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DNA Repair Gene Polymorphisms at XRCC1, XRCC3, XPD, and OGG1 Loci in the Hyderabad Population of India

  • Parine, Narasimha Reddy (Genome Research Chair, Department of Biochemistry, College of Science, King Saud University) ;
  • Pathan, Akbar Ali Khan (Genome Research Chair, Department of Biochemistry, College of Science, King Saud University) ;
  • Bobbarala, Varaprasad (Krisani Biosciences Limited.) ;
  • Abduljaleel, Zainularifeen (Genome Research Chair, Department of Biochemistry, College of Science, King Saud University) ;
  • Khan, Wajahatullah (Genome Research Chair, Department of Biochemistry, College of Science, King Saud University) ;
  • Alanazi, Mohammed (Genome Research Chair, Department of Biochemistry, College of Science, King Saud University)
  • Published : 2012.12.31

Abstract

Background: DNA repair is one of the crucial defense mechanism against mutagenic exposure. Inherited SNPs of DNA repair genes may contribute to variation in DNA repair capacity and susceptibility to cancer. Due to the presence of these variants, inter-individual and ethnic differences in DNA repair capacity have been established in various populations. India harbors enormous genetic and cultural diversity. Materials and Methods: In the present study we aimed to determine the genotypes and allele frequencies of XRCC1 Arg399Gln (rs25487), XRCC3 Thr241Met (rs861539), XPD Lys751Gln (rs13181), and OGG1 Ser326Cys (rs1052133) gene polymorphisms in 186 healthy individuals residing in the Hyderabad region of India and to compare them with HapMap and other populations. Results and Conclusions: The genotype and allele frequency distribution at the four DNA repair gene loci among Hyderabad population of India revealed a characteristic pattern. Comparison of these gene polymorphisms with other populations revealed a distinctiveness of Hyderabad population from the Deccan region of India. To the best of our knowledge, this is the first report of such DNA repair gene polymorphisms in the Deccan Indian population.

Keywords

DNA repair;genotyping;XRCC3;XRCC1;XPD;OGG1;Deccan, India

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