Expression and Clinical Significance of STAT3, P-STAT3, and VEGF-C in Small Cell Lung Cancer

  • Zhao, Xue (Department of Respiratory Physicians, the Affiliated Hospital of Harbin Medical University) ;
  • Sun, Xian (Department of Respiratory Physicians, the Affiliated Hospital of Harbin Medical University) ;
  • Li, Xiao-Li (Department of Respiratory Physicians, the Affiliated Hospital of Harbin Medical University)
  • Published : 2012.06.30


Objective: To determine STAT3, P-STAT3, and VEGF-C expression levels in small cell lung cancers (SCLCs), and discuss their role and clinical significance in SCLC development. Method: Immunohistochemical methods were applied to 128 cases of SCLC and 40 cases of adjacent normal tissue. Results: The expression levels of STAT3, P-STAT3, and VEGF-C were higher in SCLC than in normal tissue (P<0.05). Pairwise comparisons showed positive correlations with lymph node metastasis, clinical stage, and tumor size (P<0.05). The expression levels were also related with the overall survival rates. Conclusion: STAT3 and VEGF-C play important roles in the development of SCLC, and might be expected to become new targets for SCLC treatment.


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