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Role of DNA Repair-related Gene Polymorphisms in Susceptibility to Risk of Prostate Cancer

  • Yang, Bo (Department of Urology Surgery, Shanghai Pudong New Area Zhoupu Hospital) ;
  • Chen, Wei-Hua (Department of Urology Surgery, Shanghai East Hospital Affiliated to Tongji University) ;
  • Wen, Xiao-Fei (Department of Urology Surgery, Shanghai East Hospital Affiliated to Tongji University) ;
  • Liu, Hui (Department of Urology Surgery, Shanghai Pudong New Area Zhoupu Hospital) ;
  • Liu, Feng (Department of Urology Surgery, Shanghai Pudong New Area Zhoupu Hospital)
  • Published : 2013.10.30

Abstract

Aim: We assessed the association between genetic variants of XPG, XPA, XPD, CSB, XPC and CCNH in the nucleotide excision repair (NER) pathway and risk of prostate cancer. Methods: We genotyped the XPG, XPA, XPD, CSB, XPC and CCNH polymorphisms by a 384-well plate format on the MassARRAY(R) platform. Multivariate logistical regression analysis was used to assess the associations between the six gene polymorphisms and risk of prostate cancer. Results: Individuals carrying the XPG rs229614 TT (OR=2.01, 95%CI=1.35-3.27) genotype and T allele (OR=1.73, 95%CI=1.37-2.57) were moderately significantly associated with a higher risk of prostate cancer. Subjects with XPD rs13181 G allele had a marginally increased risk of prostate cancer, with adjusted OR(95%CI) of 1.53 (1.04-2.37). Moreover, individuals carrying with CSB rs2228526 GG genotype (OR=2.05, 95% CI=1.23-3.52) and G allele (OR=1.56, 95%CI=1.17-2.05) were associated with a higher increased risk of prostate cancer. The combination genotype of XPG rs2296147 T and CSB rs2228526 G allele had accumulative effect on the risk of this cancer, with an OR (95% CI) of 2.23(1.37-3.59). Conclusions: Our study indicates that XPG rs2296147 and CSB rs2228526 polymorphisms are significantly associated with increased risk of prostate cancer, and that combination of XPG rs2296147 T allele and CSB rs2228526 G allele is strongly associated with an increased risk.

Keywords

XPG;CSB;DNA repair;related genes;prostate cancer;polymorphism

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