Quantitative Assessment of the Effects of MMP-2 Polymorphisms on Lung Carcinoma Risk

  • Guo, Xiao-Tong (Department of Thoracic Surgery, the 2nd Affiliated Hospital of Harbin Medical University) ;
  • Wang, Jun-Feng (Department of Thoracic Surgery, the 3rd Affiliated Hospital of Harbin Medical University) ;
  • Zhang, Lin-You (Department of Thoracic Surgery, the 2nd Affiliated Hospital of Harbin Medical University) ;
  • Xu, Guang-Quan (Department of Thoracic Surgery, the 2nd Affiliated Hospital of Harbin Medical University)
  • Published : 2012.06.30


Background: Previous studies assessing associations between matrix metalloproteinase 2 (MMP-2) polymorphisms and lung cancer risk reported conflicting results. A meta-analysis was therefore performed to derive a more precise estimation. Method: Case-control studies assessing associations between MMP-2 C735T and C1306T polymorphisms and lung cancer risk were included. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were estimated. Results: 7 studies with a total of 3,189 lung cancer cases and 3,013 controls were finally included into this meta-analysis. Overall, the MMP-2 C735T polymorphism was associated with lung cancer risk under the homozygote model (CC versus TT: OR =1.44, 95% CI = 1.03-2.02, $I^2$ = 0%), while the MMP-2 C1306T polymorphism also associated demonstrated links with all four models (all P values less than 0.05). Subgroup analyses by race suggested obvious associations between MMP-2 C735T and C1306T polymorphisms and lung cancer risk in Asians but not in Caucasians. There was no evidence for publication bias. Conclusion: Currently available evidence supports teh conclusion that MMP-2 C735T and C1306T polymorphisms influence susceptibility to lung cancer in Asians.


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