- Volume 13 Issue 6
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MTHFR C667T Polymorphism Association with Lung Cancer Risk in Henan Province: A Case-control Study
- Cheng, Zhe (Department of Respiratory Medicine, The First Affiliated Hospital of Zhengzhou University, Institute of Clinical Medical Research of Henan Universities) ;
- Wang, Wei (Department of Occupational Health and Toxicology, School of Public Health, Zhengzhou University) ;
- Dai, Ling-Ling (Department of Respiratory Medicine, The First Affiliated Hospital of Zhengzhou University, Institute of Clinical Medical Research of Henan Universities) ;
- Kang, Yan (Department of Respiratory Medicine, The First Affiliated Hospital of Zhengzhou University, Institute of Clinical Medical Research of Henan Universities)
- Published : 2012.06.30
The current study was performed to assess any association between the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and risk of lung cancer in Henan province. This case-control study involved94 patients with newly histological confirmed lung cancer and 78 healthy controls. Genotyping was achieved with peripheral blood lymphocytes DNA and association of the polymorphism with risk of lung cancer was estimated by unconditional logistic regression analysis. The frequencies of the MTHFR 667TT genotype were 37.2% in cases compared with 23.1% in controls (
MTHFR;mononucleotide polymorphism;lung cancer;susceptibility
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