- Volume 14 Issue 11
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Levels of Tobacco-specific Metabolites among Non-smoking Lung Cancer Cases at Diagnosis: Case-control Findings
- Hwang, Sang-Hyun ;
- Ryu, Hye-Jung ;
- Kang, Soo Jin ;
- Yun, E. Hwa ;
- Lim, Min Kyung ;
- Kim, Heung Tae ;
- Lee, Jin Soo ;
- Lee, Do-Hoon
- Published : 2013.11.30
Background: Environmental tobacco smoking (ETS) significantly contributes to morbidity and mortality and is a known risk factor for lung cancer development in lifelong nonsmokers. The metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and its glucuronides (NNAL-Glucs) have now emerged as leading biomarkers for the study of carcinogen exposure in non-smokers exposed to ETS. Materials and Methods: We carried out our study on NNAL in the urine of non-smokers exposed to ETS and the association between ETS and lung cancer. Subjects were enrolled from 2008-2010. NNAL was analyzed for 74 non-smoking lung cancer and 85 healthy controls. The main objective of this study was to provide an estimate of the risk of lung cancer from exposure to ETS in the Korean population. Results: The mean NNAL concentration in urine was significantly lower in non-smoking patient groups (n=74) than in control groups (n=85) (
Tobacco smoke pollution;environmental tobacco smoking;NNAL
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