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Association Between the Ku70-1310C/G Promoter Polymorphism and Cancer Risk: a Meta-analysis

  • Xu, Lu (Department of Breast Surgery, The First Affiliated Hospital with Nanjing Medical University) ;
  • Ju, Xiao-Bing (Department of Urology, The First Affiliated Hospital with Nanjing Medical University) ;
  • Li, Pu (Department of Urology, The First Affiliated Hospital with Nanjing Medical University) ;
  • Wang, Jue (Department of Breast Surgery, The First Affiliated Hospital with Nanjing Medical University) ;
  • Shi, Zhu-Mei (Department of Neurosurgery, The First Affiliated Hospital with Nanjing Medical University) ;
  • Zheng, Ming-Jie (Department of Breast Surgery, The First Affiliated Hospital with Nanjing Medical University) ;
  • Xue, Dan-Dan (Department of Breast Surgery, The First Affiliated Hospital with Nanjing Medical University) ;
  • Xu, Yan-Jie (Department of Medical Oncology, The First Affiliated Hospital with Nanjing Medical University) ;
  • Yin, Yong-Mei (Department of Medical Oncology, The First Affiliated Hospital with Nanjing Medical University) ;
  • Wang, Shui (Department of Breast Surgery, The First Affiliated Hospital with Nanjing Medical University) ;
  • You, Yong-Ping (Department of Neurosurgery, The First Affiliated Hospital with Nanjing Medical University)
  • Published : 2012.02.29

Abstract

Ku70 plays an important role in DNA double-strand break repair. Studies revealing conflicting results on the role of the Ku70-1310C/G promoter polymorphism on cancer risk led us to perform a meta-analysis to investigate this relationship. Ten case-control studies with 2566 cases and 3058 controls were identified. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of associations. The overall results suggested no association between the Ku70-1310C/G promoter polymorphism and total cancer risk. However, on stratified analysis, significantly increased risks were observed among the Asian population (GG vs. CC: OR=1.50, 95%CI=1.10-2.06; GG vs. CC/CG: OR=1.47, 95%CI=1.07-2.01) and population-based case-control studies (GG vs. CC: OR=1.57, 95%CI=1.12-2.22; CG vs. CC: OR=1.35, 95%CI=1.11-1.64; CG/GG vs. CC: OR=1.37, 95%CI=1.14-1.65). Additionally, variant genotypes were associated with a significantly increased breast cancer risk (GG vs. CC: OR=1.80, 95%CI=1.26-2.56; GG vs. CC/CG: OR=1.40, 95%CI=1.01-1.95).

Keywords

Ku70;polymorphism;cancer;meta-analysis;carcinogenesis

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