- Volume 14 Issue 10
DOI QR Code
Pin1 Promoter rs2233678 and rs2233679 Polymorphisms in Cancer: A Meta-analysis
- Zhu, Yan-Mei (Tumor Etiology and Screening Department of Cancer Institute and General Surgery, the First Affiliated Hospital of China Medical University, the Key Laboratory of Cancer Etiology and Prevention (China Medical University), Liaoning Provincial Education Department) ;
- Liu, Jing-Wei (Tumor Etiology and Screening Department of Cancer Institute and General Surgery, the First Affiliated Hospital of China Medical University, the Key Laboratory of Cancer Etiology and Prevention (China Medical University), Liaoning Provincial Education Department) ;
- Xu, Qian (Tumor Etiology and Screening Department of Cancer Institute and General Surgery, the First Affiliated Hospital of China Medical University, the Key Laboratory of Cancer Etiology and Prevention (China Medical University), Liaoning Provincial Education Department) ;
- Yuan, Yuan (Tumor Etiology and Screening Department of Cancer Institute and General Surgery, the First Affiliated Hospital of China Medical University, the Key Laboratory of Cancer Etiology and Prevention (China Medical University), Liaoning Provincial Education Department)
- Published : 2013.10.30
PIN1 is one member of the parvulin PPIase family. By controlling Pro-directed phosphorylation, PIN1 plays an important role in cell transformation and oncogenesis. There are many polymorphisms in the PIN1 gene, including rs2233678 and rs2233679 affecting the PIN1 promoter. Recently, a number of case-control studies were conducted to investigate the association between PIN1 gene rs2233678 and rs2233679 polymorphism and cancer risk. However, published data are still conflicting. In this paper, we summarized data for 5,427 cancer cases and 5,469 controls from 9 studies and attempted to assess the susceptibility of PIN1 gene polymorphism to cancers by a synthetic meta-analysis. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated to assess the relationship. All analyses were performed using Stata software. Our results suggested that rs2233678 represented a protective factor in overall analysis (CC vs GG: OR= 0.697, 95%CI: 0.498-0.976; CG vs GG: OR=0.701, 95%CI: 0.572-0.858; Dominant model: OR= 0.707, 95%CI: 0.590-0.847; C allele vs G allele: OR=0.734, 95%CI: 0.623-0.867) and especially for squamous cell carcinoma of the head and neck, lung cancer and breast cancer in Asians and Caucasians. The rs2233679 polymorphism was significantly associated with decreased cancer risk in overall analysis (CT vs CC: OR=0.893, 95%CI=0.812-0.981; Dominant model: OR=0.893, 95%CI=0.816-0.976; T allele vs C allele; OR=0.947, 95%CI=0.896-1.000) and especially in Asians. In conclusion, our meta-analysis suggested that -842G>C (rs2233678) and -667C>T (rs2233679) may contribute to genetic susceptibility for cancer risks. Further prospective research with larger numbers of worldwide participants is warranted to draw comprehensive and firm conclusions.
PIN1;single nucleotide polymorphism;cancer;susceptibility;meta-analysis
- Carpenter RW, Tomko RL, Trull TJ, Boomsma DI. (2013). Gene-environment studies and borderline personality disorder: a review. Curr Psychiatry Rep, 15, 336. https://doi.org/10.1007/s11920-012-0336-1
- Ayala G, Wang D, Wulf G, et al (2003). The prolyl isomerase Pin1 is a novel prognostic marker in human prostate cancer. Cancer Res, 63, 6244-51.
- Begg CB, Mazumdar M (1994). Operating characteristics of a rank correlation test for publication bias. Biometrics, 50, 1088-101. https://doi.org/10.2307/2533446
- Cao WP, Tang HL, Lin P (2012). Association between polymorphisms in prolyl isomerase Pin1 and risk for laryngeal squamous cell carcinoma. Jiangsu Med, 38, 1067-670.
- Chung CC, Chanock SJ (2011). Current status of genome-wide association studies in cancer. Hum Genet, 130, 59-78. https://doi.org/10.1007/s00439-011-1030-9
- DeYoung CG, Clark R (2012). The gene in its natural habitat: the importance of gene-trait interactions. Dev Psychopathol, 24, 1307-18. https://doi.org/10.1017/S0954579412000727
- Dick, DM (2011). Gene-environment interaction in psychological traits and disorders. Annu Rev Clin Psychol, 7, 383-409. https://doi.org/10.1146/annurev-clinpsy-032210-104518
- Egger M, Davey Smith G, Schneider M, Minder C (1997). Bias in meta-analysis detected by a simple, graphical test. BMJ, 315, 629-34. https://doi.org/10.1136/bmj.315.7109.629
- Euhus DM, Robinson L (2013). Genetic predisposition syndromes and their management. Surg Clin North Am, 93, 341-62. https://doi.org/10.1016/j.suc.2013.01.005
- Fukuchi M, Fukai Y, Kimura H, et al (2006). Prolyl isomerase Pin1 expression predicts prognosis in patients with esophageal squamous cell carcinoma and correlates with cyclinD1 expression. Int J Oncol, 29, 329-34.
