Total Polyphenols, Total Flavonoid Contents, and Antioxidant Activity of Korean Natural and Medicinal Plants

자생식물과 생약자원 추출물의 폴리페놀, 플라보노이드 함량 및 항산화 활성 탐색

  • Kim, Eun-Jin (Department of Food and Nutrition, Graduate School, Chung-Ang University) ;
  • Choi, Joo-Yeon (Department of Food and Nutrition, Graduate School, Chung-Ang University) ;
  • Yu, Mi-Ri (Department of Food and Nutrition, Graduate School, Chung-Ang University) ;
  • Kim, Mi-Young (Department of Food and Nutrition, Graduate School, Chung-Ang University) ;
  • Lee, Sang-Hyun (Department of Integrative Plant Science, School of Bioresource and Bioscience, Chung-Ang University) ;
  • Lee, Bog-Hieu (Department of Food and Nutrition, Graduate School, Chung-Ang University)
  • 김은진 (중앙대학교 대학원 식품영양학과) ;
  • 최주연 (중앙대학교 대학원 식품영양학과) ;
  • 유미리 (중앙대학교 대학원 식품영양학과) ;
  • 김미영 (중앙대학교 대학원 식품영양학과) ;
  • 이상현 (중앙대학교 생명자원공학부 식물시스템과학전공) ;
  • 이복희 (중앙대학교 대학원 식품영양학과)
  • Received : 2012.02.02
  • Accepted : 2012.03.06
  • Published : 2012.06.30


The purpose of this study was to investigate total polyphenols, total flavonoid, and DPPH radical scavenging activity in 26 species of Korean natural plants and 14 species of medicinal plant extracts. The plant containing the highest total polyphenols and total flavonoids were Plantago asiatica, and Lespedeza cuneata G. Don, respectively. The content of polyphenols and flavonoids in natural plants was the highest in Lespedeza cuneata G. Don, which also demonstrated high DPPH radical scavenging activity. In medicinal plant extract, Saururus chinensis (Lour.) Baill and Artemisiae Asiaticae Herba had the highest level of total polyphenols (194.60 and 203.92 mg/g extract, respectively) and DPPH radical scavenging activity. Diospyros kaki Thunb and Dryopteris crassirhizoma did not contain high levels of total polyphenols (112.98, 121.46 mg/g extract, respectively) and flavonoids (46.10, 58.69 mg/g extract respectively), but DPPH radical scavenging activity was relatively high. Further study regarding plants that exhibit higher total polyphenols, total flavonoid, and DPPH radical scavenging activity is needed.


