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Characterization and Transdermal Delivery of Ethosomes Loaded with Eucommia ulmoides Extract

두충 추출물을 담지한 에토좀의 특성 및 경피 전달

  • Gu, Hyun A (Department of Fine Chemistry, Nanobiocosmetic Laboratory and Cosmetic R&D Center, Seoul National University of Science and Technology) ;
  • Kim, Hae Soo (Department of Fine Chemistry, Nanobiocosmetic Laboratory and Cosmetic R&D Center, Seoul National University of Science and Technology) ;
  • Kim, Moon Jin (Department of Fine Chemistry, Nanobiocosmetic Laboratory and Cosmetic R&D Center, Seoul National University of Science and Technology) ;
  • Yu, Eun Ryeong (Department of Fine Chemistry, Nanobiocosmetic Laboratory and Cosmetic R&D Center, Seoul National University of Science and Technology) ;
  • Joe, Gijung (Somang Cosmetics Co., Ltd.) ;
  • Jang, Jindong (Somang Cosmetics Co., Ltd.) ;
  • Kim, Bohyeon (Somang Cosmetics Co., Ltd.) ;
  • Park, Soo Nam (Department of Fine Chemistry, Nanobiocosmetic Laboratory and Cosmetic R&D Center, Seoul National University of Science and Technology)
  • 구현아 (서울과학기술대학교 정밀화학과 나노바이오화장품연구실, 화장품종합기술연구소) ;
  • 김해수 (서울과학기술대학교 정밀화학과 나노바이오화장품연구실, 화장품종합기술연구소) ;
  • 김문진 (서울과학기술대학교 정밀화학과 나노바이오화장품연구실, 화장품종합기술연구소) ;
  • 유은령 (서울과학기술대학교 정밀화학과 나노바이오화장품연구실, 화장품종합기술연구소) ;
  • 조기정 (소망화장품(주)) ;
  • 장진동 (소망화장품(주)) ;
  • 김보현 (소망화장품(주)) ;
  • 박수남 (서울과학기술대학교 정밀화학과 나노바이오화장품연구실, 화장품종합기술연구소)
  • Received : 2013.08.07
  • Accepted : 2013.09.10
  • Published : 2013.12.10

Abstract

In this study, ethosomes loaded with Eucommia ulmoides extracts that have anti-inflammatory and anti-aging activities on the skin were prepared as cosmetic materials. The particle size, physical property, and entrapment efficiency of ethosomes to identify their stabilities during 4 weeks were measured. Ethosomes containing 0.01~0.05% E. ulmoides extracts did not show either precipitation or separation. The mean particle size of these ethosomes was 136.4 nm, and monodisperse. The particle size of ethosome containing 0.05% E. ulmoides extracts was 151.15 nm and the entrapment efficiency was 81.79%. Therefore, in vitro skin permeation experiment was performed with ethosome containing 0.05% E. ulmoides extracts that showed the high loading efficiency and stability during 4 weeks. The order of skin permeation of E. ulmoides extracts was ethosome (77.16%) > liposome (62.80%) > ethanolic solutoin (41.59%). These results suggest that ethosomes containing 0.05% E. ulmoides extracts are effective for the skin permeation and may be used as a cosmetic formulation containing plant extracts.

Acknowledgement

Supported by : 지식경제부

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