Asian Pacific Journal of Cancer Prevention
- Volume 13 Issue 6
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- Pages.2669-2673
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- 2012
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- 1513-7368(pISSN)
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- 1513-7368(eISSN)
DOI QR Code
Continuous Transarterial Infusion Chemotherapy with Gemcitabine and 5-Fluorouracil for Advanced Pancreatic Carcinoma
- Hong, Guo-Bin (The Fifth Affiliated Hospital) ;
- Zhou, Jing-Xing (Department of Radiology, Sun Yat-sen Memorial Hospital, SunYat-sen University) ;
- Sun, Hua-Bin (The Fifth Affiliated Hospital) ;
- Li, Chun-Yang (The Fifth Affiliated Hospital) ;
- Song, Li-Qing (The Fifth Affiliated Hospital)
- Published : 2012.06.30
Abstract
Purpose: Pancreatic carcinoma is one of the most malignant tumors of the alimentary system, with relatively high incidence rates. The purpose of this study was to assess the efficacy and safety of two regimens for advanced pancreatic carcinoma: continuous transarterial infusion versus systemic venous chemotherapy with gemcitabine and 5-fluorouracil. Methods: Of the 48 patients with advanced pancreatic carcinoma receiving chemotherapy with gemcitabine and 5-fluorouracil, 24 received the selective transarterial infusion, and 24 the systemic chemotherapy. For the continuous transarterial infusion group (experimental group), all patients received gemcitabine 1000 mg/
Keywords
Advanced pancreatic carcinoma;clinical benefit rates;survival rate;radiology;interventional;gemcitabine
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References
- Aigner KR, Gailhofer S, Kopp S (1998). Regional versus systemic chemotherapy for advanced pancreatic cancer: a randomized study. Hepatogastroenterology, 45, 1125-9.
- Fu DL, Ni QX, Yu XJ, et al (2002). Regional intra-arterial infusion chemotherapy for pancreatic cancer: an experimental study. Natl Med J Chin, 82, 371-5.
- Hua YP,Liang LJ,Peng BG, et al (2009). Pancreatic head carcinoma:clinical analysis of 189 cases. Hepatobiliary Pancreat Dis Int, 8, 79-84.
- Hwang SI,Kim Ho,Son BH, et al(2009). Surgical palliation of unresectable pancreatic head cancer in elderly patients. World J Gastroenterol, 15, 978-82. https://doi.org/10.3748/wjg.15.978
- Homma H, Doi T, Mezawa S, et al (2000). A novel arterial infusion chemotherapy for the treatment of patients with advanced pancreatic carcinoma after vascular supply distribution via superselective embolization. Cance, 89, 303-13. https://doi.org/10.1002/1097-0142(20000715)89:2<303::AID-CNCR15>3.0.CO;2-1
- Ikeda S, Maeshirok K, Ryu S, et al (2009). Diagnosis of small pancreatic cancer by endoscopic balloon-catheter spot pancreatography: an analysis of 29 patients. Pancreas, 38, 102-13. https://doi.org/10.1097/MPA.0b013e31816909ba
- Jia L, Yuan SZ (2002). Clinical benefit response(CBR):a new index for chemotherapy of pancreatic cancer and its application. Med Recapitulate, 8, 304-5.
- Klauss M, Stiller W, Fritz F, et al (2012). Computed tomography perfusion analysis of pancreatic carcinoma. J Comput Assist Tomogr, 36, 237-42. https://doi.org/10.1097/RCT.0b013e31824a099e
- Miller AB, Hoogstraten B, Staquet M, et al (1981).Reporting results of cancer. Treatment. Cancer, 47, 207-14. https://doi.org/10.1002/1097-0142(19810101)47:1<207::AID-CNCR2820470134>3.0.CO;2-6
- Moore MJ, Hamm J, Dancey J, et al (2003). Comparison of gemcitabine versus the matrix metalloproteinase inhibitor BAY 12-9566 in patients with advanced or metastatic adenocarcinoma of the pancreas: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol, 21, 3296-302. https://doi.org/10.1200/JCO.2003.02.098
- Ouaissi M,Sielezneff I, Pirro N, et al (2008). Pancreatic cancer and pancreaticoduodenectomy in elderly patient: morbidity and mortality are increased. Is it the real life? Hepatogastroenterology, 55, 2242-6.
- Shi HF, Jin ZY, Zhou ZQ, et al (2002). Transarterial infusion chemotherapy with a combination of gemcitabine and 5-fluorouracil in advanced pancreatic carcinoma. Chin J Radiol, 36, 1072-4.
- Tomoo K, Takahiro K, Kiyoshi M, et al (2006). A multicenter randomized controlled trial to evaluate the effect of adjuvant cisplatin and 5-fluorouracil therapy after curative resection in cases of pancreatic cancer. Jpn J Clin Oncol, 36, 159-65. https://doi.org/10.1093/jjco/hyi234
- Tuli R, Surmak A, Reyes J, et a l(2012). Development of a novel rreclinical pancreatic cancer research model: bioluminescence image-guided focal irradiation and tumor monitoring of orthotopic xenografts. Transl Oncol, 5, 77-84. https://doi.org/10.1593/tlo.11316
- Wilkowski R, Thoma M, Bruns C, et al (2006). Chemoradiotherapy with Gemcitabine and continuous 5-Fu in patients with primary inoperable pancreatic cancer. J Pancreas,7(4),349-360.
- Zhou J, Song SD, Li DC, et al (2012). Clinical significance of expression and amplification of the DcR3 gene in pancreatic carcinoma. Aaian Pac J Cancer Prev, 13, 719-24. https://doi.org/10.7314/APJCP.2012.13.2.719
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