- Volume 14 Issue 9
DOI QR Code
Physical Inactivity, Water Intake and Constipation as Risk Factors for Colorectal Cancer among Adults in Jordan
- Tayyem, Reema Fayez (Department of Clinical Nutrition and Dietetic, The Hashemite University) ;
- Shehadeh, Ihab Numan (Gastroenterology Division, KHCC) ;
- AbuMweis, Suhad Sameer (Department of Clinical Nutrition and Dietetic, The Hashemite University) ;
- Bawadi, Hiba Ahmad (Department of Nutrition and Food Technology, Hashemite University) ;
- Hammad, Shatha Sabri (Department of Clinical Nutrition and Dietetic, The Hashemite University) ;
- Bani-Hani, Kamal Eddin (Faculty of Medicine, Hashemite University) ;
- Al-Jaberi, Tareq Mohammad (Jordan University of Science and Technology) ;
- Alnusai, Majed Mohammed (Gastroenterology Division, Prince Hamza Hospital)
- Published : 2013.09.30
Background: Physical activity has been found to play a role in cancer prevention. The purpose of this matched case-control study was to investigate the association between physical activity levels, water intake, constipation and colorectal cancer (CRC). Materials and Methods: Two hundred and thirty-two patients diagnosed with CRC (125 male, 107 female) were enrolled in this case-control study. Cases were matched to 271 population controls (137 male, 134 female). Results: Drinking more than 4 cups of water daily decreased the risk of CRC by 33-42%; however, this effect was non-significant. Having constipation was found to be a significant risk factor for developing CRC with an OR=6.284 (95%CI=2.741-14.40). With reference to sedentary behavior, minimum activity (600-3000 Metabolic Equivalents Task (MET)) had 43% protection against CRC and the level of Health Enhancing Physical Activity OR was 0.58 (at 95%CI; 0.37-0.92). A significant negative association was found between CRC and physical activity levels expressed as both METs and MET-hours/week (p for trend=0.017 and 0.03, respectively). Among females, a significant trend of reduction in CRC by 62% was observed with increasing the level of physical activity expressed in MET (p for trend=0.04). Conclusions: The risk of CRC may be reduced by adopting a healthy lifestyle and practicing physically activity regularly, especially among females. Consuming adequate amounts of water and healthy bowel motility could also reduce the risk of CRC.
Colorectal cancer;physical activity;water intake;constipation
- Alharbi N, Alshammari M, Almutairi B, Makboul G, El-Shazly M (2012). Knowledge, awareness, and practices concerning breast cancer among Kuwaiti female school teachers. Alexandria J Med, 48, 75-82. https://doi.org/10.1016/j.ajme.2011.10.003
- Boutron-Ruault MC, Senesse P, Meance S, Belghiti C, Faivre J (2001). Energy intake, body mass index, physical activity, and the colorectal adenoma-carcinoma sequence. Nutr. Cancer, 39, 50-7. https://doi.org/10.1207/S15327914nc391_7
- Breslow R, Sorkin J, Frey C, Kessler L (1997). Americans' knowledge of cancer risk and survival. Prev Med, 26, 170-7. https://doi.org/10.1006/pmed.1996.0136
- Campbell P, Cotterchio M, Dicks E, et al (2007). Excess body weight and CRC risk in Canada: associations in subgroups of clinically defined familial risk of cancer. Cancer Epidemiol Biomarkers Prev, 16, 1735-44. https://doi.org/10.1158/1055-9965.EPI-06-1059
- Fu Z, Shrubsole M, Smalley W, et al (2012). Lifestyle factors and their combined impact on the risk of colorectal polyps. Am J Epidemiol, 176, 766-76. https://doi.org/10.1093/aje/kws157
- Clinton SK, Bostwick DG, Olson LM, Mangian HJ, Visek WJ (1988). Effects of ammonium acetate arid sodium cholate on N-methyl-N0-nitro-N-nitrosocolon colon carcinogenesis of rats. Cancer Res, 48, 3035-9.
- Dobrila-Dintinjana R, Trivanovic D, Zelic M, et al (2012). Nutritional support in patients with CRC during chemotherapy: does it work? Hepatogastroenterology, 60, 475-80.
