- Volume 14 Issue 10
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Comparison of Population Based Cancer Incidence Rates among Circassians, Chechans and Arabs in Jordan (1996-2005)
- Fathallah, Raja Mohd-Talal (Center for Diabetes, Genetics and Endocrinology) ;
- Dajani, Rana (Department of Biology and Biotechnology, Faculty of Science Hashemite University)
- Published : 2013.10.30
Background: Cancer is a complex disease caused by multiple factors, both genetic and environmental. It is a major health concern worldwide, in the Middle East and in Jordan specifically and the fourth most common killer in the Middle East. Hypothesis: The relative genetic homogeneity of the Circassian and Chechan populations in Jordan results in incidences of cancer that differ from the general Jordanian population, who are mostly Arabs. Materials and Methods: National Cancer Registry data were obtained for the years 1996-2005 The Chechen and Circassian cancer cases were identified and cancer registry data were divided into three populations. Crude rates were calculated based on the number of cancer cases and estimated populations. Results: Breast cancer is the most common cancer type constituting about one third of female cancers in all three populations. Higher crude rates are observed in the Circassian and Chechen populations than in the Arab Jordanian population. The rate ratios (95%CI) in Circassians and Chechens with respect to the Arab Jordanian population are 2.1 (1.48, 2.72) and 1.81 (1.16, 2.85), respectively. Lung cancer is the most common cancer in male Arab Jordanians and Chechens with crude rates of 4.2 and 8.0 per 100,000 respectively. The male to female ratio in these two populations in respective order are 5:1 and 7:1. The lung cancer crude rate in Circassians is 6.5 per 100,000 with a male to female ratio of only 1.6:1. The colorectal cancer crude rates in Arab Jordanians and Chechens are similar at 6.2 and 6.0 per 100,000, respectively, while that in Circassians is twice as high. Conclusions: Considerable ethnic variation exists for cancer incidence rates in Jordan. The included inbred and selected populations offer an ideal situation for investigating genetic factors involved in various cancer types.
- Dajani R, Khader YS, Fatahallah R, et al (2012). Diabetes mellitus in genetically isolated populations in Jordan: prevalence, awareness, glycemic control, and associated factors. J Diabetes Complicat, 26, 175-80. https://doi.org/10.1016/j.jdiacomp.2012.03.009
- Ajlouni K, Khader YS, Batieha A, et al (2008). An increase in prevalence of diabetes mellitus in Jordan over 10 years. J Diabetes Complicat, 22, 317-24. https://doi.org/10.1016/j.jdiacomp.2007.01.004
- Al-Tarawneh M, Khatib S, Arqub K (2010). Cancer incidence in Jordan, 1996-2005. Eastern Mediterranean health journal=La revue de sante de la Mediterranee orientale=al-Majallah al-sihhiyah li-sharq al-mutawassit, 16, 837-45.
- Barbujani G, Nasidze IS, Whitehead GN (1994). Genetic diversity in the Caucasus. Hum Biol, 66, 639-68.
- Bulayeva KB (2006). Overview of genetic-epidemiological studies in ethnically and demographically diverse isolates of dagestan, Northern Caucasus, Russia. Croat Med J, 47, 641-8.
- Curado MP, Shin HR, Storm H, et al (2007). Cancer Incidence in five continents. IARC Scientific Publicatioins, 9.
- Dajani R, Khader YS, Hakooz N, et al (2013). Metabolic syndrome between two ethnic minority groups (Circassians and Chechens) and the original inhabitants of Jordan. Endocrine, 43, 112-9. https://doi.org/10.1007/s12020-012-9723-y
- Ferlay J, Shin HR, Bray F, et al (2010). Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. International journal of cancer. Int J Cancer, 127, 2893-917. https://doi.org/10.1002/ijc.25516
- Freedman LS, Edwards BK, Ries LAG, et al (2006). Cancer incidence in four member countries (Cyprus, Egypt, Israel and Jordan) of the Middle East Conortium (MECC) compared with US SEER. (MECC Monograph) Bethesda, MAryland, NAtional Cancer Insitute (NIH Publication No. 06-5873).
- Hawk ET, Levin B (2005). Colorectal cancer prevention. Journal of clinical oncology: official journal of the American Society of Clinical Oncology, 23, 378-91. https://doi.org/10.1200/JCO.2005.08.097
- Ismail SI, Soubani M, Nimri JM, et al (2013). Cancer incidence in jordan from 1996-2009: a comprehensive study. Asian Pac J Cancer Prev, 14, 3527-34. https://doi.org/10.7314/APJCP.2013.14.6.3527
- Kailani W (2002). Chechens in the Middle East: Between Original and Host Cultures. Caspian Studies Program.
- Mahasneh AA, Abdel-Hafiz SS (2004). Polymorphism of p53 gene in Jordanian population and possible associations with breast cancer and lung adenocarcinoma. Saudi Med J, 25, 1568-73.
- Ministry of Health. 2008. Jordan National Cancer Registry, Jordan.
- Nasidze I, Ling EY, Quinque D, et al (2004). Mitochondrial DNA and Y-chromosome variation in the caucasus. Ann Hum Genet, 68, 205-21. https://doi.org/10.1046/j.1529-8817.2004.00092.x
- Rastogi T, Hildesheim A, Sinha R (2004). Opportunities for cancer epidemiology in developing countries. Nat Rev Cancer, 4, 909-17. https://doi.org/10.1038/nrc1475
- Sener SF, Grey N (2005). The global burden of cancer. J Surg Oncol, 92, 1-3. https://doi.org/10.1002/jso.20335
- Yang YX, Hennessy S, Lewis JD (2005). Type 2 diabetes mellitus and the risk of colorectal cancer. J Am Gastroenterol Assoc, 3, 587-94.
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