Asian Pacific Journal of Cancer Prevention
- Volume 14 Issue 9
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- Pages.5237-5242
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- 2013
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- 1513-7368(pISSN)
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- 1513-7368(eISSN)
DOI QR Code
Are Neutrophil/Lymphocyte and Platelet/Lymphocyte Rates in Patients with Non-Small Cell Lung Cancer Associated with Treatment Response and Prognosis?
- Unal, Dilek (Department of Radiation Oncology, Kayseri Education and Research Hospital) ;
- Eroglu, Celalettin (Department of Radiation Oncology, Erciyes University Medical School) ;
- Kurtul, Neslihan (Department of Radiation Oncology, Erciyes University Medical School) ;
- Oguz, Arzu (Department of Medical Oncology, Kayseri Education and Research Hospital) ;
- Tasdemir, Arzu (Department of Pathology, Kayseri Education and Research Hospital)
- Published : 2013.09.30
Abstract
Background: Inflammation is a critical component of tumor progression. Many cancers arise from sites of infection, chronic irritation, and inflammation. It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an essential participant in the neoplastic process, promoting proliferation, survival and migration. Platelets can release some growth factors such as platelet-derived growth factor, platelet factor 4, and thrombospondin. Such factors have been shown to promote hematogenous tumour spread, tumor cell adhesion and invasion, and angiogenesis and to play an important role in tumor progression. In this study, we aimed to investigate effects of the pretreatment neutrophil to lymphocyte ratio (NLR) and the platelet to lymphocyte ratio (PLR) on survival and response to chemoradiotherapy in patients with non-small-cell lung cancer (NSCLC). Materials and Methods: Ninety-four patients with non-metastatic NSCLC were included and separated into two groups according to median valuse of NLR and PLR (low:<3.44 or high:
Keywords
Neutrophil to lymphocyte ratio;non-small-cell lung cancer;platelet to lymphocyte ratio;prognosis
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