Antimicrobial Effect of Ursolic Acid and Oleanolic Acid against Methicillin-Resistant Staphylococcus aureus

Ursolic Acid와 Oleanolic Acid의 메티실린 저항성 Staphylococcus aureus에 대한 항균작용

  • Kim, Saeng-Gon (Department of Human Biology, School of Dentistry, Chosun University) ;
  • Kim, Min-Jung (Korean Collection for Oral Microbiology and Department of Oral Biochemistry, School of Dentistry, Chosun University) ;
  • Jin, Dong-Chun (Department of Veterinary Medicine, College of Agriculture, Yanbian University) ;
  • Park, Soon-Nang (Korean Collection for Oral Microbiology and Department of Oral Biochemistry, School of Dentistry, Chosun University) ;
  • Cho, Eu-Gene (Korean Collection for Oral Microbiology and Department of Oral Biochemistry, School of Dentistry, Chosun University) ;
  • Freire, Marcelo Oliveira (Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Harvard University) ;
  • Jang, Sook-Jin (Department of Laboratory Medicine, Chosun University Medical School) ;
  • Park, Young-Jin (Department of Laboratory Medicine, Chosun University Medical School) ;
  • Kook, Joong-Ki (Korean Collection for Oral Microbiology and Department of Oral Biochemistry, School of Dentistry, Chosun University)
  • 김생곤 (조선대학교 치과대학 인체생물학교실) ;
  • 김민정 (조선대학교 치과대학 구강생화학교실 및 한국구강미생물자원은행) ;
  • 김동춘 (중국 연변대학교 농학원 동물의학교실) ;
  • 박순낭 (조선대학교 치과대학 구강생화학교실 및 한국구강미생물자원은행) ;
  • 조유진 (조선대학교 치과대학 구강생화학교실 및 한국구강미생물자원은행) ;
  • 마르셀로 올리베이라 프레리 (미국 하버드 치의학대학원 구강내과, 감염 및 면역학교실) ;
  • 장숙진 (조선대학교 의과대학 진단검사의학과) ;
  • 박영진 (조선대학교 의과대학 진단검사의학과) ;
  • 국중기 (조선대학교 치과대학 구강생화학교실 및 한국구강미생물자원은행)
  • Received : 2012.07.13
  • Accepted : 2012.09.07
  • Published : 2012.09.30


The antimicrobial activity of ursolic acid (UA) and oleanolic acid (OA), both triterpenoid compounds, against methicillin-resistant Staphylococcus aureus (MRSA) is controversial. We examined the antimicrobial effects of UA and OA against 19 strains of MRSA isolated from Koreans by determining minimum inhibitory concentrations (MIC) and minimum bactericidal concentrations (MBC). The data showed that the methicillin-sensitive strain S. aureus KCTC $1621^T$ was more resistant to UA and OA than that of the MRSA strains. The MBC values of UA and OA against MRSA had broad ranges; 4 to 32 ${\mu}g/ml$ and 16 to >256 ${\mu}g/ml$, respectively. It was difficult to understand the different antimicrobial activities of UA and OA among the MRSA strains, because UA and OA antimicrobial mechanisms are unknown. These results indicate that the antimicrobial effects of UA and OA against MRSA are dependent on resistance to UA and OA in each strain.


antimicrobial effect;methicillin-resistant Staphylococcus aureus;oleanolic acid;ursolic acid


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