Neurobiology of Aggression

공격성의 신경생물학

  • Kim, Ki Won (Department of Psychiatry, Yong-In Mental Hospital) ;
  • An, Eun-Soog (Department of Psychiatry, Yong-In Mental Hospital) ;
  • Lee, Yu-Sang (Department of Psychiatry, Yong-In Mental Hospital) ;
  • Park, Seon-Cheol (Department of Psychiatry, Yong-In Mental Hospital)
  • 김기원 (용인정신병원 정신건강의학과) ;
  • 안은숙 (용인정신병원 정신건강의학과) ;
  • 이유상 (용인정신병원 정신건강의학과) ;
  • 박선철 (용인정신병원 정신건강의학과)
  • Received : 2013.07.08
  • Accepted : 2013.09.16
  • Published : 2013.11.30

Abstract

Aggression can be defined as 'behavior intended to harm another' which can be seen both from humans and animals. However, trying to understand aggression in a simplistic view may make it difficult to develop an integrated approach. So, we tried to explain aggression in a multidisciplinary approach, affected by various factors such as neuroanatomical structures, neurotransmitter, genes, and sex hormone. Parallel with animal models, human aggression can be understood with two phenomena, offensive aggression and defensive aggression. Neurobiological model of aggression give a chance to explain aggression with an imbalance between prefrontal regulatory influences and hyper-reactivity of the subcortical areas involved in affective evaluation, finally in an aspect of brain organization. Serotonin and GABA usually inhibit aggression and norepinephrine while glutamate and dopamine precipitate aggressive behavior. As there is no one gene which has been identified as a cause of aggression, functions between gene to gene interaction and gene to environment interaction are being magnified. Contributions of sex hormone to aggression, especially molecular biologic interaction of testosterone and regulation of estrogen receptor have been emphasized during the research on aggression. This multidisciplinary approach on aggression with types, neurochemical bases, and animal models can bring integrated interpretation on aggression.

