DOI QR코드

DOI QR Code

Association of a VDR Gene Polymorphism with Risk of Colorectal Cancer in Kashmir

  • Rasool, Sabha (Department of Biochemistry, University of Kashmir) ;
  • Kadla, Showkat Ahmad (Division of Gastroeneterology, Department of Medicine, Government Medical College Srinagar) ;
  • Khan, Tanzeela (Department of Biochemistry, University of Kashmir) ;
  • Qazi, Falak (Department of Biochemistry, University of Kashmir) ;
  • Shah, Nisar Ahmad (Division of Gastroeneterology, Department of Medicine, Government Medical College Srinagar) ;
  • Basu, Javed (Division of Gastroeneterology, Department of Medicine, Government Medical College Srinagar) ;
  • Khan, Bilal Ahmad (Division of Gastroeneterology, Department of Medicine, Government Medical College Srinagar) ;
  • Ahktar, Qulsum (Department of Biochemistry, University of Kashmir) ;
  • Sameer, Aga Syed (Department of Clinical Biochemistry, Government Medical College) ;
  • Ganai, Bashir Ahmad (Department of Biochemistry, University of Kashmir)
  • Published : 2013.10.30

Abstract

Roles of the vitamin D receptor in etiology of cancers, including colorectal cancer, have been repeatedly stressed in different parts of the world. A case control study aimed to evaluate the relationship between the two was therefore initiated in Kashmir, known both for its increasing incidence of gastrointestinal cancers and deficiency of micro-nutrients especially vitamin D. The study included a total of 617 subjects (312 colorectal cancer cases and 305 controls), with sampling carried out over a period of 5 years. DNA samples from the blood of the subjects were analyzed for start codon Fok I VDR polymorphism. We obtained a 1.3 fold increased risk among individuals homozygous for f variants as compared to subjects homozygous for F allele (odds ratio OR 1.3, 95%CI, 0.861-1.65). Our study also showed statistically significant results when dwelling and tumor location characteristics were stratified with Fok I polymorphism, all of which suggests a possible role of Fok I polymorphism in the etiology of CRC in Kashmir.

