- Volume 14 Issue 10
DOI QR Code
Effects of Garlic Oil on Pancreatic Cancer Cells
- Lan, X.Y. (Department of Pharmacology, Dalian Medical University) ;
- Sun, H.Y. (Department of Pharmacology, Dalian Medical University) ;
- Liu, J.J. (Department of Pharmacology, Dalian Medical University) ;
- Lin, Y. (Department of Pharmacology, Dalian Medical University) ;
- Zhu, Z.Y. (Department of Pharmacology, Dalian Medical University) ;
- Han, X. (Department of Pharmacology, Dalian Medical University) ;
- Sun, X. (Department of Pharmacology, Dalian Medical University) ;
- Li, X.R. (Department of Pharmacology, Dalian Medical University) ;
- Zhang, H.C. (Department of Pharmacology, Dalian Medical University) ;
- Tang, Z.Y. (Department of Pharmacology, Dalian Medical University)
- Published : 2013.10.30
Background: To investigate the preventive and therapeutic potential of garlic oil on human pancreatic carcinoma cells. Methods: The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) assay was performed to study the effects of garlic oil on three human pancreatic cancer cell lines, AsPC-1, Mia PaCa-2 and PANC-1. Cell cycle progression and apoptosis were detected by flow cytometry (FCM), staining with PI and annexin V-fluorescein isothiocyanate (FITC)/propidium iodide (PI), respectively. Morphologic changes of pancreatic cancer cells were observed under transmission electron microscopy (TEM) after treatment with garlic oil at low inhibitory concentrations (
Garlic oil;pancreatic carcinoma;AsPC-1 cells;proliferation;apoptosis
Supported by : Natural Science Foundation of China
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