- Volume 13 Issue 6
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Residential Radon and Lung Cancer Risk: An Updated Meta-analysis of Case-control Studies
- Zhang, Zeng-Li (Department of Health Toxicology, School of Public Health of Soochow University) ;
- Sun, Jing (Department of Health Toxicology, School of Public Health of Soochow University) ;
- Dong, Jia-Yi (Department of Nutrition and Food Hygiene, School of Public Health of Soochow University) ;
- Tian, Hai-Lin (Department of Labor Hygiene and Environmental Health, School of Public Health of Soochow University) ;
- Xue, Lian (Department of Labor Hygiene and Environmental Health, School of Public Health of Soochow University) ;
- Qin, Li-Qiang (Department of Nutrition and Food Hygiene, School of Public Health of Soochow University) ;
- Tong, Jian (Department of Health Toxicology, School of Public Health of Soochow University)
- Published : 2012.06.30
Background: Numbers of epidemiological studies assessing residential radon exposure and risk of lung cancer have yielded inconsistent results. Methods: We therefore performed a meta-analysis of relevant published case-control studies searched in the PubMed database through July 2011 to examine the association. The combined odds ratio (OR) were calculated using fixed- or random-effects models. Subgroup and dose-response analyses were also performed. Results: We identified 22 case-control studies of residential radon and lung cancer risk involving 13,380 cases and 21,102 controls. The combined OR of lung cancer for the highest with the lowest exposure was 1.29 (95% CI 1.10-1.51). Dose-response analysis showed that every 100 Bq/
Residential radon;lung cancer;radiation;case-control study;meta-analysis
Supported by : National Natural Science Foundation of China
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