- Friedenreich C, Orenstein M (2002). Physical activity and cancer prevention: etiologic evidence and biological mechanisms. J Nutr, 132, 3456-64. https://doi.org/10.1093/jn/132.11.3456S
- Giovannucci E (1995). Insulin and colon cancer. Cancer Causes Control, 6, 164-79. https://doi.org/10.1007/BF00052777
- Iber FL, Parveen S, Vandrunen M, et al (1993). Relation of symptoms to impaired stomach, small bowel, and colon motility in long-standing diabetes. Dig Dis Sci, 38, 45-50. https://doi.org/10.1007/BF01296772
- Kotake K, Koyama Y, Nasu J, Fukutomi T, Yamaguchi N (1995). Relation of family history of cancer and environmental factors to the risk of CRC: a case-control study. Jpn J Clin Oncol, 25, 195-202.
- Kune GA, Kune S, Watson LF (1990). Body weight and physical activity as predictors of CRC risk. Nutr Cancer, 13, 9-17. https://doi.org/10.1080/01635589009514041
- Lee IM, Paffenbarger RS Jr, Hsieh C (1991). Physical activity and risk of developing CRC among college alumni. J Natl Cancer Inst, 83, 1324-9. https://doi.org/10.1093/jnci/83.18.1324
- Lee RD, Nieman DC (2010). Nutritional Assessment. 5th ed. New York: McGraw Hill.
- Meyerhardt J, Giovannucci E, Holmes M, et al (2006). Physical activity and survival after CRC diagnosis. J Clin Oncol, 24, 3527-34. https://doi.org/10.1200/JCO.2006.06.0855
- Marchand L, Wilkens L, Kolonel L, Hankin J, Lyu LC (1997). Associations of sedentary lifestyle, obesity, smoking, alcohol use, and diabetes with the risk of CRC. Cancer Research, 57, 4787-94.
- McKeown-Eyssen G (1994). Epidemiology of CRC revisited: are serum triglycerides and/or plasma glucose associated with risk? Cancer Epidemiol Biomarkers Prev, 3, 687-95.
- McTiernan A (2008). Mechanisms linking physical activity with cancer. Nat Rev Cancer, 8, 205-11. https://doi.org/10.1038/nrc2325
- Nakamura T, Imamura K, Kasai F, et al (1993). Fecal excretions of hydroxy fatty acid and bile acid in diabetic diarrheal patients. J Diabetes Complications, 7, 8-11. https://doi.org/10.1016/1056-8727(93)90017-S
- Narisawa T, Magadia NE, Weisburger JH, Wynder EL (1974). Promoting effect of bile acids on colon carcinogenesis after intrarectal instillation of N-methyl-N'-nitro-Nnitrosoguanidine in rats. J Natl Cancer Inst, 53, 1093-7. https://doi.org/10.1093/jnci/53.4.1093
- Nilsen T, Vatten L (2001). Prospective study of CRC risk and physical activity, diabetes, blood glucose and BMI: exploring the hyperinsulinaemia hypothesis. Bri J Cancer, 84, 417-22. https://doi.org/10.1054/bjoc.2000.1582
- Peppone L, Hyland A, Moysich K, et al (2009). Examining the association between cigarette smoking and CRC using historical case-control data. Cancer Epidemiol, 33, 182-8. https://doi.org/10.1016/j.canep.2009.07.004
- Peters RK, Garabrant DH, Yu MC, Mack T (1989). A casecontrol study of occupational and dietary factors in CRC in young men by subsite. Cancer Res, 49, 5459-68.
- Reddy BS, Watanabe K, Weisburger JH, Wynder EL (1977). Promoting effect of bile acids in colon carcinogenesis in germ-free and conventional F344 rats. Cancer Res, 37, 3238-42.
- Shannon J, White E, Shattuck A L, Potter JD (1996). Relationship of food groups and water intake to colon cancer risk. Cancer Epidemiol Biomarkers Prev, 5, 495-502.
