- Volume 13 Issue 12
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Human Epididymis Protein 4 Reference Intervals in a Multiethnic Asian Women Population
- Mokhtar, N.M. (Department of Pathology, Faculty of Medicine, University Malaya) ;
- Thevarajah, M. (Department of Pathology, Faculty of Medicine, University Malaya) ;
- M.A., Noorazmi (Department of Obstetrics and Gynecology, Faculty of Medicine, University Malaya) ;
- M., Isahak (Centre for Occupational and Environmental Health, Faculty of Medicine, University Malaya)
- Published : 2012.12.31
Background: Ovarian cancer is ranked as the fifth most common cause of cancer death in women. In Malaysia, it is the fourth most common cancer in females. CA125 has been the tumor marker of choice in ovarian cancer but its diagnostic specificity in early stages is only 50%. Hence, there is a critical need to identify an alternative tumor marker that is capable of detecting detect ovarian cancer at an early stage. HE4 is a new tumor marker proposed for the early diagnosis of ovarian cancer and disease recurrence. Currently, none of the normal ranges of HE4 quoted in the literature are based on data for a multiethnic Asian population. Therefore, the aim of this study was to determine reference intervals for HE4 in an Asian population presenting in University Malaya Medical Centre, a tertiary reference hospital. Materials and Methods: 300 healthy women were recruited comprising 150 premenopausal and 150 postmenopausal women, aged from 20-76 years. All women were subjected to a pelvic ultrasonograph and were confirmed to be free from ovarian pathology on recruitment. Serum HE4 levels were determined by chemiluminescent microparticle immunoassay (CMIA, Abbott Architect). The reference intervals were determined following CLSI guidelines (C28-A2) using a non-parametric method. Results: The upper limits of the
Ovarian cancer;biomarker;HE4;Asian women;ethnic groups
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