Acknowledgement

Supported by : Ministry of Health and Welfare

References

  1. Nelson RJ, Trainor BC. Neural mechanisms of aggression. Nat Rev Neurosci 2007;8:536-546. https://doi.org/10.1038/nrn2174
  2. Campbell RJ. Campbell' s Psychiatric Dictionary. 10th ed. Oxford: Oxford University Press;2009.
  3. Victoroff J. Human aggression. In: Sadock BJ, Sadock VA, Ruiz P, editors. Kaplan and Sadock' s comprehensive textbook of psychiatry. 7th ed. New York: Lippincott Wiliams and Wilkins;2009. p.2671- 2702.
  4. Umukoro S, Aladeokin AC, Eduviere AT. Aggressive behavior: a comprehensive review of its neurochemical mechanisms and management. Aggression and Violent Behavior 2013;18:195-203. https://doi.org/10.1016/j.avb.2012.11.002
  5. Lane SD, Kjome KL, Moeller FG. Neuropsychiatry of aggression. Neurol Clin 2011;29:49-vii. https://doi.org/10.1016/j.ncl.2010.10.006
  6. Siever LJ. Neurobiology of aggression and violence. Am J Psychiatry 2008;165:429-442.17. https://doi.org/10.1176/appi.ajp.2008.07111774
  7. Park SC. Neurobiology of aggression. In: Proceedings of the Annual Autumn Conference of the Korean Society for Biological Psychiatry; 2013 April 5, Seoul, Korea. p.102-112.
  8. Stoff DM, Susman EJ. Developmental psychobiology of aggression. Cambridge: Cambridge University Press;2005.
  9. Blanchard DC, Blanchard RJ. What can animal aggression research tell us about human aggression? Horm Behav 2003;44:171-177. https://doi.org/10.1016/S0018-506X(03)00133-8
  10. Ahn SK. Neurobiological understanding of violence. In: Proceedings of the Annual Autumn Conference of the Korean Society for Biological Psychiatry;2012 April 6, Seoul, Korea. p.41-46.
  11. Ahn SK. Psychopharmacology of violent behavior. In: Lee HS, editor. Clinical Neuropsychopharmacology. Seoul: ML communications Co. Ltd.;2008. p.676-686.
  12. Adams DB. Brain mechanisms of aggressive behavior: an updated review. Neurosci Biobehav Rev 2006;30:304-318. https://doi.org/10.1016/j.neubiorev.2005.09.004
  13. Blair RJ. The roles of orbital frontal cortex in the modulation of antisocial behavior. Brain Cogn 2004;55:198-208. https://doi.org/10.1016/S0278-2626(03)00276-8
  14. Davidson RJ, Putnam KM, Larson CL. Dysfunction in the neural circuitry of emotion regulation--a possible prelude to violence. Science 2000;289:591-594. https://doi.org/10.1126/science.289.5479.591
  15. Green RG. Human aggression: mapping social psychology. 2nd ed. Berkshire: Open University Press;2001.
  16. Karli P. The neurobiology of aggressive behaviour. C R Biol 2006; 329:460-464. https://doi.org/10.1016/j.crvi.2005.11.007
  17. Mattson MP. Neurobiology of aggression: understanding and preventing violence. Totowa: Humana Press;2003.
  18. Sugden SG, Kile SJ, Hendren RL. Neurodevelopmental pathways to aggression: a model to understand and target treatment in youth. J Neuropsychiatry Clin Neurosci 2006;18:302-317. https://doi.org/10.1176/appi.neuropsych.18.3.302
  19. Filley CM, Price BH, Nell V, Antoinette T, Morgan AS, Bresnahan JF, et al. Toward an understanding of violence: neurobehavioral aspects of unwarranted physical aggression: Aspen Neurobehavioral Conference consensus statement. Neuropsychiatry Neuropsychol Behav Neurol 2001;14:1-14.
  20. Brower MC, Price BH. Neuropsychiatry of frontal lobe dysfunction in violent and criminal behaviour: a critical review. J Neurol Neurosurg Psychiatry 2001;71:720-726. https://doi.org/10.1136/jnnp.71.6.720
  21. Craig IW. The importance of stress and genetic variation in human aggression. Bioessays 2007;29:227-236. https://doi.org/10.1002/bies.20538
  22. Minzenberg MJ, Fan J, New AS, Tang CY, Siever LJ. Fronto-limbic dysfunction in response to facial emotion in borderline personality disorder: an event-related fMRI study. Psychiatry Res 2007;155:231- 243. https://doi.org/10.1016/j.pscychresns.2007.03.006
  23. Park SC. Cerebral asymmetry. In: Proceedings of Annual Spring Conference, Korean Society of Biological Therapies in Psychiatry; 2013 March 9, Gwangju, Korea, p.141-156.
  24. Rohlfs P, Ramirez JM. Aggression and brain asymmetries: a theoretical review. Aggress Violent Behav 2006;11:283-297. https://doi.org/10.1016/j.avb.2005.09.001
  25. Hennig J, Reuter M, Netter P, Burk C, Landt O. Two types of aggression are differentially related to serotonergic activity and the A779C TPH polymorphism. Behav Neurosci 2005;119:16-25. https://doi.org/10.1037/0735-7044.119.1.16
  26. de Almeida RM, Ferrari PF, Parmigiani S, Miczek KA. Escalated aggressive behavior: dopamine, serotonin and GABA. Eur J Pharmacol 2005;526:51-64. https://doi.org/10.1016/j.ejphar.2005.10.004
  27. de Almeida RM, Miczek KA. Aggression escalated by social instigation or by discontinuation of reinforcement ("frustration") in mice: inhibition by anpirtoline: a 5-HT1B receptor agonist. Neuropsychopharmacology 2002;27:171-181. https://doi.org/10.1016/S0893-133X(02)00291-9
  28. Miczek KA, Fish EW. Monoamine, GABA, Glutamate, and Aggression. In: Nelson RJ, editor. Biology of Aggression. New York: Oxford University Press;2006. p.114-149.
  29. Brown GL, Goodwin FK, Ballenger JC, Goyer PF, Major LF. Aggression in humans correlates with cerebrospinal fluid amine me tabolites. Psychiatry Res 1979;1:131-139. https://doi.org/10.1016/0165-1781(79)90053-2
  30. Goedhard LE, Stolker JJ, Heerdink ER, Nijman HL, Olivier B, Egberts TC. Pharmacotherapy for the treatment of aggressive behavior in general adult psychiatry: A systematic review. J Clin Psychiatry 2006;67:1013-1024. https://doi.org/10.4088/JCP.v67n0702
  31. van Erp AM, Miczek KA. Aggressive behavior, increased accumbal dopamine, and decreased cortical serotonin in rats. J Neurosci 2000; 20:9320-9325.
  32. de Boer SF, Lesourd M, Mocaer E, Koolhaas JM. Selective antiaggressive effects of alnespirone in resident-intruder test are mediated via 5-hydroxytryptamine1A receptors: A comparative pharmacological study with 8-hydroxy-2-dipropylaminotetralin, ipsapirone, buspirone, eltoprazine, and WAY-100635. J Pharmacol Exp Ther 1999;288:1125-1133.
  33. Lesch KP, Merschdorf U. Impulsivity, aggression, and serotonin: a molecular psychobiological perspective. Behav Sci Law 2000;18: 581-604. https://doi.org/10.1002/1099-0798(200010)18:5<581::AID-BSL411>3.0.CO;2-L
  34. McAndrew FT. Interacting roles of testosterone and challenges to status in human male aggression. Aggress Violent Behav 2009;14:330- 335. https://doi.org/10.1016/j.avb.2009.04.006
  35. Simon NG, Lu S. Androgens and Aggression. In: Nelson RJ, editor. Biology of Aggression. New York: Oxford University Press;2006. p.211-230.
  36. Yang LY, Verhovshek T, Sengelaub DR. Brain-derived neurotrophic factor and androgen interact in the maintenance of dendritic morphology in a sexually dimorphic rat spinal nucleus. Endocrinology 2004; 145:161-168. https://doi.org/10.1210/en.2003-0853
  37. Simon NG, Cologer-Clifford A, Lu SF, McKenna SE, Hu S. Testosterone and its metabolites modulate 5HT1A and 5HT1B agonist effects on intermale aggression. Neurosci Biobehav Rev 1998;23:325- 336. https://doi.org/10.1016/S0149-7634(98)00034-7
  38. Nelson RJ. Affiliative and aggressive behavior. In: An introduction to behavioral endocrinology. 2nd ed. Sunderland: Sinauer;2000. p.395- 445.
  39. Miczek KA, Fish EW, De Bold JF, De Almeida RM. Social and neural determinants of aggressive behavior: pharmacotherapeutic targets at serotonin, dopamine and gamma-aminobutyric acid systems. Psychopharmacology (Berl) 2002;163:434-458. https://doi.org/10.1007/s00213-002-1139-6
  40. Ogawa S, Nomura M, Choleris E, Pfaff D. The role of estrogen receptors in the regulation of aggressive behaviors. In: Nelson RJ, editor. Biology of Aggression. New York: Oxford Univ Press;2005. p.231-249.
  41. Miczek KA, Maxson SC, Fish EW, Faccidomo S. Aggressive behavioral phenotypes in mice. Behav Brain Res 2001;125:167-181. https://doi.org/10.1016/S0166-4328(01)00298-4