DOI QR코드

DOI QR Code

Increase in the Rate of HPV Positive Oropharyngeal Cancers During 1996-2011 in a Case Study in Turkey

  • Tural, Deniz (Akdeniz University, Medical Faculty, Department of Internal Medicine, Division of Medical Oncology) ;
  • Elicin, Olgun (Department of Radiation Oncology, Division of Medical Oncology, Istanbul University, Cerrahpasa Medical Faculty) ;
  • Batur, Sebnem (Department of Pathology, Division of Medical Oncology, Istanbul University, Cerrahpasa Medical Faculty) ;
  • Arslan, Deniz (Akdeniz University, Medical Faculty, Department of Internal Medicine, Division of Medical Oncology) ;
  • Oz, Buge (Department of Pathology, Division of Medical Oncology, Istanbul University, Cerrahpasa Medical Faculty) ;
  • Serdengecti, Suheyla (Department of Internal Medicine, Division of Medical Oncology, Istanbul University, Cerrahpasa Medical Faculty) ;
  • Uzel, Omer (Akdeniz University, Medical Faculty, Department of Internal Medicine, Division of Medical Oncology)
  • Published : 2013.10.30

Abstract

Background: Primary aim of this study is to assess whether or not there is an increase at rate of HPV positive oropharyngeal cancers during 1996-2011 in Turkey, for comparison with prior reports from Western countries. Materials and Methods: A total of 138 newly diagnosed patients with oropharyngeal cancer were identified, 39 of which had no primary tumor specimen available and 18 patients with invalid HPV status, therefore HPV status for remaining 81 patients was evaluated. The presence and type of HPV DNA were determined with formalin-fixed paraffin embedded specimens, using an HPV DNA-based multiplex PCR assay. Associations between HPV status and clinicopathological characteristics were evaluated using a two-sample t-test for the continuous variables and the categorical variables were compared by chi-square test. Overall survival (OS) periods were calculated with Kaplan-Meier method. Results: The proportion of HPV-positive cancer has continued to increase during 2004-2011 as compared with 1996-2003. Notably, 33% (6/18) of the cases were HPV-positive in 1996-1999, 43% (9/21) in 2000-2003, 55% (11/20) in 2004-2007 and 70% (16/23) in 2008-2011. Thus, when we compared the results obtained during the 2004-2011with results of 1996-2003 period, we found that increase at HPV-positivity ratio was statistically significant (38% vs 64% p=0.012). Conclusions: This study demonstrated that HPV positive oropharyngeal cancers are increasing in Turkish patients as in the Western world.

Keywords

Oropharyngeal cancer;HPV status;incidence;Turkey

References

  1. D'Souza G, Kreimer AR, Viscidi R, et al (2007). Case-control study of human papillomavirus and oropharyngeal cancer. N Engl J Med, 356, 1944-56. https://doi.org/10.1056/NEJMoa065497
  2. Ang KK, Harris J, Wheeler R, et al (2010). Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med, 363, 24-35. https://doi.org/10.1056/NEJMoa0912217
  3. Chaturvedi AK, Engels EA, Pfeiffer RM, et al (2011). Human papillomavirus and rising oropharyngeal cancer incidence in the United States. J Clin Oncol, 29, 4294-301. https://doi.org/10.1200/JCO.2011.36.4596
  4. Gillison ML, Shah KV (2001). Human papillomavirus-associated head and neck squamous cell carcinoma: mounting evidence for an etiologic role for human papillomavirus in a subset of head and neck cancers. Curr Opin Oncol, 13, 183-8. https://doi.org/10.1097/00001622-200105000-00009
  5. Huang SH, Perez-Ordonez B, Liu FF, et al (2012). Atypical clinical behavior of p16-confirmed HPV-related oropharyngeal squamous cell carcinoma treated with radical radiotherapy. Int J Radiat Oncol Biol Phys, 82, 276-83. https://doi.org/10.1016/j.ijrobp.2010.08.031
  6. Gillison ML, D'Souza G, Westra W, et al (2008). Distinct risk factor profiles for human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck cancers. J Natl Cancer Inst, 100, 407-20. https://doi.org/10.1093/jnci/djn025
  7. Huang H, Zhang B, Chen W, et al (2012). Human papillomavirus infection and prognostic predictors in patients with oropharyngeal squamous cell carcinoma. Asian Pac J Cancer Prev, 13, 891-6. https://doi.org/10.7314/APJCP.2012.13.3.891
  8. Hobbs CG, Sterne JA, Bailey M, et al (2006). Human papillomavirus and head and neck cancer: a systematic review and meta-analysis. Clin Otolaryngol, 31, 259-66. https://doi.org/10.1111/j.1749-4486.2006.01246.x
  9. Kreimer AR, Clifford GM, Boyle P, et al (2005). Human papillomavirus types in head and neck squamous cell carcinomas worldwide: a systematic review. Cancer Epidemiol Biomarkers Prev, 14, 467-75. https://doi.org/10.1158/1055-9965.EPI-04-0551
  10. Klussmann JP, Weissenborn SJ, Wieland U, et al (2001). Prevalence, distribution, and viral load of human papillomavirus 16 DNA in tonsillar carcinomas. Cancer, 92, 2875-84. https://doi.org/10.1002/1097-0142(20011201)92:11<2875::AID-CNCR10130>3.0.CO;2-7
  11. Mork J, Lie AK, Glattre E, et al (2001). Human papillomavirus infection as a risk factor for squamous-cell carcinoma of the head and neck. N Engl J Med, 344, 1125-31. https://doi.org/10.1056/NEJM200104123441503
  12. Romanitan M, Nasman A, Ramqvist T, et al (2008). Human papillomavirus frequency in oral and oropharyngeal cancer in Greece. Anticancer Res, 28, 2077-80.
  13. Smith EM, Ritchie JM, Summersgill KF, et al (2004). Age, sexual behavior and human papillomavirus infection in oral cavity and oropharyngeal cancers. Int J Cancer, 108, 766-72. https://doi.org/10.1002/ijc.11633
  14. Sturgis EM, Ang KK (2011). The epidemic of HPV-associated oropharyngeal cancer is here: is it time to change our treatment paradigms? J Natl Compr Canc Netw, 9, 665-73.
  15. Nasman A, Attner P, Hammarstedt L, et al (2009). Incidence of human papillomavirus (HPV) positive tonsillar carcinoma in Stockholm, Sweden: an epidemic of viral-induced carcinoma? Int J Cancer, 125, 362-6. https://doi.org/10.1002/ijc.24339

Cited by

  1. Lack of Association between High-risk Human Papillomaviruses and Oral Squamous Cell Carcinoma in Young Japanese Patients vol.15, pp.10, 2014, https://doi.org/10.7314/APJCP.2014.15.10.4135
  2. Significance of p16 Positive Expression in Oropharyngeal Cancers vol.15, pp.23, 2015, https://doi.org/10.7314/APJCP.2014.15.23.10289
  3. Patients' preferences concerning follow‐up after curative head and neck cancer treatment: A cross‐sectional pilot study pp.1097-0347, 2019, https://doi.org/10.1002/hed.25686