- Gao LB, Pan XM, Sun H, et al (2010). The association between ATM D1853N polymorphism and breast cancer susceptibility: a meta-analysis. J Exp Clin Cancer Res, 29, 117. https://doi.org/10.1186/1756-9966-29-117
- Liou YC, Zhou XZ, Lu KP (2011). Prolyl isomerase Pin1 as a molecular switch to determine the fate of phosphoproteins. Trends Biochem Sci, 36, 501-14. https://doi.org/10.1016/j.tibs.2011.07.001
- Han CH, Lu J, Wei Q, et al (2010). The functional promoter polymorphism (-842G>C) in the PIN1 gene is associated with decreased risk of breast cancer in non-Hispanic white women 55 years and younger. Breast Cancer Res Treat, 122, 243-9. https://doi.org/10.1007/s10549-009-0682-9
- He J, Zhou F, Shao K, et al (2007). Overexpression of Pin1 in non-small cell lung cancer (NSCLC) and its correlation with lymph node metastases. Lung Cancer, 56, 51-8. https://doi.org/10.1016/j.lungcan.2006.11.024
- Higgins JP, Thompson SG, Deeks JJ, Altman DG (2003). Measuring inconsistency in meta-analyses. BMJ, 327, 557-60. https://doi.org/10.1136/bmj.327.7414.557
- Lu J, Hu Z, Wei S, et al (2009). A novel functional variant (-842G>C) in the PIN1 promoter contributes to decreased risk of squamous cell carcinoma of the head and neck by diminishing the promoter activity. Carcinogenesis, 30, 1717-21. https://doi.org/10.1093/carcin/bgp171
- Lu J, Yang L, Zhao H, et al (2011). The polymorphism and haplotypes of PIN1 gene are associated with the risk of lung cancer in Southern and Eastern Chinese populations. Hum Mutat, 32, 1299-308. https://doi.org/10.1002/humu.21574
- Lu KP, Zhou XZ (2007). The prolyl isomerase PIN1: a pivotal new twist in phosphorylation signalling and disease. Nat Rev Mol Cell Biol, 8, 904-16. https://doi.org/10.1038/nrm2261
- Lu Y, Huang GL, Pu XX, et al (2013). Association between PIN1 promoter polymorphisms and risk of nasopharyngeal carcinoma. Mol Biol Rep, 40, 3777-82. https://doi.org/10.1007/s11033-012-2454-6
- Miyashita H, Mori S, Motegi K, et al (2003). Pin1 is overexpressed in oral squamous cell carcinoma and its levels correlate with cyclin D1 overexpression. Oncol Rep, 10, 455-61.
- Ramsberg J, Asseburg C, Henriksson M (2012). Effectiveness and cost-effectiveness of antidepressants in primary care: a multiple treatment comparison meta-analysis and cost-effectiveness model. PLoS One, 7, e42003. https://doi.org/10.1371/journal.pone.0042003
- Molina JD, Lopez-Munoz F, Stein DJ, et al (2009). Borderline personality disorder: a review and reformulation from evolutionary theory. Med Hypotheses, 73, 382-6. https://doi.org/10.1016/j.mehy.2009.03.024
- Naidu R, Har YC, Taib NA (2011). Analysis of peptidyl-propyl-cis/trans isomerase 1 (PIN1) gene -842(G > C) and -667(T> C) polymorphic variants in relation to breast cancer risk and clinico-pathological parameters. Scand J Clin Lab Invest, 71, 500-6. https://doi.org/10.3109/00365513.2011.590223
- Perez-Losada J, Castellanos-Martin A, Mao JH (2011). Cancer evolution and individual susceptibility. Integr Biol (Camb), 3, 316-28. https://doi.org/10.1039/c0ib00094a
- Segat L, Milanese M, Crovella S (2007). Pin1 promoter polymorphisms in hepatocellular carcinoma patients. Gastroenterology, 132, 2618-9; author reply 9-20. https://doi.org/10.1053/j.gastro.2007.04.037
- Theuerkorn M, Fischer G, Schiene-Fischer C (2011). Prolyl cis/trans isomerase signalling pathways in cancer. Curr Opin Pharmacol, 11, 281-7. https://doi.org/10.1016/j.coph.2011.03.007
- Xue H, Lin B, Ni P, et al (2010). Interleukin-1B and interleukin-1 RN polymorphisms and gastric carcinoma risk: a meta-analysis. J Gastroenterol Hepatol, 25, 1604-17. https://doi.org/10.1111/j.1440-1746.2010.06428.x
- You Y, Deng J, Zheng J, et al (2013). Functional polymorphisms in PIN1 promoter and esophageal carcinoma susceptibility in Chinese population. Mol Biol Rep, 40, 829-38. https://doi.org/10.1007/s11033-012-2122-x
- Zhao H (2009). Association between polymorphisms in prolyl isomerase Pin1 promoter and risk for lung cancer. . Guangzhou Medical University: [D] Guangzhou.
- Four Polymorphisms in the Cytochrome P450 1A2 (CYP1A2) Gene and Lung Cancer Risk: a Meta-analysis vol.15, pp.14, 2014, https://doi.org/10.7314/APJCP.2014.15.14.5673