DOI QR코드

DOI QR Code

Associations Between XRCC1 Arg399Gln, Arg194Trp, and Arg280His Polymorphisms and Risk of Differentiated Thyroid Carcinoma: A Meta-analysis

  • Du, Yang (Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Key Lab of Etiology and Epidemiology, Education Bureau of Hei Long Jiang Province & Ministry of Health) ;
  • Han, Li-Yuan (Department of Preventive Medicine, Medical School of Ningbo University) ;
  • Li, Dan-Dan (Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Key Lab of Etiology and Epidemiology, Education Bureau of Hei Long Jiang Province & Ministry of Health) ;
  • Liu, Hui (Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Key Lab of Etiology and Epidemiology, Education Bureau of Hei Long Jiang Province & Ministry of Health) ;
  • Gao, Yan-Hui (Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Key Lab of Etiology and Epidemiology, Education Bureau of Hei Long Jiang Province & Ministry of Health) ;
  • Sun, Dian-Jun (Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Key Lab of Etiology and Epidemiology, Education Bureau of Hei Long Jiang Province & Ministry of Health)
  • Published : 2013.09.30

Abstract

Background: Associations between Arg399Gln, Arg194Trp and Arg280His polymorphisms of the XRCC1 gene and risk of differentiated thyroid carcinoma (DTC) have been widely studied but the findings are contradictory. Methods: We performed a meta-analysis in the present study using STATA 11.0 software to clarify any associations. Electronic literature databases and reference lists of relevant articles revealed a total of 10, 6 and 6 published studies for the Arg399Gln, Arg194Trp and Arg280His polymorphisms, respectively. Results: No significant associations were observed between Arg399Gln and DTC risk in all genetic models within the overall and subgroup meta-analyses, while the Trp/Trp vs Arg/Arg and recessive model of the Arg194Trp polymorphism was associated with DTC susceptibility, and the dominant model of Arg280His polymorphism contributed to DTC susceptibility in Caucasians. Conclusions: Our meta-analysis suggests that XRCC1 Arg194Trp may be a risk factor for DTC development.

Keywords

XRCC1;Arg399Gln;Arg194Trp;Arg280His;differentiated thyroid carcinoma;meta-analysis

