Association of a VDR Gene Polymorphism with Risk of Colorectal Cancer in Kashmir

  • Rasool, Sabha (Department of Biochemistry, University of Kashmir) ;
  • Kadla, Showkat Ahmad (Division of Gastroeneterology, Department of Medicine, Government Medical College Srinagar) ;
  • Khan, Tanzeela (Department of Biochemistry, University of Kashmir) ;
  • Qazi, Falak (Department of Biochemistry, University of Kashmir) ;
  • Shah, Nisar Ahmad (Division of Gastroeneterology, Department of Medicine, Government Medical College Srinagar) ;
  • Basu, Javed (Division of Gastroeneterology, Department of Medicine, Government Medical College Srinagar) ;
  • Khan, Bilal Ahmad (Division of Gastroeneterology, Department of Medicine, Government Medical College Srinagar) ;
  • Ahktar, Qulsum (Department of Biochemistry, University of Kashmir) ;
  • Sameer, Aga Syed (Department of Clinical Biochemistry, Government Medical College) ;
  • Ganai, Bashir Ahmad (Department of Biochemistry, University of Kashmir)
  • Published : 2013.10.30


Roles of the vitamin D receptor in etiology of cancers, including colorectal cancer, have been repeatedly stressed in different parts of the world. A case control study aimed to evaluate the relationship between the two was therefore initiated in Kashmir, known both for its increasing incidence of gastrointestinal cancers and deficiency of micro-nutrients especially vitamin D. The study included a total of 617 subjects (312 colorectal cancer cases and 305 controls), with sampling carried out over a period of 5 years. DNA samples from the blood of the subjects were analyzed for start codon Fok I VDR polymorphism. We obtained a 1.3 fold increased risk among individuals homozygous for f variants as compared to subjects homozygous for F allele (odds ratio OR 1.3, 95%CI, 0.861-1.65). Our study also showed statistically significant results when dwelling and tumor location characteristics were stratified with Fok I polymorphism, all of which suggests a possible role of Fok I polymorphism in the etiology of CRC in Kashmir.


VDR Fok I polymorphism;colorectal cancer;cancer epidemiology


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