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Targeted Silencing of Inhibitors of Apoptosis Proteins with siRNAs: A Potential Anti-cancer Strategy for Hepatocellular Carcinoma

  • Li, Gang (Department of General Surgery, Provincial Hospital Afficiated to Shandong University, Shandong University) ;
  • Chang, Hong (Department of General Surgery, Provincial Hospital Afficiated to Shandong University, Shandong University) ;
  • Zhai, Yun-Peng (Department of General Surgery, Provincial Hospital Afficiated to Shandong University, Shandong University) ;
  • Xu, Wei (Department of General Surgery, Provincial Hospital Afficiated to Shandong University, Shandong University)
  • Published : 2013.09.30

Abstract

Hepatocellular carcinoma (HCC) is one of the most common malignancies, with a very poor prognosis. Despite significant improvements in diagnosis and treatment in recent years, the long-term therapeutic efficacy is poor, partially due to tumor metastasis, tecurrence, and resistance to chemo-or radio-therapy. Recently, it was found that a major feature of tumors is a combination of unrestrained cell proliferation and impaired apoptosis. There are now 8 recogized members of the IAP-family: NAIP, c-IAP1, c-IAP2, XIAP, Survivin, Bruce, Livin and ILP-2. There proteins all contribute to ingibition of apoptosis, and provide new potential avenues of cancer treatment. As a powerful tool to suppress gene expression in mammalian cells, RNAi species for inhibiting IAP genes cab be directed against cancers. This review will provide a brief introduction to recent developments of the application IAP-siRNA in tumor studies, with the aim of inspiring future treatment of HCC.

Keywords

Hepatocellular carcinoma;IAP;caspase;siRNA;therapy

Acknowledgement

Supported by : National Science Foundation

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