- Volume 14 Issue 11
DOI QR Code
Polymorphisms in XRCC1 Gene, Alcohol drinking, and Risk of Colorectal Cancer: a Case-control Study in Jiangsu Province of China
- Gao, Chang-Ming (Division of Epidemiology, Jiangsu Province Institute of Cancer Research) ;
- Ding, Jian-Hua (Division of Epidemiology, Jiangsu Province Institute of Cancer Research) ;
- Li, Su-Ping (Division of Epidemiology, Jiangsu Province Institute of Cancer Research) ;
- Liu, Yan-Ting (Division of Epidemiology, Jiangsu Province Institute of Cancer Research) ;
- Cao, Hai-Xia (Division of Epidemiology, Jiangsu Province Institute of Cancer Research) ;
- Wu, Jian-Zhong (Division of Epidemiology, Jiangsu Province Institute of Cancer Research) ;
- Tang, Jin-Hai (Division of Epidemiology, Jiangsu Province Institute of Cancer Research) ;
- Tajima, Kazuo (Dept. of Public Health & Occupational Medicine, Mie University Graduate School of Medicine)
- Published : 2013.11.30
To evaluate the relationship between alcohol drinking, XRCC1 codon 194 and 399 polymorphisms and risk of colorectal cancer, we conducted a case-control study with 315 colorectal cancer cases (105 colon, 210 rectal) and 439 population-based controls in Jiangsu Province of China. The XRCC1 codon 194 and 399 genotypes were identified using polymerase chain reaction and restrictrion fragment length polymorphism methods (PCR-RFLP). A structured questionnaire was used to elicit detailed information. Odds ratios (ORs) were estimated with an unconditional logistic model. In this study no significant differences were observed among the studied groups with regard to the genotype distribution of the XRCC1 codons 194 and 399 and the risk of colorectal cancer did not appear to be significantly influenced by genotype alone, whereas alcohol consumption showed a positive association (P for trend <0.01). When combined effects of XRCC1 polymorphisms and alcohol consumption were analyzed, we found that the 194Trp or 399Gln alleles further increased the colorectal cancer risk due to high alcohol intake. These findings support the conclusion that colorectal cancer susceptibility may be altered by gene-environment interactions.
Colorectal cancer;XRCC1;gene polymorphisms;alcohol drinking;susceptibility
- Abdel-Rahman SZ, Soliman AS, Bondy ML, et al (2000). Inheritance of the 194Trp and the 399Gln variant alleles of the DNA repair gene XRCC1 are associated with increased risk of early-onset colorectal carcinoma in Egypt. Cancer Lett, 159, 79-86. https://doi.org/10.1016/S0304-3835(00)00537-1
- Blasiac J (2001). Ethanol and acetaldehyde impair the repair of bleomycin-damaded DNA in human lymphocytes. Cytobios, 106, 141-9.
- Brooks PJ (1997). DNA damage, DNA repair, and alcohol toxicity-a review. Alcohol Clin Exp Res, 21, 1073-82.
- Brooks PJ, Theruvathu JA (2005). DNA adducts from acetaldehyde: implications for alcohol-related carcinogenesis. Alcohol, 35, 187-93. https://doi.org/10.1016/j.alcohol.2005.03.009
- Canbay E, Cakmakoglu B, Zeybek U, et al (2011). Association of APE1 and hOGG1 polymorphisms with colorectal cancer risk in a Turkish population. Curr Med Res Opin, 27, 1295-302. https://doi.org/10.1185/03007995.2011.573544
- Cao HX, Gao CM, Takezaki T, et al (2008). Genetic Polymorphisms of Methylenetetrahydrofolate Reductase and Susceptibility to Colorectal Cancer. Asian Pacific J Cancer Prev, 9, 203-8.
- Curtin K, Samowitz WS, Wolff RK, et al (2009). Assessing tumor mutations to gain insight into base excision repair sequence polymorphisms and smoking in colon cancer. Cancer Epidemiol Biomarkers Prev, 18, 3384-88. https://doi.org/10.1158/1055-9965.EPI-09-0955
- Gao CM, Gong JP, Wu JZ, et al (2010). Relationship between growth hormone 1 genetic polymorphism and susceptibility to colorectal cancer. J Human Genetics, 55, 163-6. https://doi.org/10.1038/jhg.2010.3
- Gsur A, Bernhart K, Baierl A, et al (2011). No association of XRCC1 polymorphisms Arg194Trp and Arg399Gln with colorectal cancer risk. Cancer Epidemiol, 35, e38-41. https://doi.org/10.1016/j.canep.2011.03.005
- Hoek JB, Pastorino JG (2002). Ethanol, oxidative stress, and cytokineinduced liver cell injury. Alcohol, 27, 63-8. https://doi.org/10.1016/S0741-8329(02)00215-X
- Hong YC, Lee KH, Kim WC, (2005). Polymorphisms of XRCC1 gene, alcohol consumption and colorectal cancer. Int J Cancer, 116, 428-32. https://doi.org/10.1002/ijc.21019
- Hsieh LL, Chien HT, Chen IH, et al (2003). The XRCC1 399Gln polymorphism and the frequency of p53 mutations in Taiwanese oral squamous cell carcinomas. Cancer Epidemiol Biomarkers Prev, 12, 439-43.
- Improta G, Sgambato A, Bianchino G, et al (2008). Polymorphisms of the DNA repair genes XRCC1 and XRCC3 and risk of lung and colorectal cancer: a case-control study in a Southern Italian population. Anticancer Res, 28(5B), 2941-46.
