- Volume 13 Issue 6
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Outcome of Febrile Neutropenic Patients on Granulocyte Colony Stimulating Factor in a Tertiary Care Hospital
- Osmani, Asif Husain (Section Hematology/Oncology, Department of Medicine, Aga Khan University Hospital) ;
- Ansari, Tayyaba Zehra (Section Hematology/Oncology, Department of Medicine, Aga Khan University Hospital) ;
- Masood, Nehal (Section Hematology/Oncology, Department of Medicine, Aga Khan University Hospital) ;
- Ahmed, Bilal (Section Hematology/Oncology, Department of Medicine, Aga Khan University Hospital)
- Published : 2012.06.30
Introduction: Febrile neutropenia is a relatively frequent event in cancer patients treated with chemotherapy and improvement in absolute neutrophil count (ANC) has been linked directly to improved outcome. Evaluation of granulocyte colony stimulating factors (GCSFs) for treatment has shown reduced incidences of episodes of prolonged neutropenia and protracted hospitalization. To determine absolute neutrophil counts with GCSF in febrile neutropenic cancer patients admitted to a tertiary care centre and to co-relate the improvement in ANC with mortality and hospital discharge. Methods: A prospective cross sectional study was carried at an oncology ward at Aga Khan University hospital from January 2010 to June 2011. All adult patients who were admitted and treated with GCSF for chemotherapy induced febrile neutropenia were included. Multivariable regression was conducted to identify the factors related with poor outcomes. Results: A total of 131 patients with febrile neutropenia were identified with mean age of 43.2 (18-85) years, 79 (60%) being
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