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Prognostic Significance of Interactions Between ER Alpha and ER Beta and Lymph Node Status in Breast Cancer Cases

  • Han, Shu-Jing (Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University) ;
  • Guo, Qing-Qing (Beijing Friend Hospital, Capital University of Medical Sciences) ;
  • Wang, Ting (Departments of General Surgery, Xinjing Hospital, Xi'an) ;
  • Wang, You-Xin (Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University) ;
  • Zhang, Yu-Xiang (Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University) ;
  • Liu, Fen (Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University) ;
  • Luo, Yan-Xia (Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University) ;
  • Zhang, Jie (Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University) ;
  • Wang, You-Li (Peking University People's Hospital) ;
  • Yan, Yu-Xiang (Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University) ;
  • Peng, Xiao-Xia (Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University) ;
  • Ling, Rui (Departments of General Surgery, Xinjing Hospital, Xi'an) ;
  • He, Yan (Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University)
  • Published : 2013.10.30

Abstract

Objective: Both estrogen receptors, ER alpha ($ER{\alpha}$) and ER beta ($ER{\beta}$), are expressed in 50-70% of breast cancer cases. The role of $ER{\alpha}$ as a prognostic marker in breast cancer has been well established as its expression is negative correlated with tumor size and lymph node metastasis. $ER{\beta}$ is also a favorable prognostic predictor although this is less well documented than for $ER{\alpha}$. Materials and Methods: To explore whether ERs independently or together might influence clinical outcome in breast cancer, the correlation between the ERs with the clinicopathological features was analyzed in 84 patients. Results: $ER{\alpha}$ expression negatively correlated with tumor stage (r=-0.246, p=0.028) and tended to be negatively correlated with lymph node status (r=-0.156, p=0.168) and tumor size (r=-0.246, p=0.099). Also, $ER{\beta}$ was negatively correlated with nodal status (r=-0.243, p=0.028), as was coexpression of $ER{\alpha}$ and $ER{\beta}$ (p=0.043, OR=0.194, 95% CI= 0.040-0.953). Conclusion: Coexpression of ERs might serve as an indicator of good prognosis in breast cancer patients.

Keywords

Breast cancer;ER alpha;ER beta;interaction;lymph node;metastasis

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