- Jelonek K, Gdowicz-Klosok A, Pietrowska M, et al (2012). Association between single-nucleotide polymorphisms of selected genes involved in the response to DNA damage and risk of colon, head and neck, and breast cancers in a Polish population. J Appl Genet, 51, 343-52.
- Jin MJ, Chen K, Zhang Y, et al (2007).Correlations of single nucleotide polymorphisms of DNA repair gene XRCC1 to risk of colorectal cancer. Ai Zheng, 26, 274-9.
- Jin MJ, Liu B, Zhang SS, et al (2008). Application of multifactor dimensionality reduction on the interactions between gene-gene, gene-environment and the risk sporadic colorectal cancer in Chinese population. Zhongguo Liu Xing Bing Xue Za Zhi, 29, 535-9.
- Karahalil B, Bohr VA, Wilson DM (2012). Impact of DNA polymorphisms in key DNA base excision repair proteins on cancer risk. Hum Exp Toxicol, 31, 981-1005. https://doi.org/10.1177/0960327112444476
- Kasahara M, Osawa K, Yoshida K, et al (2008). Association of MUTYH Gln324His and APEX1 Asp148Glu with colorectal cancer and smoking in a Japanese population. J Exp Clin Cancer Res, 27, 49. https://doi.org/10.1186/1756-9966-27-49
- Muniz-Mendoza R, Ayala-Madrigal ML, Partida-Perez M, et al (2012). MLH1 and XRCC1 polymorphisms in Mexican patients with colorectal cancer. Genet Mol Res, 11, 2315-20. https://doi.org/10.4238/2012.June.27.6
- Reeves SG, Meldrum C, Groombridge C, et al (2012). Spigelman A, Suchy J, Kurzawski G, Lubinski J, Scott RJ.DNA repair gene polymorphisms and risk of early onset colorectal cancer in Lynch syndrome. Cancer Epidemiol, 36, 183-9. https://doi.org/10.1016/j.canep.2011.09.003
- Shen MR, Jones IM, Mohrenweiser H (1998). Nonconservative amino acid substitution variants exist at polymorphic frequency in DNA repair genes in healthy humans. Cancer Res, 58, 604-8.
- Stern MC, Conti DV, Siegmund KD, et al (2007). DNA repair single-nucleotide polymorphisms in colorectal cancer and their role as modifiers of the effect of cigarette smoking and alcohol in the Singapore Chinese Health Study. Cancer Epidemiol Biomarkers Prev, 16, 2363-72. https://doi.org/10.1158/1055-9965.EPI-07-0268
- Wang J, Zhao Y, Jiang J, et al (2010). Polymorphisms in DNA repair genes XRCC1, XRCC3 and XPD, and colorectal cancer risk: a case-control study in an Indian population. J Cancer Res Clin Oncol, 136, 1517-25. https://doi.org/10.1007/s00432-010-0809-8
- Yeh CC, Hsieh LL, Tang R, et al (2005). MS-920: DNA repair gene polymorphisms, diet and colorectal cancer risk in Taiwan. Cancer Lett, 224, 279-88. https://doi.org/10.1016/j.canlet.2005.01.029
- Yin G, Morita M, Ohnaka K, et al (2012). Genetic polymorphisms of XRCC1, alcohol consumption, and the risk of colorectal cancer in Japan. J Epidemiol, 22, 64-71. https://doi.org/10.2188/jea.JE20110059
- Down-regulated MYH11 Expression Correlates with Poor Prognosis in Stage II and III Colorectal Cancer vol.15, pp.17, 2014, https://doi.org/10.7314/APJCP.2014.15.17.7223
- A Volunteer Alcohol Consumption Reduction Campaign: Participatory Action Research among Thai Women in the Isaan Region vol.15, pp.17, 2014, https://doi.org/10.7314/APJCP.2014.15.17.7343
- Association between co-inhibitory molecule gene tagging single nucleotide polymorphisms and the risk of colorectal cancer in Chinese vol.141, pp.9, 2015, https://doi.org/10.1007/s00432-015-1915-4
- Over Expression of BCL2 and Low Expression of Caspase 8 Related to TRAIL Resistance in Brain Cancer Stem Cells vol.16, pp.12, 2015, https://doi.org/10.7314/APJCP.2015.16.12.4849
- Polymorphism of the DNA Repair Gene XRCC1 (Arg194Trp) and its role in Colorectal Cancer in Kashmiri Population: a Case Control Study vol.16, pp.15, 2015, https://doi.org/10.7314/APJCP.2015.16.15.6385
- XRCC1 R399Q polymorphism and colorectal cancer risk in the Chinese Han population: a meta-analysis vol.36, pp.2, 2015, https://doi.org/10.1007/s13277-015-3054-6
- Moderate Alcohol Consumption and Colorectal Cancer Risk vol.39, pp.8, 2015, https://doi.org/10.1111/acer.12778
- The XRCC 1 DNA repair gene modifies the environmental risk of stomach cancer: a hospital-based matched case-control study vol.17, pp.1, 2017, https://doi.org/10.1186/s12885-017-3675-9
- Lack of correlation between X-ray repair cross-complementing group 1 gene polymorphisms and the susceptibility to colorectal cancer in a Malaysian cohort vol.26, pp.6, 2017, https://doi.org/10.1097/CEJ.0000000000000336
- Alcoholic Beverage Consumption and Chronic Diseases vol.13, pp.6, 2016, https://doi.org/10.3390/ijerph13060522