Determination of Enantiopurity of Chiral Epoxides by Vibrational Circular Dichroism Spectroscopy

진동 원편광 이색성 분광기를 사용한 키랄 에폭사이드의 광학순도 분석

  • Lee, Joo-Hyun (Department of Chemical Engineering, Inha University) ;
  • Lee, Choong-Young (Department of Chemical Environmental Technology, Inha Technical College) ;
  • Kim, Geon-Joong (Department of Chemical Engineering, Inha University)
  • 이주현 (인하대학교 생명화학공학부) ;
  • 이충영 (인하공업전문대학 화공환경과) ;
  • 김건중 (인하대학교 생명화학공학부)
  • Published : 2012.12.10

Abstract

In this work, vibrational circular dichroism (VCD) technique was applied for the determination of %EE of chiral compounds. It may provide an easy way to determine the %EE with a proper accuracy within 2% error ranges as well as the absolute configuration of enantiomers. We demonstrated herein a flow cell VCD (FT-VCD) technique for time-dependent %EE measurements. The simultaneous monitoring of the mole fraction and %EE for two chiral species (epichlorohydrin and glycidol mixture) in the mixture was shown to be successful without any further separation steps. Thus, we demonstrate that FT-VCD is an appropriate analytical tool to monitor the kinetics of reactions involving chiral molecules. FT-VCD also provides a convenient nondestructive approach for the time dependent determination of the optical purity of individual components in a reaction mixture containing chiral molecules.

Keywords

vibrational circular dichroism;absolute configuration;enantiomer;chirality;epichlorohydrin

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