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XRCC1 Polymorphisms are Associated with Cervical Cancer Risk and Response to Chemotherapy: a Systematic Review and Meta-analysis

  • Shuai, Han-Lin (Department of Obstetrics and Gynecology, the First Affiliated Hospital of Jinan University) ;
  • Luo, Xin (Department of Obstetrics and Gynecology, the First Affiliated Hospital of Jinan University) ;
  • Yan, Rui-Ling (Department of Obstetrics and Gynecology, the First Affiliated Hospital of Jinan University) ;
  • Li, Jian (Department of Obstetrics and Gynecology, the First Affiliated Hospital of Jinan University) ;
  • Chen, Dan-Liang (Department of Obstetrics and Gynecology, the First Affiliated Hospital of Jinan University)
  • Published : 2012.12.31

Abstract

Background: Functional single nucleotide polymorphisms of x-ray repair cross-complementing protein 1 (XRCC1) have been suspected to contribute to uterine cervical cancer risk for a long time; however, most previous case-control studies were small sized and biased. Additionally, recent studies suggested that XRCC1 polymorphisms could be a biomarker of response to platinum-based chemotherapy. Methods: A comprehensive search was conducted to retrieve eligible studies and odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated to measure association strength. Results: A total of 13 studies were identified and analyzed. We found that the Arg194Trp polymorphism (Trp vs. Arg, OR=1.342, 95% CI: 1.176) was associated with increased risk of cervical cancer, while no significant association was found with Arg280His (His vs. Arg, OR=1.059, 95% CI: 0.863, 1.299) or Arg399Gln (Gln vs. Arg, OR=1.144, 95% CI: 0.938, 1.394). As for response to platinum-based chemotherapy, the variant XRCC1 399Gln allele (Gln vs. Arg, OR=0.345, 95% CI: 0.163, 0.729) was linked with a poor response; however, the Arg194Trp polymorphism (TrpArg vs. ArgArg, OR=6.421, 95% CI: 1.573, 26.205) predicted a good response. Conclusion: The Arg194Trp polymorphism of XRCC1 increases risk of cervical cancer; the variant 399Gln allele predicts poor response to platinum-based chemotherapy, while the Arg194Trp polymorphism indicates a good response.

Keywords

XRCC1;uterine cervical cancer;SNPs;susceptibility;chemotherapy response

Acknowledgement

Supported by : Guangdong Medical Science and Technology Research

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