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Clinical Significance of Axin and β-catenin Protein Expression in Primary Hepatocellular Carcinomas

  • Guan, Cheng-Nong (Department of Oncology, the Affiliated Hospital of Guangdong Medical College) ;
  • Chen, Xin-Ming (Department of Oncology, the Affiliated Hospital of Guangdong Medical College) ;
  • Lou, Hai-Qing (Department of Oncology, the Affiliated Hospital of Guangdong Medical College) ;
  • Liao, Xiang-Hui (Department of Oncology, the Affiliated Hospital of Guangdong Medical College) ;
  • Chen, Bao-Ying (Department of Oncology, the Affiliated Hospital of Guangdong Medical College) ;
  • Zhang, Pei-Weng (Department of Oncology, the Affiliated Hospital of Guangdong Medical College)
  • Published : 2012.02.29

Abstract

The aim of the present research was to investigate clinicopathologic correlations of immunohistochemically-demonstrated axin (axis inhibition) and ${\beta}$-catenin expression in primary hepatocellular carcinomas (HCCs), in comparison with paraneoplastic, cirrhotic and normal liver tissues. Variation in Axin expression across groups were significant (P < 0.01), correlating with alpha fetoprotein (AFP), HBsAg, cancer plugs in the portal vein, and clinical stage of HCCs(P < 0.05); however, there were no links with sex, age, and tumour size (P > 0.05). Differences in cell membrane ${\beta}$-catenin expression were also statistically significant (P < 0.01), again correlated with AFP, HBsAg, cancer plugs in the portal vein, and clinical stage in HCCs (P < 0.05) but not with sex, age, and tumour size (P > 0.05). Axin expression levels in tissues with reduced membrane ${\beta}$-catenin were low (P < 0.05), also being low with nuclear ${\beta}$-catenin expression (P < 0.05). Axin and ${\beta}$-catenin may play an important role in the genesis and progression of HCC via the Wnt signal transmission pathway. Simultaneous determination of axin, ${\beta}$-catenin, AFP, and HBsAg may be useful for early diagnosis, and metastatic and clinical staging of HCCs.

Keywords

Axin;${\beta}$-catenin;hepatocellular;immunohistochemstry

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