- Roberts M, Millikan R, Galanko J, Martin C, Sandler R (2003). Constipation, laxative use, and colon cancer in a North carolina population. Am J Gastroenterol, 98, 857-64. https://doi.org/10.1111/j.1572-0241.2003.07386.x
- Sallis JF, Haskell WL, Wood PD (1985). Physical activity assessment methodology in the five-city project. Am J Epidemiol. 121, 91-106. https://doi.org/10.1093/oxfordjournals.aje.a113987
- Sanchez-Lara K, Ugalde-Morales E, Motola-Kuba D, Green D (2013). Gastrointestinal symptoms and weight loss in cancer patients receiving chemotherapy. Br J Nutr, 109, 894-7. https://doi.org/10.1017/S0007114512002073
- Simons C, Hughes L, Engeland M, et al (2013). Physical activity, occupational sitting time, and CRC risk in the Netherlands cohort study. Am J Epidemiol, 177, 514-30. https://doi.org/10.1093/aje/kws280
- Slattery ML, Ballard-Barbash R, Edwards S, Caan BJ, Potter JD (2003). Body mass index and colon cancer: an evaluation of the modifying effects of estrogen (United States). Cancer Causes Control, 14, 75-84. https://doi.org/10.1023/A:1022545017867
- Slattery M L, Edwards S, Curtin K, et al (2003). Physical activity and CRC. Am J Epidemiol, 158, 214-24. https://doi.org/10.1093/aje/kwg134
- Steindorf K, Tobiasz-Adamczyk B, Popiela T, et al (2000). Combined risk assessment of physical activity and dietary habits on the development of CRC. A hospital-based casecontrol study in Poland. Eur J Cancer Prev, 9, 309-16. https://doi.org/10.1097/00008469-200010000-00004
- Stewart BW, Kleihues P (2003). World cancer report. Geneva, World Health Organization/Lyon, International Agency for Research on Cancer.
- Tang R, Wang J, LO S, Hsieh L (1999). Physical activity, water intake and risk of CRC in Taiwan: a hospital-based casecontrol study. Int J Cancer, 82, 484-9. https://doi.org/10.1002/(SICI)1097-0215(19990812)82:4<484::AID-IJC3>3.0.CO;2-A
- Wolin K, Tuchman H (2011). Physical activity and gastrointestinal cancer prevention. Recent Results Cancer Res, 186, 73-100.
- Thune I, Lund E (1996). Physical activity and risk of CRC in men and women. Bri J Cancer, 73, 1134-40. https://doi.org/10.1038/bjc.1996.218
- Ugajin H (1989). The role of bile acids with physiological concentration in colon carcinogenesis. Nippon Shoukakibyo Gakkai Zasshi, 86, 1627-37.
- Whittemore A, Wu-Williams A, Lee M, et al (1990). Diet, physical activity, and CRC among Chinese in North America and China. J Natl Cancer Inst, 82, 915-26. https://doi.org/10.1093/jnci/82.11.915
- Wu AH, Paganini-Hill A, Ross RK, Henderson BE (1987). Alcohol, physical activity and other risk factors for CRC: a prospective study. Bri J Cancer, 55, 687-94. https://doi.org/10.1038/bjc.1987.140
- Zarkovic M, Qin X, Nakatsuru Y, et al (1993). Tumor promotion by fecapentaene-12 in a rat colon carcinogenesis model. Carcinogenesis, 14, 1261-4. https://doi.org/10.1093/carcin/14.7.1261
- Awareness of Risk Factors for Cancer among Omani adults- A Community Based Study vol.15, pp.13, 2014, https://doi.org/10.7314/APJCP.2014.15.13.5401
- Health and Economic Costs of Physical Inactivity vol.15, pp.18, 2014, https://doi.org/10.7314/APJCP.2014.15.18.7499
- Physical Activity and Cancer Prevention: Awareness and Meeting the Recommendations among Adult Saudis vol.15, pp.6, 2014, https://doi.org/10.7314/APJCP.2014.15.6.2597
- Nanocrystalline cerium dioxide efficacy for gastrointestinal motility: potential for prokinetic treatment and prevention in elderly vol.6, pp.1, 2015, https://doi.org/10.1186/s13167-015-0029-z
- Consumption of Whole Grains, Refined Cereals, and Legumes and Its Association With Colorectal Cancer Among Jordanians vol.15, pp.3, 2016, https://doi.org/10.1177/1534735415620010
- Food properties and dietary habits in colorectal cancer prevention and development vol.20, pp.10, 2017, https://doi.org/10.1080/10942912.2016.1236813