랫드를 이용한 황기의 지상부 추출물에 대한 90일 반복경구투여 독성시험

DOI QR코드

DOI QR Code

박영철;이지선;김동윤;손혜영;이정우;최유순;김광기;유창연;정일민;임무혁;이경재;최리나;심훈섭;임정대
Park, Yeong Chul;Lee, Ji Sun;Kim, Dong Yoon;Son, Hye Young;Lee, Jung Woo;Cheoi, Yu Soon;Kim, Kwang Ki;Yu, Chang Yeon;Chung, Ill Min;Im, Moo Hyeog;Lee, Kyung Jae;Choi, Ri Na;Shim, Hoon Seob;Lim, Jung Dae

  • 투고 : 2013.09.06
  • 심사 : 2013.11.27
  • 발행 : 2013.12.30

초록

Pharmacological studies and clinical practices have indicated that Radix Astragali, a dried root of Astragalus membranaceus possesses a lot of biological activities, including antioxidant, hepatoprotective, anti-diabetic, tonic, diuretic, antimicrobial, antiviral, and immunological activities. These biological activities approved by the modern pharmacological studies are mainly due to the constituents of Astragalus membranaceus including polysaccharides, saponins, flavonoids, amino acids, and trace elements. In resent, the main constituents in the root part showing a lot of biological activities has been isolated also from the aboveground parts such as leaves and sprouts in our laboratory. However, the safety evaluation for the aboveground parts of Astragalus membranaceus should be checked before expanding their application as one of food. In the study, a 90-day rat oral gavage study has been conducted with the extracts from Astragalus membranaceus-above-ground parts at doses of 1000, 3000, and 5000mg/kg/day. The following endpoints were evaluated: clinical observations, body weight, gross and microscopic pathology, clinical chemistry, and hematology. Based on the analysis of these endpoints, it was estimated that NOEL (no observed effect level) for male rats and NOAEL (no observed adverse effect level) for female rats are 5000mg/kg/day of the water-extracts from Astragalus membranaceus-aboveground parts.

키워드

Astragalus membranaceus;Aboveground Parts;NOAEL;Toxicity

참고문헌

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피인용 문헌

  1. 1. Production of Adventitious Root and Analysis of Effective Components from in vitro Culture of Astragalus membranaceus vol.23, pp.5, 2015, doi:10.7783/KJMCS.2013.21.6.474
  2. 2. Repeated Dose 90-Day Oral Toxicity Study of Dried Thermitomyces albuminosus Powder in Rats vol.26, pp.10, 2016, doi:10.7783/KJMCS.2013.21.6.474
  3. 3. Genotoxicity Study of Polysaccharide Fraction from Astragalus membranaceus's Aerial Parts vol.30, pp.2, 2014, doi:10.7783/KJMCS.2013.21.6.474
  4. 4. Osteoprotective Effect of Extract from Cirsium japonicum var. ussuriense in Ovariectomized Rats vol.23, pp.1, 2015, doi:10.7783/KJMCS.2013.21.6.474
  5. 5. A 28 Day Repeated Dose-Oral Toxicity Studies of Arisaema Rhizome Aqueous Extracts in Sprague-Dawley Rats vol.28, pp.4, 2015, doi:10.7783/KJMCS.2013.21.6.474