Intra-operative Rectal Washout with Saline Solution Can Effectively Prevent Anastomotic Recurrence: a Meta-analysis

  • Zhou, Can (Department of Centre of Translational Medicine, the First Affiliated Hospital of Xi'an Jiaotong University) ;
  • Ren, Yu (Department of Surgical Oncology, the First Affiliated Hospital of Xi'an Jiaotong University) ;
  • Wang, Ke (Department of Surgical Oncology, the First Affiliated Hospital of Xi'an Jiaotong University) ;
  • Liu, Jie (Department of Centre of Translational Medicine, the First Affiliated Hospital of Xi'an Jiaotong University) ;
  • He, Jian-Jun (Department of Surgical Oncology, the First Affiliated Hospital of Xi'an Jiaotong University) ;
  • Liu, Pei-Jun (Department of Centre of Translational Medicine, the First Affiliated Hospital of Xi'an Jiaotong University)
  • Published : 2013.12.31


Background and Objective: Rectal washout with saline solution may theoretically prevent anastomotic recurrence in patients with resectable rectal cancer, although exact clinical effects have not yet been determined. In order to derive a more precise estimation of the relationship, the present meta-analysis was performed. Method: Relevant studies were identified by a search of Medline, Embase and Google Website with no restrictions to September 1, 2013, and included in the systematic review and meta-analysis. Results: 5 trials (642 participants) were included to assess the association between rectal washout with saline solution and anastomotic recurrence. The rate of anastomotic recurrence (AR) was 6.23% (40/642), with the pooled OR derived from the five studies being 0.32 (95 % CI=0.15-0.70, P=0.004). The pooled OR derived from the TME and radical resection subgroups were 0.72 (95%CI=0.16-3.12, P=0.66) and 0.51 (95%CI=0.13-1.96, P=0.32), respectively. Conclusion: Results from this analysis show that intra-operative rectal washout with mere saline solution largely reduces the risk of anastomotic recurrences in patients with resectable rectal cancer.


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