DOI QR코드

DOI QR Code

Very Young Breast Cancer in a Referral Center in Tehran, Iran: Review of 55 Cases Aged 25 or Less throughout 33 Years

  • Alipour, Sadaf (Surgery Department - Cancer Institute and Arash Women's Hospital, Tehran University of Medical Sciences) ;
  • Omranipour, Ramesh (Surgery Department, Cancer Institute, Tehran University of Medical Sciences) ;
  • Jahanzad, Issa (Pathology Department, Cancer Institute, Tehran University of Medical Sciences) ;
  • Bagheri, Khojasteh (Breast Clinic, Cancer Institute, Tehran University of Medical Sciences)
  • Published : 2013.11.30

Abstract

Background: Breast cancer is mostly the disease of postmenopausal women but very young affected women are seen more than occasionally in developing countries. We reviewed our cases of very young breast cancer in order to help in better understanding of such cases. Materials and Methods: The records of patients 25 years of age or less who had been admitted for breast cancer surgery in the Cancer Institute of Tehran from 1979 to 2012 were reviewed and relevant data were extracted. Results: From 5,265 cases of breast cancer, 62 patients had 25 years of age or less. There were 55 cases of breast adenocarcinoma, all female. More than 78% of the patients had presented with a palpable mass, the family history was positive in 2% of cases, and about 94% of the histologies were invasive ductal carcinoma. Gestational breast cancer constituted 10% of the cancers; another 10%were bilateral. The median size of the tumors was 5.72 centimeters, 63.2% of them had axillary lymphatic involvement, and more than half were negative for hormone receptors. Conclusions: Our study shows an incidence of 1.17% for very young breast cancer and a 10% rate of bilaterality which probably warrants special guidelines for contralateral screening. Cancer stage and features were poor in comparison with breast cancer in all ages.

Keywords

Breast cancer;very young females;incidence;Iran

References

  1. Anders CK, Johnson R, Litton J, Phillips M, Bleyer A (2009). Breast cancer before age 40 years. Semin Oncol, 36, 237-49. https://doi.org/10.1053/j.seminoncol.2009.03.001
  2. Andre C, Collignon J, Rorive A, et al (2011). Breast cancer in young women. Rev Med Liege, 66, 397-9.
  3. Bidgoli SA, Ahmadi R, Zavarhei MD (2010). Role of hormonal and environmental factors on early incidence of breast cancer in Iran. Sci Total Environ, 408, 4056-61. https://doi.org/10.1016/j.scitotenv.2010.05.018
  4. Dixon JM BN (2010). Management of disorders of the ductal system and infections. in 'diseases of the breast', Eds Harris JR LM, Morrow M,Osborne CK. 4th ed. Wolters Kluwer, Lippincott Williams&Wilkins,USA pp 42-5.
  5. Dor J, Lerner-Geva L, Rabinovici J, et al (2002). Cancer incidence in a cohort of infertile women who underwent in vitro fertilization. Fertility and Sterility, 77, 324-7. https://doi.org/10.1016/S0015-0282(01)02986-7
  6. Gabriel CA, Domchek SM (2010). Breast cancer in young women. Breast Cancer Res, 12, 212. https://doi.org/10.1186/bcr2647
  7. Harirchi I, Karbakhsh M, Kashefi A, Momtahen AJ (2004). Breast cancer in Iran: results of a multi-center study. Asian Pac J Cancer Prev, 5, 24-7.
  8. Harirchi I, Karbakhsh M, Montazeri A, et al (2010). Decreasing trend of tumor size and downstaging in breast cancer in Iran: results of a 15-year study. Eur J Cancer Prev, 19, 126-30. https://doi.org/10.1097/CEJ.0b013e328333d0b3
  9. Harirchi I, Kolahdoozan S, Karbakhsh M, et al (2011). Twenty years of breast cancer in Iran: downstaging without a formal screening program. Ann Oncol, 22, 93-7. https://doi.org/10.1093/annonc/mdq303
  10. Hunt KK NL, Copeland III EM, Bland KL (2010). The Breast. In 'Schwartz's Principles of Surgery', Eds Brunicardi FC AD, Billiar TR, Dunn DL, et al. 9th ed. McGraw-Hill, USA pp 424-6.
  11. Keegan TH, Derouen MC, Press DJ, Kurian AW, Clarke CA (2012). Occurrence of breast cancer subtypes in adolescent and young adult women. Breast Cancer Res, 14, 55.
  12. Keinan-Boker L, Lerner-Geva L, Kaufman B, Meirow D (2008). Pregnancy-associated breast cancer. Isr Med Assoc J, 10, 722-7.
  13. Kolahdoozan S, Sadjadi A, Radmard AR, Khademi H (2010). Five common cancers in Iran. Arch Iran Med, 13, 143-6.
  14. Lerner-Geva L, Geva E, Lessing JB et al (2003). The possible association between in vitro fertilization treatments and cancer development. Int J Gynecol Cancer, 13, 23-7. https://doi.org/10.1046/j.1525-1438.2003.13041.x
  15. Merlo DF, Ceppi M, Filiberti R, et al (2012). Breast cancer incidence trends in European women aged 20-39 years at diagnosis. Breast Cancer Res and Treatment, 134, 363-70. https://doi.org/10.1007/s10549-012-2031-7
  16. Mousavi SM, Mohagheghi MA, Mousavi-Jerrahi A, Nahvijou A, Seddighi Z (2008). Outcome of breast cancer in Iran: a study of Tehran Cancer Registry data. Asian Pac J Cancer Prev, 9, 275-8.
  17. Mousavi SM, Montazeri A, Mohagheghi MA, et al (2007). Breast cancer in Iran: an epidemiological review. Breast J, 13, 383-91. https://doi.org/10.1111/j.1524-4741.2007.00446.x
  18. Pourzand A, Fakhree MB, Hashemzadeh S, Halimi M, Daryani A (2011). Hormone receptor status in breast cancer and its relation to age and other prognostic factors. Breast Cancer (Auckl), 5, 87-92.
  19. Robles-Castillo J, Ruvalcaba-Limon E, Maffuz A, Rodriguez-Cuevas S (2011). Breast cancer in Mexican women under 40. Ginecol Obstet Mex, 79, 482-8.
  20. Saleh FM, Ansari NP (2012). Invasive ductal carcinoma in a young male breast. Mymensingh Med J, 21, 162-4.
  21. Shulman LN, Willett W, Sievers A, Knaul FM (2010). Breast cancer in developing countries: opportunities for improved survival. J Oncol, 2010, 595167.
  22. Yang H, Wang SY, Ou W, Sun HB, Fang Q (2009). Clinical characteristics and prognosis of very young patients with breast cancer in the southern of China. Ai Zheng, 28, 1310-6.

Cited by

  1. OM.Breast Cancer in Very Young Women Aged 25 Year-Old or Below in the Center of Tunisia and Review of the Literature vol.21, pp.3, 2015, https://doi.org/10.1007/s12253-015-9944-5