DOI QR코드

DOI QR Code

Association Between Genetic Polymorphism of XRCC1 Gene and Risk of Glioma in а Chinese Population

  • Wang, Ying-Xin (Department of Neurology, The First Affiliated Hospital of Dalian Medical University) ;
  • Fan, Kai (Department of anatomy, Dalian Medical University) ;
  • Tao, Ding-Bo (Department of Neurology, The First Affiliated Hospital of Dalian Medical University) ;
  • Dong, Xiang (Department of Neurology, The First Affiliated Hospital of Dalian Medical University)
  • Published : 2013.10.30

Abstract

Background: Gliomas are the most common type of primary brain tumor in adults, and the X-ray repair complementing group 1 gene (XRCC1) is an important candidate gene influencing its risk. The objective of this study was to detect the influence of XRCC1 genetic polymorphisms on glioma risk. Materials and Methods: A total of 629 glioma patients and 641 cancer-free subjects were enrolled in this case-control study. The genotypes of the c.1471G>A genetic polymorphism were determined by created restriction site-polymerase chain reaction (CRS-PCR) and DNA sequencing methods. The influence of the XRCC1 genetic polymorphism on glioma risk was evaluated by association analysis. Results: Our data indicated that the alleles/genotype of this genetic variant was statistically associated with glioma risk. The AA genotype was statistically associated with the increased risk of glioma compared to the GG wild genotype (odds ratios (OR) = 1.89, 95% CI 1.25-2.87, P = 0.003). The allele-A may contribute to increased the susceptibility to glioma (OR = 1.23, 95% CI 1.04-1.46, P = 0.017). Conclusions: These preliminary findings indicate that the c.1471G>A genetic polymorphism of XRCC1 has the potential to influence glioma susceptibility, and might be used as molecular marker for assessing glioma risk.

