Sleep-Induction Effects of GABA Coated Rice from Fermentation of Mono Sodium Glutamate

Mono Sodium Glutamate 발효로 얻은 GABA 코팅 쌀에 의한 수면유도 효과

  • Kim, Ok Ju (Department of Bioscience and Biotechnology, Graduate School, Silla University) ;
  • Lee, Jeong Kwang (Department of Pharmaceutical Engineering, College of Medical & Life Science, Silla University) ;
  • Woo, Young Min (Department of Pharmaceutical Engineering, College of Medical & Life Science, Silla University) ;
  • Choi, Seung Tae (Full & Fill Bio) ;
  • Park, Mi Yeon (Full & Fill Bio) ;
  • Kim, Andre (Department of Pharmaceutical Engineering, College of Medical & Life Science, Silla University) ;
  • Ha, Jong-Myung (Department of Bioscience and Biotechnology, Graduate School, Silla University)
  • Received : 2013.06.17
  • Accepted : 2013.08.29
  • Published : 2013.12.10


Gamma-aminobutyric acid (GABA) is a non-protein amino acid widely present in organisms, which has shown several important physiological functions such as neurotransmission, hypotension induction, as well as diuretic and tranquilizer effects. They have also been extensively used in food industry. GABA contents in the grain and brown rice are about 1~4 mg/100 g and 4~8 mg/100 g, respectively but it is difficult to expect physiological activity from such low amounts of natural food intake. We investigate the effects of GABA-coated rice on the secretion of melatonin and serotonin which both have been used as sleep inductive compounds. As a result, the secretion of melatonin and serotonin from mice were found to be $3.578{\pm}0.158pg/mL$, $5.918{\pm}0.169ng/mL$ respectively. The melatonin and serotonin in mice increased significantly up to the 8.7 and 22.8 times respectively, when compared to that of the rice, but there was no cumulative effects. Due to the continuous intake of GABA-coated rice, which was developed as a functional food nutrient, inductive effects of melatonin and serotonin from general rice could be achieved and also the similar effect as taking up directly 25 mg/mL of GABA could be obtained.


Supported by : 농림수산식품부


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