natural plants;medicinal plants;antioxidant activity;polyphenols;flavonoid


Supported by : 한국연구재단


  1. Lee SO, Lee HJ, Yu MH, Im HG, Lee IS. Total polyphenol contents and antioxidant activities of methanol extracts from vegetables produced in Ullung island. Korean J. Food Sci. Technol. 37: 233-240 (2005)
  2. Joo EY, Park CS. Antioxidative and fibrinolytic activity of extracts from soybean and cheonggukjang (fermented soybeans) prepared from a black soybean cultivar. Korean J. Food Preserv. 17: 874-880 (2010)
  3. Canadanovic-Brunet JM, Djilas SM, Cetkovic GS, Tumbas VT. Free-radical scavenging activity of wormwood(Artemisia absinthium L.) extracts. J. Sci. Food Agr. 85: 265-272 (2005)
  4. Lee JH, Park AR, Choi DW, Kim JD, Kim JC, Ahn JH, Lee HY, Choe M, Choi KP, Shin IC, Park HJ. Analysis of chemical compositions and electron-donating ability of 4 Korean wild sannamuls. Korean J. Medicinal Crop. 19: 111-116 (2011)
  5. Kim HK, Kwon YJ, Kim KH, Jeong YH. Changes of total polyphenol content and electron donating ability of Aster glehni extracts with different microwave-assisted extraction conditions. Korean J. Food Sci. Technol. 32: 1022-1028 (2000)
  6. Kim HJ, Lee JW, Kim YD. Antimicrobiral activity and antioxidant effect of Curcuma longa, Curcuma aromatica, and Curcuma zedoaria. Korean J. Food Preserv. 18: 219-225 (2011)
  7. Shon HK, Lee YS, Park YH, Kim MJ, Lee KA. Physico-chemical properties of gugija (Lycii fructus) extracts. Korean J. Food Cookery Sci. 24: 905-911 (2008)
  8. Chung HY, Sung B, Jung KJ, Zou Y, Yu BP. The molecular inflammatory process in aging. Antioxid. Redox Sign. 8: 572-581 (2006)
  9. Lee SH, Hong LJ, Park HG, Ju SS, Kim GT. Functional characteristics from the barley leaves and its antioxidant mixture. J. Korean Soc. Agric. Chem. Biotechnol. 46: 333-337 (2003)
  10. Christen Y. Oxidative stress and Alzheimer disease. Am. J. Clin. Nutr. 71: 621-629 (2000)
  11. Nunomura A, Castellani R, Zhu X, Moreira P, Perry G, Smith M. Involvement of oxidative stress in Alzheimer disease. J. Neuropathol. Exp. Neur. 65: 631-641 (2006)
  12. Van-Gaal L, Mertens I, De-Block C. Mechanisms linking obesity with cardiovascular disease. Nature 444: 875-880 (2006)
  13. Block G, Langseth L. Antioxidant vitamins and disease prevention. Food Technol. 48: 80-85 (1994)
  14. Urquiaga I, Leighton F. Plant polyphenol antioxidants and oxidative stress.Biol. Res. 33: 55-64 (2000)
  15. Dai J, Mumper RJ. Plant phenolics: Extraction, analysis, and their antioxidant and anticancer properties. Molecules 15: 7313-7352 (2010)
  16. Lu Y, Foo LY. Antioxidant and radical scavenging activities of polyphenols from apple pomace. Food Chem. 68: 81-85 (2000)
  17. Cha JY, Kim HJ, Chung CH, Cho YS. Antioxidative activities and contents of polyphenolic compound of Cudrania tricuspidata. J. Korean Soc. Food Sci. Nutr. 28: 1310-1315 (1999)
  18. Hetog MGL, Hollman PCH, Van de Putte B. Content of potentially anticarcinogenic flavonoids of tea infusions, wines and fruit juice. J. Agr. Food Chem. 41: 1242-1246 (1993)
  19. Tsao R. Chemistry and biochemistry of dietary polyphenols. Nutrients 2: 1231-1246 (2010)
  20. Heim KE, Tagliaferro AR, Bobilya DJ. Flavonoid antioxidants: Chemistry, metabolism, and structure-activity relationships. J. Nutr. Biochem. 13: 572-584 (2002)
  21. Williams RJ, Spencer JP, Rice-Evans C. Flavonoids: Antioxidants or signaling molecules? Free Radic. Bio. Med. 36: 838-849 (2004)
  22. Sohn HY, Ryu HY, Jang YJ, Jang HS, Park YM, Kim SY. Evaluation of antimicrobial, antithrombin, and antioxidant activity of aerial part of Saxifraga stolonifera. Korean J. Microbiol. Biotechnol. 36: 195-200 (2008)
  23. Ryu MJ, Lee SY, Park Y, Yang YK. Antioxidative activities and antifungal effect against Malassezia furfur in the extracts from 6 spp. medicinal plants. J. Korean Soc. Cosm. 16: 120-128 (2010)
  24. Kim JY, Lee JY, Lee WY, Yi Y, Lim Y. Anti-oxidant property and inhibition of melanin synthesis of eight plant extracts Korean J. Microbiol. Biotechnol. 38: 414-419 (2010)
  25. Korean Environment Corporation. Accessed Jan. 9, 2012.
  26. Cho IS, Han YH, Lee GY, Park KY. Search for medicinal plants on improvable effect of intestinal microflora. Korean J. Medicinal Crop. Sci. 15: 26-29 (2007)

