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Roles of mTOR and p-mTOR in Gastrointestinal Stromal Tumors

  • Li, Jun-Chuan (Department of Pathology, The First Affiliated Hospital of Yangtze University) ;
  • Zhu, Hong-Yu (Department of Pathology, The First Affiliated Hospital of Yangtze University) ;
  • Chen, Ting-Xuan (Department of Pathology, The First Affiliated Hospital of Yangtze University) ;
  • Zou, Lan-Ying (Department of Pathology, The First Affiliated Hospital of Yangtze University) ;
  • Wang, Xiao-Yan (Department of Pathology, The First Affiliated Hospital of Yangtze University) ;
  • Zhao, Hui-Chuan (Department of Pathology, The First Affiliated Hospital of Yangtze University) ;
  • Xu, Jun (Department of Pathology, The First Affiliated Hospital of Yangtze University)
  • Published : 2013.10.30

Abstract

Objective: This study aimed to examine the relationship between expression of mammal target of rapamycin (mTOR) and phosphorylation of mTOR (p-mTOR) protein in the PI3K/Akt/mTOR signaling pathways in gastrointestinal stromal tumors and relatiuonships with clinical factors. Methods: Immunohistochemistry was used to detect the expression of the associated proteins mTOR, p-mTOR, and phosphorylation of the tumor suppressor genes PTEN, P27, VEGF, and EGFR in 40 cases of gastrointestinal stromal tumors, with division into a very low and low risk group as well as a moderate and high risk group. Results: The positive rate of mTOR and p-mTOR was significantly increased in the moderate and high risk group compared with the very low and low risk group. The difference was statistically significant (P<0.05). When grouped according to size, the positive mTOR expression rate exhibited a statistical difference (P<0.05), which was significantly increased in the group of tumors larger than 5 cm. The difference in the positive mTOR and p-mTOR expression rate exhibit no statistical significance among the PTEN, P27, VEGF, and EGFR expression subgroups (P>0.05). Conclusion: The different expressions of mTOR and p-mTOR in the signal transduction pathway of gastrointestinal stromal tumor in the different degree-of-risk groups suggested that the mTOR and p-mTOR of the signal transduction pathway serve an important function in the occurrence and development of gastrointestinal stromal tumors.

Keywords

mTOR;p-mTOR;gastrointestinal stromal tumor;signal transduction pathways

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