Keywords

VDR Fok I polymorphism;colorectal cancer;cancer epidemiology

References

  1. Arai H, Miyamoto K, Taketani Y, et al (1997). A vitamin D receptor gene polymorphism in the translation initiation codon: effect on protein activity and relation to bone mineral density in Japanese women. J Bone Miner Res, 12, 915-21. https://doi.org/10.1359/jbmr.1997.12.6.915
  2. Belov L, Zhou J, Christopherson RI (2011). Cell surface markers in colorectal cancer prognosis. Int J Mol Sci, 12, 78-113.
  3. Borek C (2004). Dietary antioxidants and human cancer. Integr Cancer Ther, 3, 333-41. https://doi.org/10.1177/1534735404270578
  4. Bretherton-Watt D, Given-Wilson R, Mansi JL (2001). Vitamin D receptor gene polymorphisms are associated with breast cancer risk in a UK Caucasian population. Br J Cancer, 85, 171-5. https://doi.org/10.1054/bjoc.2001.1864
  5. Chakravarti AK (1974). Regional preferences for food: some aspects of food patterns in India. Can Geogr, 18, 395-410. https://doi.org/10.1111/j.1541-0064.1974.tb00212.x
  6. Chiu KC, Chuang LM, Yoon C (2001). The vitamin D receptor polymorphism in the translation initiation codon is a risk factor for insulin resistance in glucose tolerant Caucasians. BMC Med Genet, 2, 2.
  7. Dar NA, Bhat GA, Shah IA, et al (2012). Hookah smoking, nass chewing and oesophageal cell carcinoma in Kashmir, India. Br J Cancer, 107, 1618-23. https://doi.org/10.1038/bjc.2012.449
  8. Chokkalingam AP, McGlynn KA, Gao YT, et al (2001). Vitamin D receptor gene polymorphisms, insulin-like growth factors and prostate cancer risk: a population-based case-control study in China. Cancer Res, 61, 4333-6.
  9. Correa-Cerro L, Berthon P, Haussler J (1999). Vitamin D receptor polymorphisms as markers in prostate cancer. Hum Genet, 105, 281-7. https://doi.org/10.1007/s004390051102
  10. Curran JE, Vaughan T, Lea RA, et al (1999). Association of a vitamin D receptor polymorphism with sporadic breast cancer development. Int J Cancer, 83, 723-26. https://doi.org/10.1002/(SICI)1097-0215(19991210)83:6<723::AID-IJC4>3.0.CO;2-3
  11. Feinberg AP, Vogelstein B (1987). Alterations in DNA methylation in human colon neoplasia. Semin Surg Oncol, 3, 149-51. https://doi.org/10.1002/ssu.2980030304
  12. Giovannucci E (2005). The epidemiology of vitamin D and cancer incidence and mortality: a review (United States). Cancer Causes Control, 16, 83-95. https://doi.org/10.1007/s10552-004-1661-4
  13. Gross C, Krishnan AV, Malloy PJ, et al (1998). The vitamin D receptor gene start codon polymorphism: a functional analysis of Fok I variants. J Bone Miner Res, 13, 1691-9. https://doi.org/10.1359/jbmr.1998.13.11.1691
  14. Haussler MR, Whitfield GK, Haussler CA, et al (1998). The nuclear vitamin D receptor: biological and molecular regulatory properties revealed. J Bone Miner Res, 13, 325-49. https://doi.org/10.1359/jbmr.1998.13.3.325
  15. Hubner RA, Muir KR, Liu JF, et al (2008). Dairy products, polymorphisms in the vitamin D receptor gene and colorectal adenoma recurrence. Int J Cancer, 123, 586-93. https://doi.org/10.1002/ijc.23536
  16. Hussain SMY, Thakur N, Salam I, et al (2011). Association of cyclin D1 gene polymorphisms with risk of esophageal squamous cell carcinoma in Kashmir Valley-a high risk area. Mol Carcinog, 50, 487-98. https://doi.org/10.1002/mc.20732
  17. Kadiyska T, Yakulov T, Kaneva R, et al (2007). Vitamin D and estrogen receptor gene polymorphisms and the risk of colorectal cancer in Bulgaria. Int J Colorectal Dis, 22, 395-400. https://doi.org/10.1007/s00384-006-0163-0
  18. Ingles SA, Garcia DG, Wang W, Nieters A (2000). Vitamin D receptor genotype and breast cancer in Latinas (United States). Cancer Causes Control, 11, 25-30. https://doi.org/10.1023/A:1008979417618
  19. Javid G, Zargar SA, Rather S, et al (2011). Incidence of colorectal cancer in Kashmir valley, India. Indian J Gastroenterol, 30, 7-11 https://doi.org/10.1007/s12664-010-0071-7
  20. Jurutka PW, Remus LS, Whitfield GK, et al (2000). The polymorphic N terminus in human vitamin D receptor isoforms influences transcriptional activity by modulating interaction with transcription factor IIB. Mol Endocrinol, 14, 401-20. https://doi.org/10.1210/mend.14.3.0435
  21. Kostner KIM, Denzer N, Muller CSL, et al (2009). The relevance of vitamin D receptor (VDR) gene polymorphisms for cancer: a review of the literature. Anticancer Res, 29, 3511-36.
  22. Kovacic P, Jacintho JD (2001). Mechanisms of carcinogenesis: focus on oxidative stress and electron transfer. Curr Med Chem, 8, 773-96. https://doi.org/10.2174/0929867013373084
  23. Lamprecht SA, Lipkin M (2001). Cellular mechanisms of calcium and vitamin D in the inhibition of colorectal carcinogenesis. Ann NY Acad Sci, 952, 73-87.
  24. Malecki MT, Frey J, Moczulski D, et al (2003). Vitamin D receptor gene polymorphisms and association with type 2 diabetes mellitus in a Polish population. Exp Clin Endocrinol Diabetes, 111, 505-9. https://doi.org/10.1055/s-2003-44711
  25. Malik MA, Zargar SA, Mittal B (2011a). Role of the metalloproteinase-7 (181A>G) polymorphism in gastric cancer susceptibility: a case control study in Kashmir Valley. Asian Pac J Cancer Prev, 12, 73-6.
  26. Miyamoto K, Kesterson RA, Yamamoto H, et al (1997). Structural organization of the human vitamin D receptor chromosomal gene and its promoter. Mol Endocrinol, 11, 1165-79. https://doi.org/10.1210/mend.11.8.9951
  27. Malik MA, Sharma K, Goel S, Zargar SA, Mittal B (2011b). Association of TP53 intron 3, 16 bp duplication polymorphism with esophageal and gastric cancer susceptibility in Kashmir Valley. Oncol Res, 19, 165-9. https://doi.org/10.3727/096504011X12935427587920
  28. Malik MA, Zargar SA, Mittal B (2011c). Role of NQO1 609C>T and NQO2-3423 G>A polymorphisms in susceptibility to gastric cancer in Kashmir Valley. DNA Cell Biol, 30, 297-303. https://doi.org/10.1089/dna.2010.1115
  29. McCullough ML, Bostick RM, Mayo TL (2009). Vitamin D gene pathway polymorphisms and risk of colorectal, breast, and prostate cancer. Annu Rev Nutr, 29, 111-32. https://doi.org/10.1146/annurev-nutr-080508-141248
  30. Murtaza I, Mushtaq D, Margoob MA, et al (2006). A study on p53 gene alterations in esophageal squamous cell carcinoma and their correlation to common dietary risk factors among population of the Kashmir valley. World J Gastroenterol, 12, 4033-7.
  31. Neyestani TR, Djazayerya A, Shab-Bidar S, et al (2013). Vitamin D receptor Fok I polymorphism modulates diabetic host response to vitamin D intake. Diabetes Care, 36, 550-6. https://doi.org/10.2337/dc12-0919
  32. Ochs-Balcom HM, Cicek MS, Thompson CL, et al (2008). Association of vitamin D receptor gene variants, adiposity and colon cancer. Carcinogenesis, 29, 1788-93. https://doi.org/10.1093/carcin/bgn166
  33. O'Connell, JB, Maggard MA, Ko CY (2004). Colon cancer survival rates with the new American joint committee on cancer sixth edition staging. J Natl Cancer Inst, 96, 1420-5. https://doi.org/10.1093/jnci/djh275
  34. Park K, Woo M, Nam J, Kim JC (2006). Start codon polymorphisms in the vitamin D receptor and colorectal cancer risk. Cancer Lett, 237, 199-206. https://doi.org/10.1016/j.canlet.2005.05.048
  35. Siddiqi M, Tricker AR, Preussmann R (1988). The occurrence of preformed N-nitroso compounds in the food samples from a high risk area of esophageal cancer in Kashmir, India. Cancer Lett, 39, 37-43. https://doi.org/10.1016/0304-3835(88)90038-9
  36. Rasool MT, Lone MM, Wani ML, et al (2012). Cancer in Kashmir, India: burden and pattern of disease. J Can Res Ther, 8, 243-6 https://doi.org/10.4103/0973-1482.98978
  37. Rasool S, Ganai BA, Kadla SA, et al (2011). The ECRG1 290Arg/Gln polymorphism is related to risk of esophageal squamous cell carcinoma in Kashmir. Asian Pac J Cancer Prev, 12, 265-9.
  38. Rasool S, Ganai BA, Sameer AS, Masood A (2012). Esophageal cancer: associated factors with special reference to the Kashmir Valley. Tumori, 98, 191-203.
  39. Slattery ML, Wolff RK, Herrick JS, Caan BJ, Potter JD (2007). IL6 genotypes and colo and rectal cancer. Cancer Causes Control, 18, 1095-105. https://doi.org/10.1007/s10552-007-9049-x
  40. Tajouri L, Ovcaric M, Curtain R, et al (2005). Variation in the vitamin D receptor gene is associated with multiple sclerosis in an Australian population. J Neurogenet, 19, 25-38. https://doi.org/10.1080/01677060590949692
  41. Timbo BB, Ross MP, McCarthy PV, Lin CT (2006). Dietary supplements in a national survey: prevalence of use and reports of adverse events. J Am Diet Assoc, 106, 1966-74. https://doi.org/10.1016/j.jada.2006.09.002
  42. Uitterlinden AG, Fang Y, Van Meurs JB, Pols HA, Van Leeuwen JP (2004). Genetics and biology of vitamin D receptor polymorphisms. Gene, 338, 143-56. https://doi.org/10.1016/j.gene.2004.05.014
  43. Whitfield GK, Remus LS, Jurutka PW, et al (2001). Functionally relevant polymorphisms in the human nuclear vitamin D receptor gene. Mol Cell Endocrinol, 177, 145-59. https://doi.org/10.1016/S0303-7207(01)00406-3
  44. Wong HL, Seow A, Arakawa K, et al (2003). Vitamin D receptor start codon polymorphism and colorectal cancer risk: effect modification by dietary calcium and fat in Singapore Chinese. Carcinogenesis, 24, 1091-5. https://doi.org/10.1093/carcin/bgg059

