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Novel Hydrophilic Taxane Analogues inhibit Growth of Cancer Cells

  • Fauzee, Nilufer Jasmine Selimah (Department of Pathology, Molecular Medicine and Cancer Research Center, Chongqing Medical University) ;
  • Wang, Ya-Lan (Department of Pathology, Molecular Medicine and Cancer Research Center, Chongqing Medical University) ;
  • Dong, Zhi (Department of Pharmacology, Pharmacy College, Chongqing Medical University) ;
  • Li, Qian-Ge (Department of Pharmacology, Pharmacy College, Chongqing Medical University) ;
  • Wang, Tao (Department of Pharmacology, Pharmacy College, Chongqing Medical University) ;
  • Mandarry, Muhammad Tasleem (Department of General Surgery, The First Affiliated Hospital of Chongqing Medical University) ;
  • Lu, Xu (Department of Pharmacology, Pharmacy College, Chongqing Medical University) ;
  • Juan, Pan (Department of Pathology, Molecular Medicine and Cancer Research Center, Chongqing Medical University)
  • Published : 2012.02.29

Abstract

In our era there has been several anti-cancer drugs which have undergone both experimental and clinical trials; however, due to their poor solubilities, numerous side effects, insufficient bioavailability and poor compliance, many have resulted into poor outcomes. Therefore, our aim was to investigate the effects of novel hydrophilic taxanes analogues CQMU-0517 and CQMU-0519 on growth of A549 lung, SKVO3 ovary and MCF7 breast carcinoma cell lines. Different concentrations of original paclitaxel, CQMU-0517, original docetaxel and CQMU-0519 were utilized on three cell lines, where cell growth was assessed using cell culture kit-8 and flow cytometry analysis. The results unveiled that CQMU-0517 and CQMU-0519 suppressed cell growth in the three particular cell lines, cell cycle arrest being evident in the G2/M phase. Hence, the results showed that these new taxane analogues have potential and warrant future clinical trials.

Keywords

Taxol;paclitaxel;taxotere;docetaxel;growth

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