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Type-Specific Incidence and Persistence of HPV Infection among Young Women: A Prospective Study in North India

  • Datta, Palika (Department of Biochemistry, All India Institute of Medical Sciences) ;
  • Bhatla, Neerja (Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences) ;
  • Pandey, R.M. (Department of Biostatistics, All India Institute of Medical Sciences) ;
  • Dar, Lalit (Department of Microbiology, All India Institute of Medical Sciences) ;
  • Patro, A. Rajkumar (Department of Microbiology, All India Institute of Medical Sciences) ;
  • Vasisht, Shachi (Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences) ;
  • Kriplani, Alka (Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences) ;
  • Singh, Neeta (Department of Biochemistry, All India Institute of Medical Sciences)
  • Published : 2012.03.31

Abstract

Background: Infections with human papillomavirus (HPV) are highly prevalent among sexually active young women in India. However, not much is known about the incidence of type-specific human papillomavirus (HPV) infections and their patterns of persistence, especially in the Indian context. Objective: The objective of this study was to evaluate the rate of acquisition and persistence of HPV types in young women. Methods: Women residing in an urban slum in Delhi (n=1300) were followed for 24 months at 6 monthly intervals. Exfoliated cervical cells collected at each visit were tested for the presence of HPV DNA. Genotyping was performed using the reverse line blot assay. Results: The incidence rate for any HPV type was calculated to be 5 per 1000 women-months. Among high risk HPV types, HPV16 had the highest incidence rate followed by HPV59, HPV52 and HPV18, i.e., 3.0, 0.58, 0.41 and 0.35 women per 1000 women-months respectively. The persistence rate was higher for high-risk than low-risk HPV types. Among low-risk types, HPV42, HPV62, HPV84 and HPV89 were found to persist. Whereas almost all high risk types showed persistence, the highest rate was found in women with HPV types 16, 45, 67, 31, 51 and 59. The persistence rate for HPV16 infection was 45 per 1000 women-months. Conclusion: Incident HPV infections and high risk HPV type-specific persistence were found to be high in our study population of young married women. Understanding the patterns of HPV infection may help plan appropriate strategies for prevention programs including vaccination and screening.

References

  1. Ahdieh L, Klein RS, Burk R, et al (2001). Prevalence, incidence, and type-specific persistence of human papillomavirus in human immunodeficiency virus (HIV)-positive and HIVnegative women. J Infect Dis, 184, 682-90. https://doi.org/10.1086/323081
  2. Bosch FX, Lorincz A, Munoz N, Meijer CJ, Shah KV (2002). The causal relation between human papillomavirus and cervical cancer. J Clin Pathol, 54, 244-5
  3. Brown DR, Shew ML, Qadadri B, et al (2005). A longitudinal study of genital human papillomavirus infection in a cohort of closely followed adolescent women. J Infect Dis, 191, 182-2. https://doi.org/10.1086/426867
  4. Castle PE, Schiffman M, Herrero R, et al (2005). A prospective study of age trends in cervical human papillomavirus acquisition and persistence in Guanacaste, Costa Rica. J Infect Dis, 191, 1808-6. https://doi.org/10.1086/428779
  5. Datta P, Bhatla N, Dar L, et al (2010). Prevalence of human papillomavirus infection among young women in North India. Cancer Epidemiol, 34, 157-1. https://doi.org/10.1016/j.canep.2009.12.016
  6. Franco EL, Villa LL, Sobrinho JP, et al (1999). Epidemiology of acquisition and clearance of cervical human papillomavirus infection in women from a high-risk area for cervical cancer. J Infect Dis, 180, 1415-3. https://doi.org/10.1086/315086
  7. Giuliano AR, Harris R, Sedjo RL, et al (2002). Incidence, prevalence, and clearance of type-specific human papillomavirus infections: the Young Women's Health Study. J Infect Dis, 186, 462-9. https://doi.org/10.1086/341782
  8. Goodman MT, Shvetsov YB, McDuffie K, et al (2008). Prevalence, acquisition, and clearance of cervical human papillomavirus infection among women with normal cytology: Hawaii Human Papillomavirus Cohort Study. Cancer Res, 168, 8813-4.
  9. Ho GY, Bierman R, Beardsley L, Chang CJ, Burk RD (1998). Natural history of cervicovaginal papillomavirus infection in young women. N Engl J Med, 338, 423-8. https://doi.org/10.1056/NEJM199802123380703
  10. Molano M, Van Den Brule A, Plummer M, et al (2003). Determinants of clearance of human papillomavirus infections in Colombian women with normal cytology: a population-based, 5-year follow-up study. Am J Epidemiol , 158, 486-4. https://doi.org/10.1093/aje/kwg171
  11. Moscicki AB, Hills N, Shiboski S, et al (2001). Risks for incident human papillomavirus infection and low-grade squamous intraepithelial lesion development in young females. JAMA , 285, 2995-1. https://doi.org/10.1001/jama.285.23.2995
  12. Moscicki AB, Schiffman M, Kjaer S, Villa LL (2006). Chapter 5: updating the natural history of HPV and anogenital cancer. Vaccine, 24, 42-1.
  13. Moscicki AB, Shiboski S, Broering J, et al (1998). The natural history of human papillomavirus infection as measured by repeated DNA testing in adolescent and young women. J Pediatrics, 132, 277-4. https://doi.org/10.1016/S0022-3476(98)70445-7
  14. Muñoz N, Méndez F, Posso H, et al (2004). Incidence, duration, and determinants of cervical human papillomavirus infection in a cohort of Colombian women with normal cytological results. J Infect Dis, 190, 2077-7. https://doi.org/10.1086/425907
  15. Richardson H, Kelsall G, Tellier P, et al (2003). The natural history of type-specific human papillomavirus infections in female university students. Cancer Epidemiol Biomarkers Prev, 12, 485-0.
  16. Sellors JW, Karwalajtys TL, Kaczorowski J, et al (2003). Incidence, clearance and predictors of human papillomavirus infection in women. CMAJ, 168, 421-5.
  17. Trottier H, Mahmud S, Prado JC, et al (2008). Type-specific duration of human papillomavirus infection: implications for human papillomavirus screening and vaccination. J Infect Dis, 197, 1436-7. https://doi.org/10.1086/587698
  18. Walboomers JM, Jacobs MU, Manos MM, et al (1999). HPV is necessary cause of invasive cervical cancer worldwide. J Pathol, 189, 12-9. https://doi.org/10.1002/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F
  19. Winer RL, Lee SK, Hughes JP, et al (2003). Genital human papillomavirus infection: incidence and risk factors in a cohort of female university students. Am J Epidemiol, 157, 218-6. https://doi.org/10.1093/aje/kwf180
  20. Woodman CB, Collins S, Winter H, et al (2001). Natural history of cervical human papillomavirus infection in young women: a longitudinal cohort study. Lancet, 357, 1831-6. https://doi.org/10.1016/S0140-6736(00)04956-4
  21. Zur Hausen H (2002). Papillomaviruses and cancer: from basic studies to clinical application. Nat Rev Cancer, 2, 342-50. https://doi.org/10.1038/nrc798

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