- Volume 13 Issue 12
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Clinical and Biochemical Profile of Monoclonal Gammopathies in Caribbean Patients in a Resource-limited Setting
- Buchner-Daley, Loretta (Department of Pathology, Faculty of Medical Sciences, University of the West Indies) ;
- Brady-West, Doreen (Department of Pathology, Faculty of Medical Sciences, University of the West Indies) ;
- McGrowder, Donovan (Department of Pathology, Faculty of Medical Sciences, University of the West Indies)
- Published : 2012.12.31
Background: Multiple myeloma is the most common malignant plasma cell dyscrasia and ranks second among primary haematological malignancies. This study describes the epidemiologic, clinical and pathologic profile of monoclonal gammopathies seen in the University Hospital of the West Indies (UHWI), a tertiary care referral centre. Materials and Method: A retrospective analysis of 85 cases diagnosed at UHWI over the 5-year period 2003-2007 was conducted. The cases were identified from the bone marrow records as well as the computerized database of the Medical Records Department. Clinical presentation, family and personal history and demographic data were retrieved. Haematological and biochemical results were also analyzed. Results: There were 85 patients diagnosed with monoclonal gammopathies. The M:F ratio was 1.2:1 and the mean age was
Monoclonal gammopathy;multiple myeloma;clinical and biochemical abnormalities
- Anderson KC, Alsina A, Bensinger W, et al (2011). Multiple Myeloma. J Natl Compr Canc Netw, 9, 1146-83.
- Dispenzieri A, Kyle RA, Katzmann JA, et al (2008). Immunoglobulin free light chain ratio is an independent risk factor for progression of smoldering (asymptomatic) multiple myeloma. Blood, 111, 785-9. https://doi.org/10.1182/blood-2007-08-108357
- Drayson M, Tang LX, Drew R, et al (2001). Serum free light chain measurements for identifying and monitoring patients with non-secretory multiple myeloma. Blood, 97, 2900-2. https://doi.org/10.1182/blood.V97.9.2900
- Durie BG, Salmon SE (1975). A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment and survival. Cancer, 36, 842-54. https://doi.org/10.1002/1097-0142(197509)36:3<842::AID-CNCR2820360303>3.0.CO;2-U
- International Myeloma Working Group (2003). Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group. Br J Haematol, 121, 749-57. https://doi.org/10.1046/j.1365-2141.2003.04355.x
- Kyle RA, Gertz MA, Witzig TE (2003). Review of 1027 patients with newly diagnosed multiple myeloma. Mayo Clin Proc, 78, 21-33. https://doi.org/10.4065/78.1.21
- Kyle RA, Rajkumar SV (2004). Multiple myeloma. N Engl J Med, 351, 1860-73. https://doi.org/10.1056/NEJMra041875
- Nau KC, Lewis WD (2008). Multiple myeloma: diagnosis and treatment. Am Fam Physician, 78, 853-9.
- Nowrousian MR, Brandhorst D, Sammet C, et al (2005). Serum free light chain analysis and urine immunofixation electrophoresis in patients with multiple myeloma. Clin Cancer Res, 15, 8706-14.
- Oyajobi BO, Mundy GR (2004). Pathophysiology of myeloma bone disease. In: Gahrton G, Durie BGM, Samson DS, editor. Multiple Myeloma and Related Disorders. 2. London, UK: Arnold; pp. 74-88
- Podczaski E, Cain J (2002). Multiple Myeloma. Clinical Obstetrics and Gynecology, 45, 928-38. https://doi.org/10.1097/00003081-200209000-00038
- Rajkumar SV, Kyle RA (2007). Plasma cell disorders. In: Goldman L, Ausiello D, eds. Cecil Textbook of Medicine, 23rd ed. Philadelphia, PA: Saunders; 1426-37.
- Roodman DG (2001). Biology of Osteoclast Activation in Cancer. J Clinical Oncology, 19, 3562-71.
- Sawyer JR (2011). The prognostic significance of cytogenetics and molecular profiling in multiple myeloma. Cancer Genetics, 204, 3-12. https://doi.org/10.1016/j.cancergencyto.2010.11.002
- Umeda M, Adachi Y, Tomiyama J, et al (2002). Bone lesions in elderly multiple myeloma. Nihon Ronen Igakkai Zasshi, 39, 631-8. https://doi.org/10.3143/geriatrics.39.631
- van Rhee F, Bolejack V, Hollmig K, et al (2007). High serum free-light chain levels and their rapid reduction in response to therapy define an aggressive multiple myeloma subtype with poor prognosis. Blood, 110, 827-32 https://doi.org/10.1182/blood-2007-01-067728
- Verma PS, Howard RS, Weiss BM (2008). The impact of race on outcomes of autologous transplantation in patients with multiple myeloma. Am J Hematol, 83, 355-8. https://doi.org/10.1002/ajh.21139
- Weiss BM, Minter A, Abadie J, et al (2011). Patterns of monoclonal immunoglobulins and serum free light chains are significantly different in black compared to white monoclonal gammopathy of undetermined significance (MGUS) patients. Am J Hematol, 86, 475-8. https://doi.org/10.1002/ajh.22025
- Zhou Y, Barlogie B, Shaughnessy JD Jr (2009). The molecular characterization and clinical management of multiple myeloma in the post-genome era. Leukemia, 23, 1941-56. https://doi.org/10.1038/leu.2009.160
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