Change in Pulpal Blood Flow of Heat-induced Neurogenic Inflammation in Feline Dental Plup

고양이 치수에서 열 자극으로 유도된 신경병증 염증에서 치수 혈류량 변화

  • 박민경 (경운대대학교 치위생학과)
  • Received : 2013.10.17
  • Accepted : 2013.12.05
  • Published : 2013.12.31


This study examined the involvement of histamine in heat-induced changes in pulpal blood flow(PBF) to determine the mechanism of neurogenic inflammation in feline dental pulp. The experiments were carried out in 10 felines anesthetized with sodium pentobartial and histamine injected into the dental pulp through the external carotid artery. The change in the pulpal PBF was measured using a laser Doppler flowmeter(Periflux 4001, Stockholm, Sweden). The probe of laser Doppler flowmeter was placed on the buccal surface of the ipsilateral canine teeth. Heat was applied to the tooth using a heat stimulator controlled script file with an input/output device. The application of heat ($40-65^{\circ}C$) induced a significant increase in PBF. The application of histamine($5{\mu}g/kg/1ml$) followed by heat($45^{\circ}C$) resulted in an increase in PBF. Therefore, the results of the present study showed that heat and histamine are capable of vasoconstriction caused by neurogenic inflammation in feline dental pulp. In addition, neurogenic inflammation plays an active role in modulating the microcirculation of the dental pulp.


Heat;Histamine;Neurogenic Inflammation;Pulp Blood Flow


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