Keywords

Glioma;XRCC1 gene;genetic polymorphism;molecular marker;risk factors

References

  1. Jacobs DI, Bracken MB (2012). Association between XRCC1 polymorphism 399 G->A and glioma among Caucasians: a systematic review and meta-analysis. BMC Med Genet, 13, 97.
  2. Felini MJ, Olshan AF, Schroeder JC, et al (2007). DNA repair polymorphisms XRCC1 and MGMT and risk of adult gliomas. Neuroepidemiology, 29, 55-8. https://doi.org/10.1159/000108919
  3. Haliassos A, Chomel JC, Tesson L, et al (1989). Modification of enzymatically amplified DNA for the detection of point mutations. Nucleic Acids Res, 17, 3606. https://doi.org/10.1093/nar/17.9.3606
  4. Hu XB, Feng Z, Fan YC, et al (2011). Polymorphisms in DNA repair gene XRCC1 and increased genetic susceptibility to glioma. Asian Pac J Cancer Prev, 12, 2981-4.
  5. Jiang L, Fang X, Bao Y, et al (2013). Association between the XRCC1 polymorphisms and glioma risk: a meta-analysis of case-control studies. PLoS One, 8, e55597. https://doi.org/10.1371/journal.pone.0055597
  6. Kiuru A, Lindholm C, Heinavaara S, et al (2008). XRCC1 and XRCC3 variants and risk of glioma and meningioma. J Neurooncol, 88, 135-42. https://doi.org/10.1007/s11060-008-9556-y
  7. Melin B (2011). Genetic causes of glioma: new leads in the labyrinth. Curr Opin Oncol, 23, 643-7. https://doi.org/10.1097/CCO.0b013e32834a6f61
  8. Liu HB, Peng YP, Dou CW, et al (2012). Comprehensive study on associations between nine SNPs and glioma risk. Asian Pac J Cancer Prev, 13, 4905-8. https://doi.org/10.7314/APJCP.2012.13.10.4905
  9. Liu Y, Scheurer ME, El-Zein R, et al (2009). Association and interactions between DNA repair gene polymorphisms and adult glioma. Cancer Epidemiol Biomarkers Prev, 18, 204-14. https://doi.org/10.1158/1055-9965.EPI-08-0632
  10. Luo KQ, Mu SQ, Wu ZX, et al (2013). Polymorphisms in DNA repair genes and risk of glioma and meningioma. Asian Pac J Cancer Prev, 14, 449-52. https://doi.org/10.7314/APJCP.2013.14.1.449
  11. Mutamba JT, Svilar D, Prasongtanakij S, et al (2011). XRCC1 and base excision repair balance in response to nitric oxide. DNA Repair (Amst), 10, 1282-93. https://doi.org/10.1016/j.dnarep.2011.10.008
  12. Pan WR, Li G, Guan JH (2013). Polymorphisms in DNA repair genes and susceptibility to glioma in a chinese population. Int J Mol Sci, 14, 3314-24. https://doi.org/10.3390/ijms14023314
  13. Rajaraman P, Hutchinson A, Wichner S, et al (2010). DNA repair gene polymorphisms and risk of adult meningioma, glioma, and acoustic neuroma. Neuro Oncol, 12, 37-48. https://doi.org/10.1093/neuonc/nop012
  14. Ricard D, Idbaih A, Ducray F, et al (2012). Primary brain tumours in adults. Lancet, 379, 1984-96. https://doi.org/10.1016/S0140-6736(11)61346-9
  15. Sun JY, Zhang CY, Zhang ZJ, et al (2012). Association between XRCC1 gene polymorphisms and risk of glioma development: a meta-analysis. Asian Pac J Cancer Prev, 13, 4783-8. https://doi.org/10.7314/APJCP.2012.13.9.4783
  16. Tudek B (2007). Base excision repair modulation as a risk factor for human cancers. Mol Aspects Med, 28, 258-75. https://doi.org/10.1016/j.mam.2007.05.003
  17. Wen PY, Kesari S (2008). Malignant gliomas in adults. N Engl J Med, 359, 492-507. https://doi.org/10.1056/NEJMra0708126
  18. Wang D, Hu Y, Gong H, et al (2012). Genetic polymorphisms in the DNA repair gene XRCC1 and susceptibility to glioma in a Han population in northeastern China: a case-control study. Gene, 509, 223-7. https://doi.org/10.1016/j.gene.2012.08.023
  19. Wang LE, Bondy ML, Shen H, et al (2004). Polymorphisms of DNA repair genes and risk of glioma. Cancer Res, 64, 5560-3. https://doi.org/10.1158/0008-5472.CAN-03-2181
  20. Wei X, Chen D, Lv T (2013). A functional polymorphism in XRCC1 is associated with glioma risk: evidence from a meta-analysis. Mol Biol Rep, 40, 567-72. https://doi.org/10.1007/s11033-012-2093-y
  21. Yosunkaya E, Kucukyuruk B, Onaran I, et al (2010). Glioma risk associates with polymorphisms of DNA repair genes, XRCC1 and PARP1. Br J Neurosurg, 24, 561-5. https://doi.org/10.3109/02688697.2010.489655
  22. Yuan ZR, Li J, Li JY, et al (2013). SNPs identification and its correlation analysis with milk somatic cell score in bovine MBL1 gene. Mol Biol Rep, 40, 7-12. https://doi.org/10.1007/s11033-012-1934-z
  23. Yuan ZR, Li JY, Li J, et al (2012). Investigation on BRCA1 SNPs and its effects on mastitis in Chinese commercial cattle. Gene, 505, 190-4. https://doi.org/10.1016/j.gene.2012.05.010
  24. Yuan ZR, Li JY, Li J, et al (2013). Effects of DGAT1 gene on meat and carcass fatness quality in Chinese commercial cattle. Mol Biol Rep, 40, 1947-54. https://doi.org/10.1007/s11033-012-2251-2
  25. Zhang L, Wang Y, Qiu Z, et al (2012). The XRCC1 Arg194Trp polymorphism is not a risk factor for glioma: A meta-analysis involving 1,440 cases and 2,562 controls. Exp Ther Med, 4, 1057-62.
  26. Zhao CJ, Li N, Deng XM (2003). The establishment of method for identifying SNP genotype by CRS-PCR. Yi Chuan, 25, 327-9.
  27. Zhou LQ, Ma Z, Shi XF, et al (2011). Polymorphisms of DNA repair gene XRCC1 and risk of glioma: a case-control study in Southern China. Asian Pac J Cancer Prev, 12, 2547-50.

Cited by

  1. Application of Computed Tomography for Differential Diagnosis of Glioma Stoke and Simple Cerebral Hemorrhage vol.15, pp.8, 2014, https://doi.org/10.7314/APJCP.2014.15.8.3425