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Genetic Variants in Interleukin-2 and Risk of Lymphoma among Children in Korea

  • Published : 2012.02.29

Abstract

To estimate the genetic susceptibility for childhood lymphoma, we conducted an association study for 23 cases and 148 controls. Total 1536 tag single nucleotide polymorphisms (SNPs) were selected in 138 candidate gene regions related to immune responses, apoptosis, the cell cycle, and DNA repair. Twelve SNPs were significantly associated with the risk of lymphoma ($P_{trend}$ <0.05) in six genes ($IL1RN$, $IL2$, $IL12RB1$, $JAK3$, $TNFRSF13B$, and $XRCC3$). The most significant association was seen for $IL2$ variant rs2069762 ($OR_{TG+GG}$ vs. TT=3.43 (1.29-9.11), $P_{trend}$=0.002, min$P$=0.005). These findings suggest that common genetic variants in $IL2$ might play a role in the pathogenesis of childhood lymphoma.

Keywords

Childhood lymphoma;genetic variation;IL2;Korea

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  3. The Roles of Ca2+/NFAT Signaling Genes in Kawasaki Disease: Single- and Multiple-Risk Genetic Variants vol.4, pp.1, 2015, https://doi.org/10.1038/srep05208
  4. Joint effects of folate intake and one-carbon-metabolizing genetic polymorphisms on breast cancer risk: a case-control study in China vol.6, pp.1, 2016, https://doi.org/10.1038/srep29555

Acknowledgement

Supported by : NRF