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Serotype Distribution of Human Respiratory Adenovirus Isolated in Gyeonggi Province

경기도내에서 분리한 호흡기아데노바이러스의 혈청형 분포특성

  • Lee, Hyun-Kyung (Virus Team, Gyeonggi-do Institute of Health and Environment) ;
  • Lee, Myung-Jin (Virus Team, Gyeonggi-do Institute of Health and Environment) ;
  • Mun, Su-Kyoung (Virus Team, Gyeonggi-do Institute of Health and Environment) ;
  • Kim, Woon-Ho (Virus Team, Gyeonggi-do Institute of Health and Environment) ;
  • Cho, Han-Gil (Virus Team, Gyeonggi-do Institute of Health and Environment) ;
  • Yoon, Mi-Hye (Virus Team, Gyeonggi-do Institute of Health and Environment) ;
  • Lee, Jong-Bok (Virus Team, Gyeonggi-do Institute of Health and Environment) ;
  • Cheong, Hyang-Min (Division of Respiratory Viruses, National Institute of Health, Korea Centers for Disease Control and Prevention)
  • 이현경 (경기도보건환경연구원 바이러스팀) ;
  • 이명진 (경기도보건환경연구원 바이러스팀) ;
  • 문수경 (경기도보건환경연구원 바이러스팀) ;
  • 김운호 (경기도보건환경연구원 바이러스팀) ;
  • 조한길 (경기도보건환경연구원 바이러스팀) ;
  • 윤미혜 (경기도보건환경연구원 바이러스팀) ;
  • 이정복 (경기도보건환경연구원 바이러스팀) ;
  • 정향민 (질병관리본부 호흡기바이러스과)
  • Received : 2012.05.15
  • Accepted : 2012.07.20
  • Published : 2012.09.30

Abstract

Adenoviruses are an important cause of respiratory tract infections, particularly in infants, young children, and immuno-compromised patients. In this study, we investigated the characteristics of adenoviruses isolated from outpatients with acute respiratory illness in Gyeonggi province of South Korea during 2009-2011. Adenoviruses were detected in 102 of 1,622 (6.3%) specimens by using PCR or real-time PCR with viral specific primers. 76 isolates were obtained from 102 specimens using the A549 cells. Serotypic distributions of isolated adenovirus were analyzed by sequencing of hexon gene. Six different serotypes were identified, which included adenovirus serotypes 1-6. Adenovirus 3 (n=40, 52.6%) was the predominant serotype. The predominant types of adenovirus every year were serotypes 1 and 3 in 2009, serotype 3 in 2010, and serotype 5 in 2011, respectively. Adenoviruses 1, 2, 4, 5, and 6 were isolated sporadically throughout the study period. Adenovirus 3 was present both during outbreaks and in sporadic cases. These results indicate that adenovirus 3 played major causative agent of adenovirus outbreaks in Gyeonggi province of South Korea during 2009-2011. Continuous surveillance for specific serotypes of adenovirus that can cause outbreaks is important.

Keywords

acute respiratory infection;adenoviruses;hexon;serotyping

Acknowledgement

Supported by : 질병관리본부

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