Cited by

  1. Vitamin D Receptor BsmI Polymorphism and Colorectal Cancer Risk: an Updated Analysis vol.15, pp.12, 2014, https://doi.org/10.7314/APJCP.2014.15.12.4801
  2. Association between Circulating Vitamin D, the Taq1 Vitamin D Receptor Gene Polymorphism and Colorectal Cancer Risk among Jordanians vol.15, pp.17, 2014, https://doi.org/10.7314/APJCP.2014.15.17.7337
  3. Genetic unraveling of colorectal cancer vol.35, pp.6, 2014, https://doi.org/10.1007/s13277-014-1713-7
  4. Associations between Vitamin D Receptor (VDR) Gene Polymorphisms and Colorectal Cancer Risk and Effect Modifications of Dietary Calcium and Vitamin D in a Japanese Population vol.16, pp.5, 2015, https://doi.org/10.7314/APJCP.2015.16.5.2019
  5. Associations of Probiotics with Vitamin D and Leptin Receptors and their Effects on Colon Cancer vol.16, pp.9, 2015, https://doi.org/10.7314/APJCP.2015.16.9.3621
  6. Association of Dietary Vitamin D and Calcium With Genetic Polymorphisms in Colorectal Neoplasia vol.20, pp.2, 2015, https://doi.org/10.15430/JCP.2015.20.2.97
  7. gene polymorphism with sex- and non-sex-associated cancers: A meta-analysis vol.39, pp.10, 2017, https://doi.org/10.1177/1010428317727164
  8. Positive correlation between vitamin D receptor gene FokI polymorphism and colorectal cancer susceptibility in South-Khorasan of Iran vol.119, pp.10, 2018, https://doi.org/10.1002/jcb.26826
  9. Vitamin D receptor FokI polymorphism and the risks of colorectal cancer, inflammatory bowel disease, and colorectal adenoma vol.8, pp.1, 2018, https://doi.org/10.1038/s41598-018-31244-5