Asian Pacific Journal of Cancer Prevention
- Volume 14 Issue 11
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- Pages.6549-6556
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- 2013
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- 1513-7368(pISSN)
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- 2476-762X(eISSN)
DOI QR Code
Senescence Effects of Angelica sinensis Polysaccharides on Human Acute Myelogenous Leukemia Stem and Progenitor Cells
- Liu, Jun (Histology and Embryology, Laboratory of Stem Cell and Tissue Engineering, Chongqing Medical University) ;
- Xu, Chun-Yan (Histology and Embryology, Laboratory of Stem Cell and Tissue Engineering, Chongqing Medical University) ;
- Cai, Shi-Zhong (Histology and Embryology, Laboratory of Stem Cell and Tissue Engineering, Chongqing Medical University) ;
- Zhou, Yue (Histology and Embryology, Laboratory of Stem Cell and Tissue Engineering, Chongqing Medical University) ;
- Li, Jing (Histology and Embryology, Laboratory of Stem Cell and Tissue Engineering, Chongqing Medical University) ;
- Jiang, Rong (Histology and Embryology, Laboratory of Stem Cell and Tissue Engineering, Chongqing Medical University) ;
- Wang, Ya-Ping (Histology and Embryology, Laboratory of Stem Cell and Tissue Engineering, Chongqing Medical University)
- Published : 2013.11.30
Abstract
Leukemia stem cells (LSCs) play important roles in leukemia initiation, progression and relapse, and thus represent a critical target for therapeutic intervention. Hence, it is extremely urgent to explore new therapeutic strategies directly targeting LSCs for acute myelogenous leukemia (AML) therapy. We show here that Angelica sinensis polysaccharide (ASP), a major active component in Dong quai (Chinese Angelica sinensis), effectively inhibited human AML
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References
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