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Microwave Ablation Treatment of Liver Cancer with a 2,450-MHz Cooled-shaft Antenna: Pilot Study on Safety and Efficacy

  • Jiao, De-Chao (Department of interventional Radiology, The First Affiliated Hospital of Zhengzhou University) ;
  • Zhou, Qi (Department of Hepatobiliary Surgery, The First Affiliated Hospital of SunYat-sen University) ;
  • Han, Xin-Wei (Department of interventional Radiology, The First Affiliated Hospital of Zhengzhou University) ;
  • Wang, Ya-Feng (Department of Hepatobiliary Surgery, The First Affiliated Hospital of SunYat-sen University) ;
  • Wu, Gang (Department of interventional Radiology, The First Affiliated Hospital of Zhengzhou University) ;
  • Ren, Jian-Zhuang (Department of interventional Radiology, The First Affiliated Hospital of Zhengzhou University) ;
  • Wang, Yan-Li (Department of interventional Radiology, The First Affiliated Hospital of Zhengzhou University) ;
  • Ding, Peng-Xu (Department of interventional Radiology, The First Affiliated Hospital of Zhengzhou University) ;
  • Ma, Ji (Department of interventional Radiology, The First Affiliated Hospital of Zhengzhou University) ;
  • Fu, Ming-Ti (Department of interventional Radiology, The First Affiliated Hospital of Zhengzhou University)
  • Published : 2012.02.29

Abstract

To evaluate efficacy of microwave ablation in a primary clinical study, sixty patients (44 men, 16 women; mean age 53 years) with 96, 1-8 cm (mean $3.20{\pm}0.17$ cm) liver cancers were treated with 2,450-MHz internally cooled-shaft antenna. Complete ablation (CA) and local tumor progression (LTP) rates as well as complications were determined. CA rates in small (< 3.0 cm), intermediate (3.1-5.0 cm) and large (5.1-8.0 cm) liver cancers were 96.4% (54/56), 92.3% (24/26) and 78.6% (11/14), respectively. During a mean follow-up period of $17.17{\pm}6.52$ months, LTP occurred in five (5.21%) treated cases. There was no significant difference in the CA and LTP rates between the HCC and liver metastasis patient subgroups (P<0.05). Microwave ablation provides a reliable, efficient, and safe technique to perform hepatic tumor ablation.

