DOI QR코드

DOI QR Code

MUTYH Association with Esophageal Adenocarcinoma in a Han Chinese Population

  • Kong, Feng (Central Research Laboratory, The Second Hospital of Shandong University) ;
  • Han, Xue-Ying (Jinan Blood Station, Blood Center of Shandong Province) ;
  • Luan, Yun (Central Research Laboratory, The Second Hospital of Shandong University) ;
  • Qi, Tong-Gang (Central Research Laboratory, The Second Hospital of Shandong University) ;
  • Sun, Chao (Central Research Laboratory, The Second Hospital of Shandong University) ;
  • Wang, Jue (Central Research Laboratory, The Second Hospital of Shandong University) ;
  • Hou, Hua-Ying (Oncology Department, The Second Hospital of Shandong University) ;
  • Jiang, Yu-Hua (Oncology Department, The Second Hospital of Shandong University) ;
  • Zhao, Jing-Jie (Molecular Biology Laboratory, The Second Hospital of Shandong University) ;
  • Cheng, Guang-Hui (Central Research Laboratory, The Second Hospital of Shandong University)
  • Published : 2013.11.30

Abstract

Adenocarcinoma of esophagus (AE) is a complex disease, affected by a variety of genetic and environmental factors. Much evidence has shown that the MutY glycosylase homologue (MUTYH) plays a key role in the pathogenesis of many cancers. However, there have been no reports on influence on AE in the Han Chinese population. The objective of this study was to investigate this issue. A gene-based association study was conducted using three single nucleotide polymorphisms(SNPs) reported in previous studies. The three SNPs (rs3219463, rs3219472, rs3219489) were genotyped in 207 unrelated AE patients and 249 healthy controls in a case-control study using polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). The results revealed that the genotype distribution of rs3219472 differed between the case and control groups (OR=1.66,95%CI=1.11-2.48, P=0.012), indicating that an association may exist between MUTYH and AE. These findings support a signifcant role for MUTYH in AE pathogenesis in the Han Chinese population.

Keywords

MUTYH;adenocarcinoma of esophagus;SNPs;PCR-RFLP;association study

References

  1. Brand R, Nielsen M, Lynch H, Infante E (2012). MUTYH-Associated Polyposis. $GeneReviews^{TM}$ [Internet].
  2. Cheng G, Wang H, Chen M, et al (2011). Lack of evidence to support the association of polymorphisms within the TNFSF4 gene and coronary heart disease in a Chinese Han population. Exp Ther Med, 2, 275-280. https://doi.org/10.3892/etm.2010.188
  3. Gu H, Ding G, Zhang W, et al (2012). Replication study of PLCE1 and C20orf54 polymorphism and risk of esophageal cancer in a Chinese population. Mol Biol Rep, 39, 9105-11. https://doi.org/10.1007/s11033-012-1782-x
  4. Markkanen E, Dorn J, Hubscher U (2013). MUTYH DNA glycosylase: the rationale for removing undamaged bases from the DNA. Front Genet, 4, 18.
  5. Miyaishi A, Osawa K, Osawa Y, et al (2009). MUTYH Gln324His gene polymorphism and genetic susceptibility for lung cancer in a Japanese population. J Exp Clin Cancer Res, 28, 10. https://doi.org/10.1186/1756-9966-28-10
  6. Picelli S, Zajac P, Zhou XL, et al (2010). Common variants in human CRC genes as low-risk alleles. Eur J Cancer, 46, 1041-8. https://doi.org/10.1016/j.ejca.2010.01.013
  7. Przybylowska K, Kabzinski J, Sygut A, et al (2013). An association selected polymorphisms of XRCC1, OGG1 and MUTYH gene and the level of efficiency oxidative DNA damage repair with a risk of colorectal cancer. Mutat Res, 745-746, 6-15. https://doi.org/10.1016/j.mrfmmm.2013.04.002
  8. Ruggieri V, Pin E, Russo MT, et al (2012). Loss of MUTYH function in human cells leads to accumulation of oxidative damage and genetic instability. Oncogene, 32, 4500-8.
  9. Santos LS, Branco SC, Silva SN, et al (2012). Polymorphisms in base excision repair genes and thyroid cancer risk. Oncol Rep, 28, 1859-68. https://doi.org/10.3892/or.2012.1975
  10. Sliwinski T, Markiewicz L, Rusin P, et al (2009). Polymorphisms of the DNA base excision repair gene MUTYH in head and neck cancer. Exp Oncol, 31, 57-9.
  11. Stanczyk M, Sliwinski T, Cuchra M, et al (2011). The association of polymorphisms in DNA base excision repair genes XRCC1, OGG1 and MUTYH with the risk of childhood acute lymphoblastic leukemia. Mol Biol Rep, 38, 445-51. https://doi.org/10.1007/s11033-010-0127-x
  12. Torrezan GT, da Silva FC, Santos EM, et al (2013). Mutational spectrum of the APC and MUTYH genes and genotype-phenotype correlations in Brazilian FAP, AFAP, and MAP patients. Orphanet J Rare Dis, 8, 54. https://doi.org/10.1186/1750-1172-8-54
  13. You SH, Wang X, Huang S, et al (2013). MYH rs3219476 and rs3219472 polymorphisms and risk of cholangiocarcinoma. Mol Med Rep, 7, 347-51 https://doi.org/10.3892/mmr.2012.1175

Cited by

  1. The Association between O(6)-Methylguanine DNA Methyltransferase (MGMT) rs11016879 and rs7069143 Polymorphisms and Susceptibility to Еsophageal Аdenocarcinoma in a Han Chinese Population vol.54, pp.4, 2018, https://doi.org/10.1134/S1022795418040063