References

  1. Akulevich NM, Saenko VA, Rogounovitch TI, et al (2009). Polymorphisms of DNA damage response genes in radiationrelated and sporadic papillary thyroid carcinoma. Endocr Relat Cancer, 16, 491-503. https://doi.org/10.1677/ERC-08-0336
  2. Alberg AJ, Jorgensen TJ, Ruczinski I, et al (2013). DNA repair gene variants in relation to overall cancer risk: a populationbased study. Carcinogenesis, 34, 86-92. https://doi.org/10.1093/carcin/bgs304
  3. Aschebrook-Kilfoy B, Ward MH, Sabra MM, et al (2011). Thyroid cancer incidence patterns in the United States by histologic type, 1992–2006. Thyroid, 21, 125-34. https://doi.org/10.1089/thy.2010.0021
  4. Bonora E, Tallini G, Romeo G (2010). Genetic predisposition to familial nonmedullary thyroid cancer: an update of molecular findings and state-of-the-art studies. J Oncol, 2010, 385206.
  5. Chiang FY, Wu CW, Hsiao PJ, et al (2008). Association between polymorphisms in DNA base excision repair genes XRCC1, APE1, and ADPRT and differentiated thyroid carcinoma. Clin Cancer Res, 14, 5919-24. https://doi.org/10.1158/1078-0432.CCR-08-0906
  6. Chou WC, Wang HC, Wong FH, et al (2008). Chk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repair. EMBO J, 27, 3140-50. https://doi.org/10.1038/emboj.2008.229
  7. De Bont R, van Larebeke N (2004). Endogenous DNA damage in humans: a review of quantitative data. Mutagenesis, 19, 169-85. https://doi.org/10.1093/mutage/geh025
  8. Egger M, Davey Smith G, Schneider M, et al (1997). Bias in meta-analysis detected by a simple, graphical test. BMJ, 315, 629-34. https://doi.org/10.1136/bmj.315.7109.629
  9. Fard-Esfahani P, Fard-Esfahani A, Fayaz S, et al (2011). Association of Arg194Trp, Arg280His and Arg399Gln polymorphisms in X-ray repair cross-complementing group 1 gene and risk of differentiated thyroid carcinoma in Iran. Iran Biomed J, 15, 73-8.
  10. Garcia-Quispes WA, Perez-Machado G, Akdi A, et al (2011). Association studies of OGG1, XRCC1, XRCC2 and XRCC3 polymorphisms with differentiated thyroid cancer. Mutat Res, 709-710, 67-72. https://doi.org/10.1016/j.mrfmmm.2011.03.003
  11. Gilfillan CP (2010). Review of the genetics of thyroid tumours: diagnostic and prognostic implications. ANZ J Surg, 80, 33-40. https://doi.org/10.1111/j.1445-2197.2009.05173.x
  12. Gudmundsson J, Sulem P, Gudbjartsson DF, et al (2012). Discovery of common variants associated with low TSH levels and thyroid cancer risk. Nat Genet, 44, 319-22. https://doi.org/10.1038/ng.1046
  13. Hanssen-Bauer A, Solvang-Garten K, Sundheim O, et al (2011). XRCC1 coordinates disparate responses and multiprotein repair complexes depending on the nature and context of the DNA damage. Environ Mol Mutagen, 52, 623-35. https://doi.org/10.1002/em.20663
  14. Higgins J. P, Thompson SG, Deeks JJ, et al (2003). Measuring inconsistency in meta-analyses. BMJ, 327, 557-60. https://doi.org/10.1136/bmj.327.7414.557
  15. Ho T, Li G, Lu J, et al (2009). Association of XRCC1 polymorphisms and risk of differentiated thyroid carcinoma: a case-control analysis. Thyroid, 19, 129-35. https://doi.org/10.1089/thy.2008.0153
  16. Jendrzejewski J, He H, Radomska HS, et al (2012). The polymorphism rs944289 predisposes to papillary thyroid carcinoma through a large intergenic noncoding RNA gene of tumor suppressor type. Proc Natl Acad Sci USA, 109, 8646-51. https://doi.org/10.1073/pnas.1205654109
  17. Khan A, Smellie J, Nutting C, et al (2010). Familial nonmedullary thyroid cancer: a review of the genetics. Thyroid, 20, 795-801. https://doi.org/10.1089/thy.2009.0216
  18. Ming M, He YY (2012). PTEN in DNA damage repair. Cancer Lett, 319, 125-9. https://doi.org/10.1016/j.canlet.2012.01.003
  19. Moher D, Liberati A, Tetzlaff J, Altman DG (2009). Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med, 6, e1000097. https://doi.org/10.1371/journal.pmed.1000097
  20. Papadopoulou F, Efthimiou E (2008). Thyroid cancer after external or internal ionizing irradiation. Hell J Nucl Med, 12, 266-70.
  21. Parkin DM, Bray F, Ferlay J, et al (2005). Global cancer statistics, 2002. CA Cancer J Clin, 55, 74-108. https://doi.org/10.3322/canjclin.55.2.74
  22. Ryu RA, Tae K, Min HJ, et al (2011). XRCC1 polymorphisms and risk of papillary thyroid carcinoma in a Korean sample. J Korean Med Sci, 26, 991-5. https://doi.org/10.3346/jkms.2011.26.8.991
  23. Santos LS, Branco SC, Silva SN, et al (2012). Polymorphisms in base excision repair genes and thyroid cancer risk. Oncol Rep, 28, 1859-68. https://doi.org/10.3892/or.2012.1975
  24. Sigurdson AJ, Land CE, Bhatti P, et al (2009). Thyroid nodules, polymorphic variants in DNA repair and RET-related genes, and interaction with ionizing radiation exposure from nuclear tests in Kazakhstan. Radiat Res, 171, 77-88. https://doi.org/10.1667/RR1327.1
  25. Siraj AK, Al-Rasheed M, Ibrahim M, et al (2008). RAD52 polymorphisms contribute to the development of papillary thyroid cancer susceptibility in Middle Eastern population. J Endocrinol Invest, 31, 893-9. https://doi.org/10.1007/BF03346438
  26. Wallace SS, Murphy DL, Sweasy JB (2012). Base excision repair and cancer. Cancer Lett, 327, 73-89. https://doi.org/10.1016/j.canlet.2011.12.038
  27. Yi EXZ, Tang ZH (2012). X-Ray repair cross-complementing group 1 (XRCC1) genetic polymorphisms and thyroid carcinoma risk: a meta-analysis. Asian Pac J Cancer Prev, 13, 6385-90. https://doi.org/10.7314/APJCP.2012.13.12.6385
  28. Zharkov D (2008). Base excision DNA repair. Cell Mol Life Sci, 65, 1544-65. https://doi.org/10.1007/s00018-008-7543-2
  29. Zhu QX, Bian JC, Shen Q, et al (2004). Genetic polymorphisms in X-ray repair cross-complementing gene 1 and susceptibility to papillary thyroid carcinoma. Zhonghua Liu Xing Bing Xue Za Zhi, 25, 702-5.

Cited by

  1. A Cyclin D1 (CCND1) Gene Polymorphism Contributes to Susceptibility to Papillary Thyroid Cancer in the Turkish Population vol.15, pp.17, 2014, https://doi.org/10.7314/APJCP.2014.15.17.7181
  2. Association between MTHFR C677T polymorphism and thyroid cancer risk: a meta-analysis vol.35, pp.8, 2014, https://doi.org/10.1007/s13277-014-2038-2
  3. Association between the XRCC1 Polymorphisms and Thyroid Cancer Risk: A Meta-Analysis from Case-Control Studies vol.9, pp.9, 2014, https://doi.org/10.1371/journal.pone.0087764
  4. Polymorphism of the DNA Repair Gene XRCC1 (Arg194Trp) and its role in Colorectal Cancer in Kashmiri Population: a Case Control Study vol.16, pp.15, 2015, https://doi.org/10.7314/APJCP.2015.16.15.6385
  5. Thyroid Cancer Epidemiology in Iran: a Time Trend Study vol.17, pp.1, 2016, https://doi.org/10.7314/APJCP.2016.17.1.407
  6. Variant Alleles in XRCC1 Arg194Trp and Arg399Gln Polymorphisms Increase Risk of Gastrointestinal Cancer in Sabah, North Borneo vol.17, pp.4, 2016, https://doi.org/10.7314/APJCP.2016.17.4.1925
  7. Association of XRCC1 polymorphisms with arsenic methylation vol.90, pp.4, 2016, https://doi.org/10.1007/s00204-015-1490-0