Cited by

  1. The Change of Free Sugar, Hesperidine, Naringin, Flavonoid Contents and Antihypertensive Activities of Yuza Variety according to Harvest Date vol.27, pp.6, 2014,
  2. Antioxidant Capacity of Crude Extract and Its Solvent Fractions of Arctic Terrestrial Plant Ranunculus heperporeus vol.38, pp.3, 2016,
  3. Comparative Study of Biological Activities at Different Harvesting Times and New Varieties for Highland Culture of Gom-chwi vol.28, pp.4, 2015,
  4. A Study of the Antioxidant Activities and Whitening Activities of Areca semen Extracts as Cosmetic Ingredient vol.41, pp.3, 2015,
  5. Comparison of antioxidant, α-glucosidase inhibition and anti-inflammatory activities of the leaf and root extracts ofSmilax chinaL. vol.46, pp.4, 2013,
  6. Protective effect of Acer okamotoanum from oxidative stress in C6 glial cells vol.60, pp.2, 2017,
  7. Antioxidant Activity of 11 Species in Korean Native Forest Plants vol.28, pp.6, 2015,
  8. Effects of Zizyphi Spinosae Extract on Cisplatin and t-Butylhydroperoxide Induced Acute Renal Failure in Rabbits vol.24, pp.7, 2014,
  9. Effects of White Habiscus syriacus L. Flower Extracts on Antioxidant Activity and Bone Resorption Inhibition vol.23, pp.3, 2015,
  10. A Verification of Cosmetic Effect about Anti-oxidant and Anti-wrinkle of 11 Native Plants vol.26, pp.7, 2016,
  11. Composition and Antioxidant Activity of Dried Laver, Dolgim vol.45, pp.4, 2013,
  12. Saccharification of Fagopyrum esculentum by Amylase Treatments increases Phenolic Compound Content and Antioxidant Activity vol.25, pp.1, 2015,
  13. Studies on Bioactive Substances and Antioxidant Activities of Marine Algae from Jeju Island vol.8, pp.1, 2016,
  14. Effect of Drying and Extraction Methods on Antioxidant Activity of Gnaphalium affine D. DON vol.44, pp.5, 2015,
  15. Effects of Die Temperature and CO2Injection on Physical Properties and Antioxidant Activity of Extruded Rice with Tomato Flour vol.44, pp.6, 2015,
  16. Quality Deterioration Suppressing Effects of pH Regulators during Heat Treatment of Concentrated Blueberry Puree vol.32, pp.5, 2016,
  17. Flavonoids composition and antioxidant activity of by-products of five orange cultivars during maturation vol.23, pp.7, 2016,
  18. A Study on the Utilization of Dendropanax morbifera Lev. Leaf Extract for Material of Functional Cosmetics and Hair Growth Products vol.14, pp.3, 2016,
  19. Study of Lipoprotein Lipase Inhibitory Activity of Anti-obesity Herb Extracts vol.47, pp.2, 2015,
  20. Antioxidant Activity of Different Parts of Lespedeza bicolor and Isolation of Antioxidant Compound vol.44, pp.6, 2012,
  21. Cultivation characteristics and flavonoid contents of wormwood (Artemisia montana Pamp.) vol.02, pp.04, 2013,
  22. Influence of extraction conditions on antioxidant activities and catechin content from bark of Ulmus pumila L. vol.59, pp.3, 2016,
  23. Phytochemical Contents and Antioxidant Activities of Opuntia ficus-indica var. saboten vol.29, pp.5, 2016,
  24. Biological Activity and Chemical Characteristics of Cordyceps militaris Powder Fermented by Several Microscopic Organisms vol.25, pp.2, 2015,
  25. Improving effect of Artemisiae Capillaris Herba extract in reflux esophagitis rats vol.31, pp.6, 2016,
  26. Analysis on the Components and Safety Evaluation of Abeliophyllum distichum Nakai Leaves and Stems vol.40, pp.3, 2014,
  27. Antioxidative ability of ethanol extract from the leaves of Leucaena leucocephala (Lam.) de Wit vol.60, pp.2, 2017,
  28. Antioxidative Effects of Extracts from Different Parts of Epimedium koreanum Nakai vol.45, pp.2, 2016,
  29. Vitamin C, Total Polyphenol, Flavonoid Contents and Antioxidant Capacity of Several Fruit Peels vol.44, pp.5, 2012,
  30. Nutritional Compositions and Physiological Activities of Chungbuk New Mulberry Cultivar 'Cheongsu' vol.29, pp.1, 2016,
