicious and one as benign. All thirty histologically confirmed benign cases were diagnosed as benign cytologically. The sensitivity, specificity, positive and negative predictive values were 98%, 100%, 100% and 96.4% respectively. FNA cytology is highly accurate for diagnosis of breast masses. However, the clinician should correlate FNA cytological results with physical examination and imaging findings to prevent false negative and false positive events and to obtain optimal management of their patients.


  1. AAbdullah P, Mubarik A, Zahir N (1999). Breast lump what they actually represent. J Coll Physicians Surg Pak, 9, 46-8.
  2. Ahmed I, NazirR, Chaudhary MY, et al (2007). Triple assessment of breast lump. J Coll Physician Surg Pak, 17, 535-8.
  3. Akhator A (2007). Benign breast masses in Nigeria. Nig J Surg Sci, 17, 105-8.
  4. Argia R, Bloom K, Reddy VB, et al (2002). Fine Needle Aspiration of clinically suspicious palpable breast masses with histopathologic correlation. Am J Surg, 184, 410-3.
  5. Hussain MT (2005). Comparison of fine needle aspiration cytology with excision biopsy of breast lump. J Coll Physicians Surg Pak, 15, 211-4.
  6. Irabor DO (2008). An audit of 149 consecutive breast biopsies in Ibadan, Nigeria. Pak J Med Sci, 24, 257-2
  7. Ishikawa T, Hamaguchi Y, Tanabe M, et al (2007). False positive and false negative cases of fine needle aspiration cytology for breast lesions. Breast Carcinoma, 14, 388-2.
  8. Iyer SP (2000). Epidemiology of benign breast diseases in females of childbearing age group. Bombay Hosp J, 42, 10.
  9. Jayaram G, Alhady SF, Yip CH (1996). Cytotogical analysis of breast lesions: a review of 780 cases. Malaysian J Pathol, 18, 81-7.
  10. Khanzada TW, Samad A, Sushel C (2009). Spectrum of benign breast diseases. Pak J Med Sci, 25, 265-8.
  11. Khemkha A, Chakrabarti N, Shah S, et al (2009). Palpable breast lumps: fine needle aspiration cytology versus histopathology: a correlation of diagnostic accuracy. Internet J Surg, 18, 1.
  12. Muhamed AZ, Edino ST, Ochicha O, Alhasan Su (2005). The value of fine needle aspiration biopsy in preoperative diagnosis of palpable breast lumps in resource-poor countries. Ann Afr Med, 4, 19-2
  13. Nastui JF, Gupta PK, Baloch ZW (2002). Diagnostic value and cost-effectiveness of on-siteevaluation of fine needle aspiration specimens review of 5, 688 cases. Diag Cytopathol, 27, 1-4
  14. Ochicha O (2002). Benign breast lesions in Kano. Nigerian J Surg Res, 4, 1-5.
  15. Rubin J, Horiuchi K, Joy N, et al (1997). Use of FNAC for solid breast lesions is accurate and cost effevtive. Am J Surg, 174, 694-6.
  16. Siddiqui MS (2003). Breast diseases - a histopathological analysis of 3279 cases at a tertiary care centre in Pakistan. J Pakistan Med Assoc, 53, 5.
  17. Singh A, Haritwal A, Murali BM (2011). Pattern of breast lumps and diagnostic accuracy of fine needle aspiration cytology; a hospital based study from Pondicherry, India. Internet J Pathol, 11, 2.

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