Keywords

Liver cancer;microwave ablation;clinical study;China

References

  1. Abe T, Shinzawa H, Wakabayashi H, et al (2000). Value of laparoscopic microwave coagulation therapy for hepatocellular carcinoma in relation to tumor size and location. Endoscopy, 32, 598-603. https://doi.org/10.1055/s-2000-9016
  2. Cabassa P, Donato F, Simeone F, Grazioli L, Romanini L (2006). Radiofrequency ablation of hepatocellular carcinoma: longterm experience with expandable needle electrodes. AJR Am J Roentgenol, 186, S316-21. https://doi.org/10.2214/AJR.05.0243
  3. Chen MH, Yang W, Yan K, et al (2004). Large liver tumors: protocol for radiofrequency ablation and its clinical application in 110 patients- mathematic model, over-lapping mode, and electrode placement process. Radiology, 232, 260-71. https://doi.org/10.1148/radiol.2321030821
  4. Clasen S, Schmidt D, Boss A, et al (2006). Multipolar radiofrequency ablation with internally cooled electrodes: experimental study in ex vivo bovine liver with mathematic modeling. Radiology, 238, 881-90. https://doi.org/10.1148/radiol.2382050571
  5. Dib RE, Touma NJ, Kapoor A (2009). Review of the efficacy and safety of radiofrequency ablation for the treatment of small renal masses. Can Urol Assoc J, 3, 143-9.
  6. Dong BW, Liang P, Yu XL, et al (1998). Sonographically guided microwave coagulation treatment of liver cancer: an experimental and clinical study. AJR Am J Roentgenol, 171, 449-54. https://doi.org/10.2214/ajr.171.2.9694473
  7. Dong BW, Liang P, Yu X,et al (2003). Percutaneous sonographically guided microwave coagulation therapy for hepatocellular carcinoma: results in 234 patients. AJR Am J Roentgenol, 180, 1547-55. https://doi.org/10.2214/ajr.180.6.1801547
  8. English NJ, MacElroy JM(2003). Molecular dynamics simulations of microwave heating of water. J Chem Phys, 118, 1589-1592. https://doi.org/10.1063/1.1538595
  9. Goldberg SN, Ahmed M, Gazelle GS, et al (2001). Radiofrequency thermal ablation with NaCl solution injection: effect of electrical conductivity on tissue heating and coagulation-phantom and porcine liver study. Radiology, 219, 157-65. https://doi.org/10.1148/radiology.219.1.r01ap27157
  10. Goldberg SN, Gazelle GS, Mueller PR (2000). Thermal ablation therapy for focal malignancy: a unified approach to underlying principles, techniques, and diagnostic imaging guidance. Am J Roentgenol, 174, 323-31. https://doi.org/10.2214/ajr.174.2.1740323
  11. Hadjicostas P, Malakounides N, Varianos C, et al (2006). Radiofrequency ablation in pancreatic cancer. HPB (Oxford), 8, 61-4. https://doi.org/10.1080/13651820500466673
  12. Hines-Peralta AU, Pirani N, Cleqq P, et al (2006). Microwave ablation: results with a 2.45-GHz applicator in ex vivo bovine and in vivo porcine liver. Radiology, 230, 94-102.
  13. Imoto S, Wada N, Sakemura N, Hasebe T, Murata Y (2009). Feasibility study on radiofrequency ablation followed by partial mastectomy for stage I breast cancer patients. Breast, 18, 130-4. https://doi.org/10.1016/j.breast.2009.02.008
  14. Lencioni R, Cioni D, Crocetti L, et al (2005). Earlystage hepatocellular carcinoma in patients with cirrhosis: longterm results of percutaneous image-guided radiofrequency ablation. Radiology, 234, 961-7. https://doi.org/10.1148/radiol.2343040350
  15. Liang P, Dong B, Yu X, et al (2003). Prognostic factors for percutaneous microwave coagulation therapy of hepatic metastases. AJR Am J Roentgenol, 181, 1319-25. https://doi.org/10.2214/ajr.181.5.1811319
  16. Liang P, Dong B, Yu X, et al (2005). Prognostic factors for survival inpatients with hepatocellular carcinoma after percutaneous microwave ablation. Radiology, 181, 299-307.
  17. Lu MD, Chen JW, Xie XY, et al (2001). Hepatocellular carcinoma: US-guided percutaneous microwave coagulation therapy. Radiology, 221, 167-72. https://doi.org/10.1148/radiol.2211001783
  18. Martin RC, Scoggins CR, McMasters KM (2007). Mcirowave hepatic ablation: initial experience of safety and efficacy. J of Surg Oncol, 96, 481-6. https://doi.org/10.1002/jso.20750
  19. Ng KK, Lam CM, Poon RT, et al (2005). Porcine liver: morphologic characteristics and cell viability at experimental radiofrequency ablation with internally cooled electrodes. Radiology, 235, 478-86. https://doi.org/10.1148/radiol.2352040425
  20. Shibata T, Maetani Y, Isoda H, Hiraoka M (2006). Radiofrequency ablation for small hepatocellular carcinoma: prospective comparison of internally cooled electrode and expandable electrode. Radiology, 238, 346-53. https://doi.org/10.1148/radiol.2381041848
  21. Ohno T, Kawano K, Sasaki A, et al (2001). Expansion of an ablated site and induction of apoptosis after microwave coagulation therapy in rat liver. J Hepatobiliary Pancreat Surg, 8, 360-6. https://doi.org/10.1007/s005340170009
  22. Ozaki T, Mori I, Nakamura M, et al (2003). Microwave cell death: immunohistochemical and enzyme histochemical evaluation. Pathol Int, 53, 686-92. https://doi.org/10.1046/j.1440-1827.2003.01537.x
  23. Pacella CM, Bizzarri G, Francica G, et al (2005). Percutaneous laser ablation in the treatment of heaptocellular carcinoma with small tumors: analysis of factors affecting the achievement of tumor necrosis. J Vasc Interv Radiol, 16, 1427-57. https://doi.org/10.1097/01.RVI.0000188755.61481.E8
  24. Pua BB, Solomon SB (2009). Radiofrequency ablation of primary and metastatic lung cancers. Semin Ultrasound CT MR, 30, 113-24. https://doi.org/10.1053/j.sult.2008.12.001
  25. Rasekhi AR, Naderifar M, Bagheri MH, et al (2009). Radiofrequency ablation of the spleen in patients with thalassemia intermedia: a pilot study. Am J Roentgenol, 192, 1425-9. https://doi.org/10.2214/AJR.08.1382
  26. Shock SA, Meredith K, Warner TF, et al (2004). Microwave ablation with loop antenna: in vivo porcine liver model. Radiology, 231, 143-9. https://doi.org/10.1148/radiol.2311021342
  27. Tateishi R, Shiina S, Teratani T, et al (2005). Percutaneous radiofrequency ablation for hepatocellular carcinoma: an analysis of 1000 cases. Cancer, 103, 1201-9. https://doi.org/10.1002/cncr.20892
  28. Wright AS, Lee FT Jr, Mahvi DM (2003). Hepatic microwave ablation with multiple antennae results in synergistically larger zones of coagulation necrosis. Ann Surg Oncol, 10, 275-83. https://doi.org/10.1245/ASO.2003.03.045
  29. Wright AS, Sampson LA, Warner TF, Mahvi DM, Lee Jr (2005). Radiofrequency versus microwave ablation in a hepatic porcine model. Radiology, 236, 132-9. https://doi.org/10.1148/radiol.2361031249
  30. Yang WZ, Jiang N, Huang N, et al (2009). Combined therapy with transcatheter arterial chemoembolization and percutaneous microwave coagulation for small hepatocellular carcinoma. World J Gastroenterol, 14, 748-52.
  31. Yin XY, Xie XY, Lu MD, et al (2009). Percutaneous thermal ablation of medium and large hepatocellular carcinoma. Cancer, 115, 1914-23. https://doi.org/10.1002/cncr.24196

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