- Volume 32 Issue 4
DOI QR Code
Probiotics Inhibit Lipopolysaccharide-Induced Interleukin-8 Secretion from Intestinal Epithelial Cells
- Oh, Hyun-Wook (Division of Food Bioscience and Technology, Korea University) ;
- Jeun, Gi-Hoon (Division of Food Bioscience and Technology, Korea University) ;
- Lee, Jin (Division of Food Bioscience and Technology, Korea University) ;
- Chun, Tae-Hoon (Division of Biotechnology, Korea University) ;
- Kim, Sae-Hun (Division of Food Bioscience and Technology, Korea University)
- Received : 2012.01.26
- Accepted : 2012.07.24
- Published : 2012.08.31
It has been suggested that probiotics could be useful for the prevention of symptomatic relapse in patients with inflammatory bowel disease (IBD). Interleukin (IL)-8 has been well recognized as one of the pro-inflammatory cytokines that could trigger inflammation and epithelial barrier dysfunction. In this study, the anti-inflammatory effects of probiotics were investigated using a human epithelial cell line (HT-29). Probiotics from infant feces and kimchi were tested for their cytotoxicity and effects on adhesion to epithelial cells. The present results show that seven strains could form 70 % adhesion on HT-29. The probiotics used in this study did not affect HT-29 cell viability. To screen anti-inflammatory lactic acid bacteria, HT-29 cells were pretreated with live and heat-killed probiotics, and lipopolysaccharide (LPS) (
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