  31. A study of the lipoprotein lipase inhibitory mechanism ofPoncirus trifoliatawater extracts vol.48, pp.1, 2015,
  32. Antioxidant activity and inhibition activity against α-amylase and α-glucosidase of Smilax China L. vol.21, pp.2, 2014,
  33. Bioactive Components and Volatile Compounds According to Illite Addition in Saururus chinensis Baill Cultivation vol.22, pp.3, 2014,
  34. Anti-Oxidant Activity and Anti-Inflammatory Effects of Spiraea fritschiana Schneid Extract vol.24, pp.1, 2016,
  35. Comparison of Total Phenol, Flavonoid Contents, and Antioxidant Activities of Orostachys japonicus A. Berger Extracts vol.25, pp.5, 2016,
  36. Usefulness Evaluation of Water Extracts of Edible Plants as Compounds for the Natural Cosmetics Based on Present or Absent of Anthocyanin vol.14, pp.4, 2016,
  37. Antioxidant and Inflammatory Mediators Regulation Effects of the Roots of Opuntia humifusa vol.57, pp.1, 2014,
  38. Antioxidative Activity and Protein Expression Effects of the Extracts from Cinnamomum camphora on the Hair-growth Relevant Factors vol.14, pp.1, 2016,
  39. Nutritional composition and functionality of mixed cereals powder vol.21, pp.3, 2014,
  40. Platycarya strobilacea S. et Z. Extract Has a High Antioxidant Capacity and Exhibits Hair Growth-promoting Effects in Male C57BL/6 Mice vol.19, pp.3, 2014,
  41. subtropical fruits vol.22, pp.4, 2015,
  42. Use of oriental melon peel extracts to maintain the quality of Agaricus bisporus during its storage vol.21, pp.4, 2014,
  43. Comparison of Plant Growth, Dormancy Breaking, Yield, and Biological Activities of Extracts in Four Asparagus Cultivars vol.33, pp.5, 2015,
  44. Comparison of Antioxidant Activities of Extruded Rice with Vegetables by Cold and Conventional Extrusion vol.44, pp.8, 2015,
  45. Antioxidant and Antiproliferative Activity of Extracts from Water Chestnut (Trapa japonica Flerow) vol.24, pp.1, 2016,
  46. Effect of Rudbeckia laciniata Extract on Physiological Activity of HaCaT Cells vol.29, pp.3, 2016,
  47. Proximate Compositions and Biological Activities of Lactuca indica L. Seonhyang and Wild Species Depending on Harvesting Time vol.44, pp.3, 2015,
  48. Stability of Danggwisu-san (Dangguixu-san) Water Extract, a Herbal Medicine, Under Various Storage Conditions vol.26, pp.4, 2016,
  49. Flavonoid and Phenol Contents and Antioxidant Effect of Wine By-product Extracts vol.26, pp.8, 2016,
  50. In Vitro Antioxidative Activity and Polyphenol and Tocopherol Contents of Bugak with Lotus Root, Dried Laver, or Perilla Leaf vol.30, pp.6, 2014,
  51. Hair growth-promoting effect of Geranium sibiricum extract in human dermal papilla cells and C57BL/6 mice vol.17, pp.1, 2017,
  52. Screening of DPPH radical scavenging and antimicrobial activity of extracts from local some native plants vol.21, pp.4, 2014,
  53. Quality Characteristics and Antioxidant Activity of Aronia (Aronia melanocarpa) makgeolli prepared with the Additive Methods vol.28, pp.4, 2015,
  54. Applicability of Lindera obtusiloba Flower Extracts as Cosmetic Ingredients vol.15, pp.2, 2017,
  55. Effect of Extraction Solvent on the Physiological Properties of Korean Pear Peel (Pyrus pyrifolia cv. Niitaka) vol.47, pp.2, 2015,
  56. Effects of Complex Carbohydrase Treatment on Physiological Activities of Pear Peel and Core vol.43, pp.3, 2014,
  57. Antioxidant Activities of Medicinal Plant Extracts vol.42, pp.4, 2013,
  58. Antioxidant and Anti-inflammatory Activity of Medicinal Herbs Composites vol.49, pp.5, 2015,
  59. Physicochemical Characteristics and Antioxidant Effects of Red Mustard (Brassica juncea L.) Leaf Using Different Drying Methods vol.28, pp.4, 2017,
  60. Antioxidant Activity of Major Cultivars Prunus mume in Korea vol.26, pp.3, 2018,
  61. Assessment of Nutritional Components, Antioxidant Contents and Physiological Activity of Purple Corn Husk and Cob Extracts vol.33, pp.6, 2018,