- Volume 13 Issue 6
DOI QR Code
Therapeutic Profile of T11TS vs. T11TS+MiADMSA: A Hunt for a More Effective Therapeutic Regimen for Arsenic Exposure
- Chaudhuri, Suhnrita (Department of Laboratory Medicine, School of Tropical Medicine) ;
- Acharya, Sagar (Department of Laboratory Medicine, School of Tropical Medicine) ;
- Chatterjee, Sirshendu (Department of Laboratory Medicine, School of Tropical Medicine) ;
- Kumar, Pankaj (Department of Laboratory Medicine, School of Tropical Medicine) ;
- Singh, Manoj Kumar (Department of Laboratory Medicine, School of Tropical Medicine) ;
- Bhattacharya, Debanjan (Department of Biochemistry and Medical Biotechnology, School of Tropical Medicine) ;
- Basu, Anjan Kumar (Division of Pharmacology & Toxicology, Defence Research & Development Establishment) ;
- Dasgupta, Shyamal (Department of Laboratory Medicine, School of Tropical Medicine) ;
- Flora, S.J.S. (Division of Pharmacology & Toxicology, Defence Research & Development Establishment) ;
- Chaudhuri, Swapna (Department of Laboratory Medicine, School of Tropical Medicine)
- Published : 2012.06.30
Arsenic exposure is a serious health hazard worldwide. We have previously established that it may result in immune suppression by upregulating Th2 cytokines while downregulating Th1 cytokines and causing lymphocytic death. Treatment modalities for arsenic poisoning have mainly been restricted to the use of chelating agents in the past. Only recently have combination therapies using a chelating agent in conjunction with other compounds such as anti-oxidants, micronutrients and various plant products, been introduced. In the present study, we used T11TS, a novel immune potentiating glycopeptide alone and in combination with the sulfhydryl-containing chelator, mono-iso-amyl-dimarcaptosuccinic acid (MiADMSA) as a therapeutic regimen to combat arsenic toxicity in a mouse model. Results indicated that Th1 cytokines such as TNF-
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